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Research ArticleHEAD AND NECK

Warthin Tumor of the Parotid Gland: Diagnostic Value of MR Imaging with Histopathologic Correlation

Mitsuaki Ikeda, Ken Motoori, Toyoyuki Hanazawa, Yuichiro Nagai, Seiji Yamamoto, Takuya Ueda, Hiroyuki Funatsu and Hisao Ito
American Journal of Neuroradiology August 2004, 25 (7) 1256-1262;
Mitsuaki Ikeda
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Ken Motoori
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Toyoyuki Hanazawa
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Yuichiro Nagai
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Seiji Yamamoto
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Takuya Ueda
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Hiroyuki Funatsu
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Hisao Ito
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    Fig 1.

    Images of a Warthin tumor in the left parotid gland of a 70-year-old man.

    A, STIR image (4000/30), obtained in the axial plane, shows the tumor with moderate-to-high signal intensity. The high-signal-intensity area is a cystic lesion (*); the area showed no enhancement on contrast-enhanced images (see panel C, region of interest 2).

    B, T1-weighted image (400/9), obtained in the axial plane, shows a hypointense tumor.

    C, Fat suppression contrast-enhanced T1-weighted image (300/20), obtained in the coronal plane, shows solid (region of interest 1) and cystic (region of interest 2) tumor in the inferior pole of the parotid gland.

    D, Signal intensity graph shows that the washout ratio of the solid component was 41%. The cystic region shows no enhancement (type E). The ADC values of the solid and cystic components were 0.96 × 10−3 mm2/s and 2.74 × 10−3 mm2/s, respectively. The ADC value of the spinal cord was 1.02 × 10−3 mm2/s.

    E, Axial section of the specimen shows solid and large cystic components (*). The large cyst lost its contents.

    F, Solid component has slitlike or dendriform spaces (*) lined with papillary proliferation of bilayered oncocytic epithelia, with supporting stroma composed largely of lymphoid tissue (**). The small slitlike cysts are filled with proteinous secretion.

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    Fig 2.

    Images of a Warthin tumor in the left parotid gland of a 61-year-old man.

    A, STIR image (4000/30), obtained in the axial plane, shows the tumor to be iso- to hypointense to the parotid gland. Characteristically small low-signal-intensity foci (arrows) can be detected. The margin of the tumor also has hypointense foci.

    B, T1-weighted image (400/9), obtained in the axial plane, shows the tumor to have the isointensity of muscle and relatively high-signal-intensity areas, whereas the STIR image shows low-signal-intensity areas (arrows). The margin of the tumor also is hypointense on T1-weighted images.

    C, Axial dynamic contrast-enhanced image shows all areas of this tumor to have type B perfusion curves.

    D, Signal intensity graph shows that foci that showed hypointensity on the STIR image and relatively high signal intensity on the T1-weighted image (region of interest 1) had a low washout ratio (3%) and the other region (region of interest 2) had a high washout ratio (54%).

    E, Axial section of the specimen shows cysts containing proteinous fluid with inflammatory cells (*).

Tables

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    TABLE 1:

    Histopathology diagnoses of salivary gland tumors

    DiagnosisNo. of Lesions
    Benign (n = 19)
     Warthin tumor19
    Malignant (n = 17)
     Mucoepidermoid carcinoma1
     Acinic cell adenocarcinoma4
     Adenoid cystic carcinoma2
     Salivary duct carcinoma5
     Squamous cell carcinoma1
     Basal cell adenocarcinoma1
     Carcinoma ex pleomorphic adenoma3
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    TABLE 2:

    Time intensity curves of tumors as shown by dynamic MR imaging

    Case No.Curve Types
    ABC1C2C3C4DE
    WA 1+ (41–50)+
    WA 2+ (39–50)+
    WA 3+ (22–38)
    WA 4+ (50–58)+
    WA 5+ (3–54)
    WA 6+ (45)
    WA 7+ (39)
    WA 8+ (40–52)
    WA 9+ (97)
    WA10+ (45)
    WA11+ (52)
    WA12+ (22–32)
    WA13+ (50)+ (29)
    WA14+ (22–47)+
    WA15+ (18)+
    WA16+ (73–102)
    WA17+ (45)+ (0)+
    WA18+ (46–61)
    WA19+ (11–55)
    AC 1+ (22)
    AC 2+ (25)
    AC 3+ (20)+
    AC 4+ (18–24)+ (4.4)
    ME 1+ (38)+ (11)
    ACC1+ (15)+ (0)
    ACC2+ (17)+ (0)+
    SD 1+ (11)+ (6)+
    SD 2+ (0)
    SD 3+ (12)+
    SD 4+ (0)
    SD 5+ (16–27)+ (0)
    SQ 1+ (18–35)
    BC 1+ (16)+ (5)+ (0)
    CEP1+ (0)
    CEP2+ (6)+ (0)+
    CEP3+ (25)+ (4)+
    • Note.—WA indicates Warthin tumor; AC, acinic cell adenocarcinoma; ME, mucoepidermoid carcinoma; ACC, adenoid cystic carcinoma; SD, salivary duct carcinoma; SQ, squamous cell carcinoma; BC, basal cell adenocarcinoma; CEP, carcinoma ex pleomorphic adenoma. Washout ratio, shown in parentheses, is expressed as a percentage.

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American Journal of Neuroradiology: 25 (7)
American Journal of Neuroradiology
Vol. 25, Issue 7
1 Aug 2004
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Mitsuaki Ikeda, Ken Motoori, Toyoyuki Hanazawa, Yuichiro Nagai, Seiji Yamamoto, Takuya Ueda, Hiroyuki Funatsu, Hisao Ito
Warthin Tumor of the Parotid Gland: Diagnostic Value of MR Imaging with Histopathologic Correlation
American Journal of Neuroradiology Aug 2004, 25 (7) 1256-1262;

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Warthin Tumor of the Parotid Gland: Diagnostic Value of MR Imaging with Histopathologic Correlation
Mitsuaki Ikeda, Ken Motoori, Toyoyuki Hanazawa, Yuichiro Nagai, Seiji Yamamoto, Takuya Ueda, Hiroyuki Funatsu, Hisao Ito
American Journal of Neuroradiology Aug 2004, 25 (7) 1256-1262;
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Cited By...

  • Diffusion weighted magnetic resonance imaging in the diagnosis of parotid masses. Preliminary results
  • Evaluating Instantaneous Perfusion Responses of Parotid Glands to Gustatory Stimulation Using High-Temporal-Resolution Echo-Planar Diffusion-Weighted Imaging
  • CT and Ultrasound Features of Basal Cell Adenoma of the Parotid Gland: A Report of 22 Cases with Pathologic Correlation
  • Diagnosing common parotid tumours with magnetic resonance imaging including diffusion-weighted imaging vs fine-needle aspiration cytology: a comparative study
  • Diffusion-Weighted Echo-Planar MR Imaging of Primary Parotid Gland Tumors: Is a Prediction of Different Histologic Subtypes Possible?
  • Current controversies in the management of Warthin tumour
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