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Research ArticleBrain

Can Tumor Contrast Enhancement Be Used as a Criterion for Differentiating Tumor Grades of Oligodendrogliomas?

Matthew L. White, Yan Zhang, Patricia Kirby and Timothy C. Ryken
American Journal of Neuroradiology April 2005, 26 (4) 784-790;
Matthew L. White
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Yan Zhang
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Patricia Kirby
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Timothy C. Ryken
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  • Fig 1.
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    Fig 1.

    Anaplastic oligodendroglioma obtained in a 28-year-old man.

    A, Axial T2-weighted (3588/99 TR/TE) fast SE image shows a high-signal-intensity mass in the left frontal lobe.

    B, Axial T1-weighted (540/14) image shows that the mass has low signal intensity.

    C, Axial contrast-enhanced T1-weighted (540/14) image shows nodular-like enhancement within the mass.

    D, Photomicrograph of the specimen (hematoxylin-eosin stain; original magnification, x25) shows a nodular area that has the high-grade features consisting of high cellularity and nuclear hyperchromasia; however, this is not a specifically sampled area of the nodular-like enhancement on the T1-weighted image. Note the area of necrosis (arrows).

    E, Photomicrograph of the specimen (hematoxylin-eosin stain; original magnification, x25) shows the area that has the relatively low-grade features, such as even cellularity and little nuclear pleomorphism. No necrosis is present.

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    Fig 2.

    Anaplastic oligodendroglioma in a 47-year-old woman.

    A, Axial T2-weighted (3200/96) fast SE image shows a high-signal-intensity mass that mainly involves the right frontal lobe and insula.

    B, Axial T1-weighted (583/20) image shows that the mass is isointense to slightly hypointense.

    C, Axial contrast-enhanced T1-weighted (583/20) image does not show obvious tumor contrast enhancement. The CER is 5.82.

    D, Photomicrograph of the specimen (hematoxylin-eosin stain; original magnification x40) shows high cellularity, nuclear pleomorphism and hyperchromasia, and mitosis (arrow). There is no increased neovascularity.

  • Fig 3.
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    Fig 3.

    Low-grade oligodendroglioma in a 42-year-old man.

    A, Axial T2-weighted (4750/105) fast SE image shows a high-signal-intensity mass in the right frontal lobe.

    B, Axial T1-weighted (466/14) image shows that the mass is isointense to slightly hyperintense.

    C, Axial contrast-enhanced T1-weighted (466/14) image shows partial tumor contrast enhancement. The contrast enhancement ratio is 40.88.

    D, Photomicrograph of the specimen (hematoxylin-eosin stain; original magnification, x40) shows even cellularity and little nuclear pleomorphism and hyperchromasia. No mitosis or necrosis is present. There is no increased neovascularity.

  • Fig 4.
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    Fig 4.

    Anaplastic oligodendroglioma in a 59-year-old man.

    A, Axial T2-weighted (3986/99) fast SE image shows a high-signal-intensity mass in the right temporal and frontal lobes.

    B, Axial T1-weighted (600/14) image shows that the mass is isointense to slightly hyperintense.

    C, Axial contrast-enhanced T1-weighted (600/14) image shows the inhomogeneous and partial tumor contrast enhancement with a CER up to 62.52. There are nodular-like enhancement areas within the tumor.

    D, Photomicrograph of the specimen (hematoxylin-eosin stain; original magnification, x100) shows an area with high cellularity and increased neovascularity.

Tables

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    TABLE 1:

    Histologic classification of oligodendrogliomas

    Type of SpecimenTumor GradeTotal
    Low-gradeAnaplastic
    Biopsy415
    Resection12719
    Total16824
    • View popup
    TABLE 2:

    Contrast enhancement in oligodendrogliomas

    Tumor GradeEnhancement*No Enhancement
    Anaplastic (n = 8)5† (3)3
    Resected low-grade (n = 12)6 (1)6‡
    • * Numbers in parentheses are the number of tumors with increased neovascularity.

    • † Sensitivity is 63%.

    • ‡ Specificity is 50%.

    • View popup
    TABLE 3:

    CERs for 12 oligodendrogliomas

    Low-Grade (n = 6)Anaplastic (n=6)
    2.123.20
    17.245.82
    17.7715.86
    17.8738.35*
    24.5846.63†
    40.8862.52*
    20.08‡28.73‡
    • * Tumors with increased vascularity.

    • † This tumor was proved only by biopsy; all others were proved by resection.

    • ‡ Mean CER of each tumor group.

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American Journal of Neuroradiology: 26 (4)
American Journal of Neuroradiology
Vol. 26, Issue 4
1 Apr 2005
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Matthew L. White, Yan Zhang, Patricia Kirby, Timothy C. Ryken
Can Tumor Contrast Enhancement Be Used as a Criterion for Differentiating Tumor Grades of Oligodendrogliomas?
American Journal of Neuroradiology Apr 2005, 26 (4) 784-790;

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Can Tumor Contrast Enhancement Be Used as a Criterion for Differentiating Tumor Grades of Oligodendrogliomas?
Matthew L. White, Yan Zhang, Patricia Kirby, Timothy C. Ryken
American Journal of Neuroradiology Apr 2005, 26 (4) 784-790;
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