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Research ArticleSpine Imaging and Spine Image-Guided Interventions

Incidence of Vertebral Artery Thrombosis in Cervical Spine Trauma: Correlation with Severity of Spinal Cord Injury

Philip J. Torina, Adam E. Flanders, John A. Carrino, Anthony S. Burns, David P. Friedman, James S. Harrop and Alexander R. Vacarro
American Journal of Neuroradiology November 2005, 26 (10) 2645-2651;
Philip J. Torina
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Adam E. Flanders
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John A. Carrino
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Anthony S. Burns
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David P. Friedman
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James S. Harrop
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Alexander R. Vacarro
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    Fig 1.

    A 58-year-old man who sustained a unilateral interfacetal dislocation at C5–C6 without SCI.

    A, Sagittal T2-weighted fast spin-echo (FSE) image (TR/TE/ETL: 2000/80/8) shows an injured disk at C5–C6 with increased signal intensity in the disk and probably avulsion of the anterior longitudinal ligament (dashed arrow). Prevertebral edema (arrowheads) and edema in the posterior paraspinal musculature (white arrows) are present.

    B, Nonvisualization of the right vertebral artery. MIP image (anterior view) from a 2D time-of-flight acquisition (TR/TE/flip: 40/8.7/30) shows absence of signal intensity in the expected course of the right vertebral artery (dotted line).

    C, Thrombus in the right foramen transversarium. Axial image from a 3D GRE acquisition (TR/TE/flip: 37/min/15) shows an oval area of low signal intensity in the right foramen transversarium corresponding to thrombus in the right vertebral artery. Note the normal flow-related enhancement in the left foramen transversarium.

    D, Thombus in the right vertebral artery. Axial FSE image (TR/TE/ETL: 3000/28/4) obtained at a similar level to image in panel C shows a high-signal-intensity thrombus (arrow) in the right foramen transversarium indicative of a thrombosed vertebral artery. Note the normal flow void of the left vertebral artery in the left foramen transversarium.

Tables

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    TABLE 1:

    The ASIA classification of neurologic impairment

    ASIA GradeDescription
    ANo motor or sensory function preserved in the sacral segments
    BSensory but not motor function preserved in at least the sacral segments
    CMotor function preserved below the neurologic level and most key muscles have motor score <3
    DMotor function preserved below the neurologic level and most key muscles have a motor score of ≥3
    EMotor and sensory function is normal.
    • Note.—ASIA indicates American Spinal Injury Association. Adapted from Ditunno (6).

    • View popup
    TABLE 2:

    Demographic summary of study population, including ASIA impairment grade, etiology, level of bony injury, and neurologic level of injury

    (N = 63)% (n)
    Patients
        Male71 (449)
        Female29 (183)
        Mean age (y)48.6 (12–102)
    ASIA impairment grade
        A34 (115)
        B13 (42)
        C25 (83)
        D28 (94)
        E47 (298)
    Etiology
        Fall43 (270)
        Automobile crash34 (213)
        Not specified7 (46)
        Diving accident6 (39)
        Pedestrian accident3 (17)
        Assault2 (13)
        Sports injury2 (13)
        Motorcycle crash2 (12)
        Projectile1 (9)
    Level of bony injury
        C13 (32)
        C25 (52)
        C39 (82)
        C418 (168)
        C526 (246)
        C626 (247)
        C713 (120)
    Neurologic level of injury
        C22 (11)
        C33 (16)
        C422 (141)
        C516 (103)
        C68 (49)
        C72 (11)
        C80.5 (3)
        No level (ASIA E)47 (298)
    • Note.—ASIA indicates American Spinal Injury Association.

      Multiple fractures were possible in individual patients.

    • View popup
    TABLE 3:

    Demographic data of patients with proved vertebral artery thrombosis (VAT), including ASIA impairment grade, etiology, level of bone injury, and neurologic level of injury

    (N = 83)% (n)
    Patients with VAT
        Male76 (63)
        Female24 (20)
        Mean age (y)44 (14–88)
    Vertebral artery affected
        Left48 (42)
        Right43 (37)
        Both9 (4)
    ASIA impairment grade
        A30 (25)
        B7 (6)
        C11 (9)
        D11 (9)
        E41 (34)
    Etiology
        Automobile crash45 (37)
        Fall28 (23)
        Sports injury12 (10)
        Other15 (13)
    Level of bony injury
        C13 (5)
        C24 (6)
        C36 (10)
        C421 (34)
        C533 (55)
        C624 (39)
        C79 (14)
    Neurologic level of injury
        C35 (3)
        C428 (23)
        C518 (15)
        C66 (5)
        C71 (2)
        C81 (2)
        No neurologic level41 (34)
    • Note.—ASIA indicates American Spinal Injury Association.

      Multiple fractures were possible in individual patients.

    • View popup
    TABLE 4:

    Comparison of patient demographics, ASIA neurologic impairment score, and neurologic level of injury for patients included and excluded from analysis

    IncludedExcludedTotal
    Number6356481280*
    Average age (y)4953102
        Male452408860
        Female183240423
    ASIA impairment grade
        A11592207
        B422971
        C8357140
        D9449143
        E298417715
    Level of injury
        C1066
        C2111829
        C3161935
        C414181222
        C510461165
        C6502171
        C7111728
        C8369
    • Note.—ASIA indicates American Spinal Injury Association. Populations differed statistically with respect to sexual distribution (P < .01) and neurologic level (P < .001), but not for age (P < 1) or neurologic deficit (ASIA impairment grades A–D, P <.939).

    • * Three patients were excluded because of unavailable clinical data.

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American Journal of Neuroradiology: 26 (10)
American Journal of Neuroradiology
Vol. 26, Issue 10
1 Nov 2005
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Philip J. Torina, Adam E. Flanders, John A. Carrino, Anthony S. Burns, David P. Friedman, James S. Harrop, Alexander R. Vacarro
Incidence of Vertebral Artery Thrombosis in Cervical Spine Trauma: Correlation with Severity of Spinal Cord Injury
American Journal of Neuroradiology Nov 2005, 26 (10) 2645-2651;

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Incidence of Vertebral Artery Thrombosis in Cervical Spine Trauma: Correlation with Severity of Spinal Cord Injury
Philip J. Torina, Adam E. Flanders, John A. Carrino, Anthony S. Burns, David P. Friedman, James S. Harrop, Alexander R. Vacarro
American Journal of Neuroradiology Nov 2005, 26 (10) 2645-2651;
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