Research ArticleBRAIN
Age-Related Changes in Normal-Appearing Brain Tissue and White Matter Hyperintensities: More of the Same or Something Else?
Aart Spilt, Tychon Geeraedts, Anton J. M. de Craen, Rudi G. J. Westendorp, Gerard J. Blauw and Mark A. van Buchem
American Journal of Neuroradiology April 2005, 26 (4) 725-729;
Aart Spilt
Tychon Geeraedts
Anton J. M. de Craen
Rudi G. J. Westendorp
Gerard J. Blauw

References
- ↵Meyer JS, Kawamura J, Terayama Y. White matter lesions in the elderly. J Neurol Sci 1992;110:1–7
- ↵de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study—the Rotterdam scan study. J Neurol Neurosurg Psychiatry 2001;70:9–14
- ↵de Leeuw FE, de Groot JC, Oudkerk M, et al. Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. Stroke 2000;31:425–429
- ↵Longstreth WT Jr, Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: the Cardiovascular Health Study. Stroke 1996;27:1274–1282
- ↵Grossman RI, Gomori JM, Ramer KN, Lexa FJ, Schnall MD. Magnetization transfer: theory and clinical applications in neuroradiology. Radiographics 1994;14:279–290
- ↵van Buchem MA, Udupa JK, McGowan JC, et al. Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging. AJNR Am J Neuroradiol 1997;18:1287–1290
- ↵Kucharczyk W, Macdonald PM, Stanisz GJ, Henkelman RM. Relaxivity and magnetization transfer of white matter lipids at MR imaging: importance of cerebrosides and pH. Radiology 1994;192:521–529
- ↵Scheltens P, Barkhof F, Leys D, Wolters EC, Ravid R, Kamphorst W. Histopathologic correlates of white matter changes on MRI in Alzheimer’s disease and normal aging. Neurology 1995;45:883–888
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. The morphologic correlate of incidental punctate white matter hyperintensities on MR images. AJNR Am J Neuroradiol 1991;12:915–921
- ↵Braffman BH, Zimmerman RA, Trojanowski JQ, Gonatas NK, Hickey WF, Schlaepfer WW. Brain MR: pathologic correlation with gross and histopathology, II: hyperintense white-matter foci in the elderly. AJR Am J Roentgenol 1988;151:559–566
- ↵Silver NC, Barker GJ, MacManus DG, Tofts PS, Miller DH. Magnetisation transfer ratio of normal brain white matter: a normative database spanning four decades of life. J Neurol Neurosurg Psychiatry 1997;62:223–228
- ↵Shepherd J, Blauw GJ, Murphy MB, et al. The design of a prospective study of pravastatin in the elderly at risk (PROSPER): PROSPER study group—Prospective Study of Pravastatin in the Elderly at Risk. Am J Cardiol 1999;84:1192–1197
- ↵Scheltens P, Barkhof F, Leys D, et al. A semiquantitative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993;114:7–12
- ↵Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992;182:483–491
- ↵Bosma GP, Rood MJ, Zwinderman AH, Huizinga TW, van Buchem MA. Evidence of central nervous system damage in patients with neuropsychiatric systemic lupus erythematosus, demonstrated by magnetization transfer imaging. Arthritis Rheum 2000;43:48–54
- ↵van Buchem MA, Grossman RI, Armstrong C, et al. Correlation of volumetric magnetization transfer imaging with clinical data in MS. Neurology 1998;50:1609–1617
- ↵van Buchem MA, McGowan JC, Kolson DL, Polansky M, Grossman RI. Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magn Reson Med 1996;36:632–636
- ↵Hofman PA, Kemerink GJ, Jolles J, Wilmink JT. Quantitative analysis of magnetization transfer images of the brain: effect of closed head injury, age and sex on white matter. Magn Reson Med 1999;42:803–806
- Rovaris M, Iannucci G, Cercignani M, et al. Age-related changes in conventional, magnetization transfer, and diffusion-tenser MR imaging findings: study with whole-brain tissue histogram analysis. Radiology 2003;227:731–738
- ↵Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ, Kolson DL. Age-related total gray matter and white matter changes in normal adult brain, II: quantitative magnetization transfer ratio histogram analysis. AJNR Am J Neuroradiol 2002;23:1334–1341
- ↵Tanabe JL, Ezekiel F, Jagust WJ, Schuff N, Fein G. Volumetric method for evaluating magnetization transfer ratio of tissue categories: application to areas of white matter signal hyperintensity in the elderly. Radiology 1997;204:570–575
- Tanabe JL, Ezekiel F, Jagust WJ, et al. Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. AJNR Am J Neuroradiol 1999;20:839–844
- Wong KT, Grossman RI, Boorstein JM, Lexa FJ, McGowan JC. Magnetization transfer imaging of periventricular hyperintense white matter in the elderly. AJNR Am J Neuroradiol 1995;16:253–258
- Hanyu H, Asano T, Sakurai H, et al. Magnetization transfer ratio in cerebral white matter lesions of Binswanger’s disease. J Neurol Sci 1999;166:85–90
- ↵Mehta RC, Pike GB, Enzmann DR. Measure of magnetization transfer in multiple sclerosis demyelinating plaques, white matter ischemic lesions, and edema. AJNR Am J Neuroradiol 1996;17:1051–1055
- ↵Bronge L, Bogdanovic N, Wahlund LO. Postmortem MRI and histopathology of white matter changes in Alzheimer brains; a quantitative, comparative study. Dement Geriatr Cogn Disord 2002;13:205–212
- Nusbaum AO, Tang CY, Buchsbaum MS, Wei TC, Atlas SW. Regional and global changes in cerebral diffusion with normal aging. AJNR Am J Neuroradiol 2001;22:136–142
- ↵Firbank MJ, Minnett T, O’Brien J. Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. Neurology. 2003;61:950–954
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Aart Spilt, Tychon Geeraedts, Anton J. M. de Craen, Rudi G. J. Westendorp, Gerard J. Blauw, Mark A. van Buchem
Age-Related Changes in Normal-Appearing Brain Tissue and White Matter Hyperintensities: More of the Same or Something Else?
American Journal of Neuroradiology Apr 2005, 26 (4) 725-729;
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