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Research ArticleBrain

Age and Sex Variability and Normal Reference Values for the VMCA/VICA Index

Jaroslaw Krejza, Piotr Szydlik, David S. Liebeskind, Jan Kochanowicz, Oleg Bronov, Zenon Mariak and Elias R. Melhem
American Journal of Neuroradiology April 2005, 26 (4) 730-735;
Jaroslaw Krejza
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Piotr Szydlik
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David S. Liebeskind
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Jan Kochanowicz
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Oleg Bronov
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Zenon Mariak
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Elias R. Melhem
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    Fig 1.

    Distribution of values of the VMCA/VICA index, calculated from the mean MCA and ipsilateral extracranial ICA velocities in women and men in three age groups (<40, 40–60, and >60 years) and in 304 healthy subjects. In women, median value of the index increases with age to 60 years, whereas in men, it is relatively stable. The minimum and maximum values of the variable are indicated by the whiskers (solid lines) of each diagram. The median value is indicated by a central horizontal and the lower and upper qualities by the corresponding horizontal ends of the box. *Indicates outlying value, inconsistent with other points in the sample.

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    Fig 2.

    Distribution of mean blood flow velocities in the MCA for women and men in the three age groups and in 304 healthy subjects. Mean velocity is higher in women up to the age of 60 years, and in older subjects, mean velocities are substantially lower and similar in both sexes. A description of box-and-whisker plot is provided in Figure 1.

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    Fig 3.

    Distribution of mean blood flow velocities in the extracranial ICA for women and for men in the three age groups and in all 304 healthy subjects. Mean velocity is substantially high in women up to the age of 60 years; after this time, velocity decreases significantly. A different pattern of age dependence is seen in men: flow velocity is almost stable throughout the life span. A description of box-and-whisker plot is provided in Figure 1.

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    TABLE 1:

    Normal reference values for mean MCA and ICA blood flow velocities by age group

    Mean Velocity (cm/s)Age GroupBetween-Group Differences
    AllI (<40 y)II (40–60 y)III (>60 y)
    All subjects (n = 304)
        MCA71 (35–107)**78 (44–112)70 (36–104)57 (32–82)I vs II†, II vs III†, I vs III†
        ICA39 (18–60)**43 (28–61)38 (16–60)33 (16–50)I vs II†, II vs III†, I vs III†
    Women (n = 193)
        MCA75 (39–111)**80 (45–115)‡74 (41–107)58 (31–85)II vs III†, I vs III†
        ICA42 (20–64)*45 (28–62)‡42 (17–67)31 (12–50)I vs II†, II vs III†, I vs III†
    Men (n = 111)
        MCA64 (32–96)**71 (40–102)65 (32–98)56 (31–81)I vs III†
        ICA34 (20–48)*35 (21–49)34 (20–48)34 (20–48)Not significant
    • * Age dependence, P < .05.

    • ** Age dependence, P < .001.

    • † All P < .05.

    • ‡ Sex dependence, P < .05.

    • View popup
    TABLE 2:

    Normal reference values for the VMCA/VICA index by age group

    VMCA/VICA IndexAge GroupBetween-Group Differences
    AllI (<40 y)II (40–60 y)III (>60 y)
    All subjects (n = 304)
        Peak systole1.73 (0.72–2.74)*1.68 (0.76–2.60)1.78 (0.76–2.80)1.77 (0.60–2.94)Not significant
        Mean1.91 (0.81–3.01)1.88 (0.86–2.90)1.96 (0.84–3.10)1.90 (0.67–3.13)Not significant
        End diastole1.99 (0.73–3.15)1.94 (0.80–3.08)2.06 (0.65–3.47)2.00 (0.68–3.32)Not significant
    Women (n = 193)
        Peak systole1.70 (0.74–2.66)*1.62 (0.76–2.44)†1.78 (0.96–2.60)1.89 (0.51–3.27)I vs III‡
        Mean1.87 (0.82–2.92)*1.82 (0.88–2.76)†1.91 (0.94–2.88)2.06 (0.59–3.53)I vs III‡
        End diastole1.93 (0.78–3.08)*1.86 (0.84–2.88)†1.96 (0.82–3.10)2.17 (0.66–3.68)I vs III‡
    Men (n = 111)
        Peak systole1.77 (0.69–2.85)1.85 (0.82–2.88)1.78 (0.53–3.01)1.68 (0.72–2.64)Not significant
        Mean1.98 (0.80–3.16)2.10 (0.96–3.24)2.04 (0.71–3.37)1.78 (0.81–2.75)Not significant
        End diastole2.08 (0.66–3.50)2.20 (0.83–3.57)2.19 (0.51–3.87)1.86 (0.85–2.87)Not significant
    • * Age dependence, P < .001.

    • † Sex dependence, P < .05.

    • ‡ P < .05.

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American Journal of Neuroradiology: 26 (4)
American Journal of Neuroradiology
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1 Apr 2005
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Cite this article
Jaroslaw Krejza, Piotr Szydlik, David S. Liebeskind, Jan Kochanowicz, Oleg Bronov, Zenon Mariak, Elias R. Melhem
Age and Sex Variability and Normal Reference Values for the VMCA/VICA Index
American Journal of Neuroradiology Apr 2005, 26 (4) 730-735;

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Age and Sex Variability and Normal Reference Values for the VMCA/VICA Index
Jaroslaw Krejza, Piotr Szydlik, David S. Liebeskind, Jan Kochanowicz, Oleg Bronov, Zenon Mariak, Elias R. Melhem
American Journal of Neuroradiology Apr 2005, 26 (4) 730-735;
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