Article Figures & Data
Figures
- Fig 1.
Anaplastic astrocytoma. Axial enhanced T1–weighted image demonstrates a right frontal, nonenhancing lesion (A). rCBV map shows a markedly elevated rCBV of 3.6, which is consistent with biopsy-proved anaplastic astrocytoma (B). Immunohistochemical staining (400×) with monoclonal antibody against VEGF reveals strong cellular and endothelial positivity (C).
- Fig 2.
Diffuse astrocytoma. Axial enhanced T2-weighted image shows a left frontal nonenhancing lesion (A). rCBV map shows an obviously reduced rCBV of 0.72, which is consistent with biopsy-proved diffuse astrocytoma (WHO grade II). Immunohistochemical staining (400×) with the monoclonal antibody against VEGF is negative (C).
- Fig 3.
Diffuse astrocytoma. Axial enhanced T1-weighted image shows a left frontal nonenhancing lesion (A). rCBV map shows an elevated rCBV of 1.9 (B). Histologic section (400×) reveals a diffuse astrocytoma (WHO grade II), but VEGF staining shows strong cellular and endothelial positivity (C).
- Fig 4.
Anaplastic astrocytoma. Coronal enhanced T1-weighted image shows a heterogeneous left frontal lesion (A). rCBV map demonstrates a focal area with a high rCBV of 3.11. Histologic section (400X) of this focus is consistent with biopsy-proved anaplastic astrocytoma, and VEGF staining shows strong cellular and endothelial positivity (C).
Tables
rCBV ratios, histologic results, and VEGF expression
Patient/Sex/Age (y) Histology rCBV* VEGF WHO grade II 1/M/30 Diffuse astrocytoma 0.65/0.77 − 2/M/35 Diffuse astrocytoma 0.55/0.72 − 3/F/33 Diffuse astrocytoma 0.57/0.7 − 4/M/27 Diffuse astrocytoma 0.69/0.81 − 5/M/41 Diffuse astrocytoma 0.62/0.65 − 6/M/39 Diffuse astrocytoma 1.73/2.1 + 7/M/38 Diffuse astrocytoma 1.07/1.2 + 8/F/22 Diffuse astrocytoma 1.61/1.9 + 9/M/32 Diffuse astrocytoma 0.68/0.82 − 10/M/39 Oligodendroglioma 1.27/1.62 − 11/M/26 Oligoastrocytoma 1.72/1.88 − 12/F/37 Oligoastrocytoma 1.59/1.97 + 13/M/27 Oligoastrocytoma 2.64/2.99 + WHO grade III 14/M/42 Anaplastic astrocytoma 2.78/3.11 + 15/M/30 Anaplastic astrocytoma 2.89/3.08 + 16/M/58 Anaplastic astrocytoma 3.45/3.6 + 17/F/55 Anaplastic astrocytoma 3.79/3.9 + 18/M/25 Anaplastic astrocytoma 3.22/3.7 + 19/M/56 Anaplastic astrocytoma 3.30/3.8 + 20/M/25 Anaplastic oligoastrocytoma 2.99/3.19 + * Mean/maximum.
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