Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleSPINE

Apparent Diffusion Coefficients in Spinal Cord Transplants and Surrounding White Matter Correlate with Degree of Axonal Dieback After Injury in Rats

Eric D. Schwartz, Chih-Liang Chin, Jed S. Shumsky, Abbas F. Jawad, B. Kooper Brown, Suzanne Wehrli, Alan Tessler, Marion Murray and David B. Hackney
American Journal of Neuroradiology January 2005, 26 (1) 7-18;
Eric D. Schwartz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chih-Liang Chin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jed S. Shumsky
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abbas F. Jawad
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Kooper Brown
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Suzanne Wehrli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Tessler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marion Murray
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David B. Hackney
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Selzer ME. Promotion of axonal regeneration in the injured CNS. Lancet Neurol 2003;2:157–166
    CrossRefPubMedWeb of Science
  2. ↵
    Raineteau O, Schwab ME. Plasticity of motor systems after incomplete spinal cord injury. Nat Rev Neurosci 2001;2:263–273
    CrossRefPubMedWeb of Science
  3. ↵
    Ford JC, Hackney DB, Alsop DC, et al. MRI characterization of diffusion coefficients in a rat spinal cord injury model. Magn Reson Med 1994;31:488–494
    PubMedWeb of Science
  4. ↵
    Schwartz ED, Shumsky JS, Wehrli S, Tessler A, Murray M, Hackney DB. Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF. Exp Neurol 2003;182:49–63
    CrossRefPubMed
  5. ↵
    Nevo U, Hauben E, Yoles E, et al. Diffusion anisotropy MRI for quantitative assessment of recovery in injured rat spinal cord. Magn Reson Med 2001;45:1–9
    CrossRefPubMedWeb of Science
  6. ↵
    Kim D, Liu Y, Browarek T, et al. Transplants of fibroblasts genetically modified to express BDNF promote recovery of forelimb and hindlimb funtions in the adult rat [abstr]. Abstr Soc Neurosci 1999;25:492
  7. Kim D, Schallert T, Liu Y, et al. Transplantation of genetically modified fibroblasts expressing BDNF in adult rats with a subtotal hemisection improves specific motor and sensory functions. Neurorehabil Neural Repair 2001;15:141–150
    Abstract/FREE Full Text
  8. ↵
    Liu Y, Kim D, Himes BT, et al. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function. J Neurosci 1999;19:4370–4387
    Abstract/FREE Full Text
  9. Himes BT, Tessler A. Neuroprotection from cell death following axotomy. In: Ingoglia NA, Murray M, eds. Axonal Regeneration in the Central Nervous System. New York: Marcel Dekker,2001;477–503
  10. ↵
    Jin Y, Fischer I, Tessler A, Houle JD. Transplants of fibroblasts genetically modified to express BDNF promote axonal regeneration from supraspinal neurons following chronic spinal cord injury. Exp Neurol 2002;177:265–275
    CrossRefPubMedWeb of Science
  11. ↵
    Liu Y, Himes BT, Tryon B, et al. Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. Neuroreport 1998;9:1075–1079
    CrossRefPubMedWeb of Science
  12. ↵
    Molander C, Gunnar G. Spinal cord cytoarchitecture. In: Paxinos G, ed. The Rat Nervous System. San Diego: Academic Press, Inc.,1995;39–45
  13. ↵
    Tracey DJ. Ascending and descending pathways in the spinal cord. In: Paxinos G, ed. The Rat Nervous System. San Diego: Academic Press, Inc.,1995 :67–80
  14. ↵
    Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1–21
    CrossRefPubMedWeb of Science
  15. ↵
    Stejskal EO, Tanner JE. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288–292
    CrossRef
  16. ↵
    Mills R. Self-diffusion in normal and heavy water in the range 1–45 degrees. J Phys Chem 1973;77:685–688
    CrossRef
  17. ↵
    Basso DM, Beattie MS, Bresnahan JC. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 1996;139:244–256
    CrossRefPubMedWeb of Science
  18. Merkler D, Metz GA, Raineteau O, Dietz V, Schwab ME, Fouad K. Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A. J Neurosci 2001;21:3665–3673
    Abstract/FREE Full Text
  19. ↵
    Schucht P, Raineteau O, Schwab ME, Fouad K. Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp Neurol 2002;176:143–153
    CrossRefPubMedWeb of Science
  20. ↵
    Croul DE, Flanders AE. Neuropathology of human spinal cord injury. In: Seil FJ, ed. Advances in Neurology, Vol 72; Neuronal Regeneration, Reorganization, and Repair. Philadelphia: Lippincott-Raven,1997
  21. ↵
    DeVivo MJ. Epidemiology of traumatic spinal cord injury. In: Kirshblum S, Campagnolo DI, Delisa JA, eds. Spinal Cord Medicine. Philadelphia: Lippincott Williams and Wilkins,2002 :69–81
  22. ↵
    Bracken MB, Shepard MJ, Collins WFJ, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second national acute spinal cord injury study. J Neurosurg 1992;76:23–31
    CrossRefPubMedWeb of Science
  23. ↵
    Schwab ME. Bridging the gap in spinal cord regeneration. Nat Med 1996;2:976–977
    PubMed
  24. ↵
    Bracken MB. Methylprednisolone and acute spinal cord injury: an update of the randomized evidence [Suppl]. Spine 2001;26:S47–54
    CrossRefPubMedWeb of Science
  25. ↵
    Hurlbert RJ. The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine 2001;26:S39–46
    CrossRefPubMedWeb of Science
  26. ↵
    Murray M. Therapies to promote CNS repair. In: Ingoglia NA, Murray M, eds. Axonal Regeneration in the Central Nervous System. New York: Marcel Dekker, Inc.,2001
  27. ↵
    Lu K, Waite P. Spine update: advances in spinal cord regeneration. Spine 1999;24:926–930
    PubMed
  28. ↵
    Thompson FJ, Reier PJ, Uthman B, et al. Neurophysiological assessment of the feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:931–945
    CrossRefPubMed
  29. ↵
    Wirth ED 3rd, Reier PJ, Fessler RG, et al. Feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:911–929
    CrossRefPubMedWeb of Science
  30. ↵
    McDonald JW, Becker D. Spinal cord injury: promising interventions and realistic goals. Am J Phys Med Rehabil 2003;82:S38–49
    CrossRefPubMedWeb of Science
  31. ↵
    Ramon S, Dominguez R, Ramirez L, et al. Clinical and magnetic resonance imaging correlation in acute spinal cord injury. Spinal Cord 1997;35:664–673
    CrossRefPubMed
  32. Takhtani D, Melhem ER. MR imaging in cervical spine trauma. Magn Reson Imaging Clin N Am 2000;8:615–634
    PubMed
  33. Ditunno JF, Flanders AE, Kirshblum S, Graziani V, Tessler A. Predicing outcome in traumatic spinal cord injury. In: Kirshblum S, Campagnolo DI, Delisa JA, eds. Spinal Cord Medicine. Philadelphia, PA: Lippincott Williams & Wilkins,2002;108–122
  34. Flanders AE, Spettell CM, Friedman DP, Marino RJ, Herbison GJ. The relationship between the functional abilities of patients with cervical spinal cord injury and the severity of damage revealed by MR imaging. Am J Neuroradiol 1999;20:926–934
    Abstract/FREE Full Text
  35. ↵
    Kulkarni MV, McArdle CB, Kopanicky D, et al. Acute spinal cord injury: MR imaging at 1.5 T. Radiology 1987;164:837–843
    PubMedWeb of Science
  36. ↵
    Milhorat TH, Johnson RW, Milhorat RH, Capocelli AL, Pevsner PH. Clinicopathologic correlations in syringomyelia using axial magnetic resonance imaging. Neurosurgery 1995;37:206–213
    PubMed
  37. Jinkins JR, Reddy S, Leite CC, Bazan C, Xiong L. MR of parenchymal spinal cord signal change as a sign of active advancement in clinically progressive posttraumatic syringomyelia. AJNR Am J Neuroradiol 1998;19:177–182
    Abstract
  38. Quencer RM, Sheldon JJ, Post MJ, et al. MRI of the chronically injured cervical spinal cord. AJR Am J Roentgenol 1986;147:125–132
    PubMed
  39. Schurch B, Wichmann W, Rossier AB. Post-traumatic syringomyelia (cystic myelopathy): a prospective study of 449 patients with spinal cord injury. J Neurol Neurosurg Psychiatry 1996;60:61–67
    Abstract/FREE Full Text
  40. Schwartz ED, Falcone SF, Quencer RM, Green BA. Posttraumatic syringomyelia: pathogenesis, imaging, and treatment. AJR Am J Roentgenol 1999;173:487–492
    PubMed
  41. ↵
    Bodley R. Imaging in chronic spinal cord injury: indications and benefits. Eur J Radiol 2002;42:135–153
    PubMed
  42. ↵
    Falci S, Holtz A, Akesson E, et al. Obliteration of a postraumatic spinal cord cyst with solid human embryonic spinal cord grafts: first clinical attempt. J Neurotrauma 1997;14:875–884
    PubMedWeb of Science
  43. ↵
    Schwartz ED, Yezierski RP, Pattany PM, Quencer RM, Weaver RG. Diffusion-weighted MR imaging in a rat model of syringomyelia after excitotoxic spinal cord injury. AJNR Am J Neuroradiol 1999;20:1422–1428
    Abstract/FREE Full Text
  44. ↵
    Schwartz ED, Hackney DB. Diffusion weighted MRI and the evaluation of spinal cord axonal integrity following injury and treatment. Exp Neurol 2003;184:570–589
    CrossRefPubMedWeb of Science
  45. Schwartz ED, Chin CL, Takahashi M, Hwang SN, Hackney DB. Diffusion-weighted imaging of the spinal cord. Neuroimaging Clin N Am 2002;12:125–146
    PubMed
  46. Clark CA, Werring DJ. Diffusion tensor imaging in spinal cord: methods and applications—a review. NMR Biomed 2002;15:578–586
    CrossRefPubMed
  47. ↵
    Beaulieu C. The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed 2002;15:435–455
    CrossRefPubMedWeb of Science
  48. ↵
    Arfanakis K, Haughton VM, Carew JD, Rogers BP, Dempsey RJ, Meyerand ME. Diffusion tensor MR imaging in diffuse axonal injury. AJNR Am J Neuroradiol 2002;23:794–802
    Abstract/FREE Full Text
  49. ↵
    Sotak CH. The role of diffusion tensor imaging in the evaluation of ischemic brain injury: a review. NMR Biomed 2002;15:561–569
    CrossRefPubMedWeb of Science
  50. ↵
    Takahashi M, Fritz-Zieroth B, Chikugo T, Ogawa H. Differentiation of chronic lesions after stroke in stroke-prone spontaneously hypertensive rats using diffusion weighted MRI. Magn Reson Med 1993;30:485–488
    PubMedWeb of Science
  51. ↵
    Vorisek I, Hajek M, Tintera J, Nicolay K, Sykova E. Water ADC, extracellular space volume, and tortuosity in the rat cortex after traumatic injury. Magn Reson Med 2002;48:994–1003
    CrossRefPubMedWeb of Science
  52. ↵
    Hauben E, Butovsky O, Nevo U, et al. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J Neurosci 2000;20:6421–6430
    Abstract/FREE Full Text
  53. ↵
    Oudega M, Vargas CG, Weber AB, Kleitman N, Bunge MB. Long-term effects of methylprednisolone following transection of adult rat spinal cord. Eur J Neurosci 1999;11:2453–2464
    CrossRefPubMedWeb of Science
  54. ↵
    Pallini R, Fernandez E, Sbriccoli A. Retrograde degeneration of corticospinal axons following transection of the spinal cord in rats. J Neurosurg 1988;68:124–128
    PubMedWeb of Science
  55. ↵
    Hill CE, Beattie MS, Bresnahan JC. Degeneration and sprouting of identified descending supraspinal axons after contusive spinal cord injury in the rat. Exp Neurol 2001;171:153–169
    CrossRefPubMedWeb of Science
  56. ↵
    Houle JD, Jin Y. Chronically injured supraspinal neurons exhibit only modest axonal dieback in response to a cervical hemisection lesion. Exp Neurol 2001;169:208–217
    CrossRefPubMedWeb of Science
  57. ↵
    Sun SW, Neil JJ, Song SK. Relative indices of water diffusion anisotropy are equivalent in live and formalin-fixed mouse brains. Magn Reson Med 2003;50:743–748
    CrossRefPubMedWeb of Science
  58. ↵
    Gulani V, Iwamoto GA, Jiang H, Shimony JS, Webb AG, Lauterbur PC. A multiple echo pulse sequence for diffusion tensor imaging and its application in excised rat spinal cords. Magn Reson Med 1997;38:868–873
    CrossRefPubMed
  59. ↵
    Fan Y, Bertrand L, Hackney DB, Schwartz ED, Nissanov J. An automated active contour method for segmentation of white matter histologic images [abstr]. Presented at the 41st annual meeting of the American Society of Neuroradiology, Washington, DC, April 27–May 2,2003
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 26 (1)
American Journal of Neuroradiology
Vol. 26, Issue 1
1 Jan 2005
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Apparent Diffusion Coefficients in Spinal Cord Transplants and Surrounding White Matter Correlate with Degree of Axonal Dieback After Injury in Rats
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Eric D. Schwartz, Chih-Liang Chin, Jed S. Shumsky, Abbas F. Jawad, B. Kooper Brown, Suzanne Wehrli, Alan Tessler, Marion Murray, David B. Hackney
Apparent Diffusion Coefficients in Spinal Cord Transplants and Surrounding White Matter Correlate with Degree of Axonal Dieback After Injury in Rats
American Journal of Neuroradiology Jan 2005, 26 (1) 7-18;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Apparent Diffusion Coefficients in Spinal Cord Transplants and Surrounding White Matter Correlate with Degree of Axonal Dieback After Injury in Rats
Eric D. Schwartz, Chih-Liang Chin, Jed S. Shumsky, Abbas F. Jawad, B. Kooper Brown, Suzanne Wehrli, Alan Tessler, Marion Murray, David B. Hackney
American Journal of Neuroradiology Jan 2005, 26 (1) 7-18;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Methodological Considerations
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Growing Minds, Integrating Senses: Neural and Computational Insights into Age-related Changes in Audio-Visual and Tactile-Visual Learning in Children
  • Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Bern Score Validity for SIH
  • MP2RAGE 7T in MS Lesions of the Cervical Spine
  • Deep Learning for STIR Spine MRI Quality
Show more Spine

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire