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Research ArticleHead and Neck Imaging

Evaluation of the Upper Airway Cross-sectional Area Changes in Different Degrees of Severity of Obstructive Sleep Apnea Syndrome: Cephalometric and Dynamic CT Study

Aylin Yucel, Mehmet Unlu, Alpay Haktanir, Murat Acar and Fatma Fidan
American Journal of Neuroradiology November 2005, 26 (10) 2624-2629;
Aylin Yucel
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Mehmet Unlu
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Alpay Haktanir
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Murat Acar
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Fatma Fidan
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    Fig 1.

    A, Cross-sectional image of a patient at the level of uvula in tidal breathing. B, The significant narrowing at the same level in forced expiration is seen. The region of interest (white line) was used to assess total cross-sectional areas in each image.

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    Fig 2.

    Lateral scout view showing skeletal and soft tissue profile landmarks and the levels at which CT sections were obtained. S, sella; N, nasion; A, subspinale; B, supramental; H, hyoid; MP, mandibular plane; U, tip of the uvula; PNS, posterior nasal spine; SP-max, maximum thickness of the soft palate; level 1, level of tip of the uvula; level 2, level of hypopharynx.

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    Fig 3.

    Mean cross-sectional areas at the level of uvula in tidal breathing, at the end of both forced inspiration and expiration in each group.

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    Fig 4.

    Mean cross-sectional areas at the level of hypopharynx in tidal breathing, at the end of both forced inspiration and expiration in each group.

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    TABLE 1:

    Parameters of patients according to stages of OSAS and control group

    ParametersControl Group (n = 24) (mean ± SD)Mild/Moderate OSAS (n = 27) (mean ± SD)Severe OSAS (n = 20) (mean ± SD)P* Value
    Age (y)46.0 ± 14.349.0 ± 6.049.0 ± 10.0.533
    BMI (kg/m2)34.1 ± 7.033.9 ± 5.731.7 ± 5.1.357
    Neck circumference (cm)37.4 ± 4.438.3 ± 4.240.6 ± 3.8.043
    AHI2.1 ± 1.413.9 ± 6.750.8 ± 15.6.000
    Uvula tidal breathing area (mm2)233.2 ± 89.9224.7 ± 68.6202.8 ± 76.7.418
    Uvula inspiration area (mm2)215.2 ± 94.3247.4 ± 107.6205.7 ± 146.7.425
    Uvula expiration area (mm2)205.6 ± 106.3219.6 ± 82.7137.2 ± 73.6.007
    Hypopharynx tidal breathing area (mm2)349.2 ± 117.8257.1 ± 88.7366.2 ± 137.2.453
    Hypopharynx inspiration area (mm2)333.8 ± 118.4338.6 ± 131.8345.6 ± 146.8.698
    Hypopharynx expiration area (mm2)272.8 ± 107.5323.6 ± 150.0307.0 ± 140.2.344
    MP-H (mm)15.0 ± 5.715.2 ± 6.420.0 ± 8.1.029
    PNS-U (mm)35.0 ± 3.634.9 ± 4.137.5 ± 6.1.120
    SP-max (mm)10.0 ± 2.09.6 ± 2.211.6 ± 2.2.009
    SNA (angle)81.5 ± 4.981.3 ± 6.284.0 ± 5.0.211
    SNB (angle)79.3 ± 4.079.1 ± 5.181.1 ± 5.3.347
    ANB (angle)2.1 ± 3.61.9 ± 3.42.9 ± 3.4.628
    • Note.—OSAS indicates obstructive sleep apnea syndrome; AHI, apnea-hypopnea index; MP-H, distance from mandibulas plane to the hyoid bone; PNS-U, distance from the posterior nasal spine to the tip of the uvula; SP-max, maximum distance of the soft palate perpendicular to PNS-U; SNA, SNB, ANB, angles where S is the midpoint of the sella, N is the nasion, A is the deepest point on the premaxillary outer contour, and B is the deepest point on the outer mandibular contour.

    • * Compared by using the one-way ANOVA. Significant values are shown in boldface.

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    TABLE 2:

    Significant correlations among AHI, neck circumference, cephalometric parameters, and upper airway size in patients with OSAS

    ParametersNC (cm)PNS-U (mm)SP-max (mm)MP-H (mm)EUNHIH
    AHI.411.363.339.420−.446.376
    NC1000.383
    PNS-U.3831000.422.545
    SP-max.4221000−.365
    MP-H.5451000.306
    SNB (angle).380
    IU.325
    • Note.—Values are correlation coefficients. Significance is defined as P < .05. AHI indicates apnea-hypopnea index; OSAS, obstructive sleep apnea syndrome; NC, neck circumference; PNS-U, distance from the posterior nasal spine to the tip of the uvula; SP-max, maximum distance of the soft palate perpendicular to PNS-U; MP-H, distance from mandibular plane to the hyoid bone; EU, cross-sectional area at level of uvula in expiration; NH, cross-sectional area at level of hypopharynx in tidal breathing; IH, cross-sectional area at level of hypopharynx in inspiration; SNB, angle where S is the midpoint of the sella, N is the nasion, and B is the deepest point on the outer mandibular contour; IU, cross-sectional area at level of uvula in inspiration.

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American Journal of Neuroradiology: 26 (10)
American Journal of Neuroradiology
Vol. 26, Issue 10
1 Nov 2005
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Aylin Yucel, Mehmet Unlu, Alpay Haktanir, Murat Acar, Fatma Fidan
Evaluation of the Upper Airway Cross-sectional Area Changes in Different Degrees of Severity of Obstructive Sleep Apnea Syndrome: Cephalometric and Dynamic CT Study
American Journal of Neuroradiology Nov 2005, 26 (10) 2624-2629;

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Evaluation of the Upper Airway Cross-sectional Area Changes in Different Degrees of Severity of Obstructive Sleep Apnea Syndrome: Cephalometric and Dynamic CT Study
Aylin Yucel, Mehmet Unlu, Alpay Haktanir, Murat Acar, Fatma Fidan
American Journal of Neuroradiology Nov 2005, 26 (10) 2624-2629;
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