Article Figures & Data
Figures
- Fig 1.
Patient 8 with atypical vascular proliferation of the vocal cord.
A, Contrast-enhanced neck CT scan shows a mass in the left true vocal cord. ROIs 9 and 11–13 are in the lesion, and ROI 10 is in the contralateral vocal cord.
B, CTP functional map shows a relatively low blood flow of 26–32 mL/100 g/min in the lesion in the left vocal cord. Right vocal cord has blood flow of 26 mL/100 g/min. Scale from red to blue corresponds to decreasing flow.
C, CTP functional map shows that the lesion has a relatively long MTT of 6.9–11.6 seconds. Scale from red to blue corresponds to increasing MTT.
- Fig 2.
Patient 3 with surgically treated acinic cell cancer of the parotid gland.
A, Rater 1. Contrast-enhanced neck CT scan shows a mass in the suboccipital subcutaneous fat (arrow) that was a suspected metastatic lymph node. Histology showed fat necrosis and chronic inflammation. ROIs are placed on the lesion (1) and on the masseter (3) and paraspinal (5) muscles.
B, Rater 2. CTP functional map shows relatively low blood flow of 24.9 mL/100 g/min in the lesion (arrow, ROI 1) and shows ROIs in the masseter (4) and paraspinal (8 and 9) muscles. Scale from red to blue corresponds to decreasing flow.
C, Rater 2. CTP functional map shows that the lesion (arrow, ROI 1) has a relatively long MTT of 10.5 seconds and shows ROIs in the masseter (4) and paraspinal (8 and 9) muscles. Scale from red to blue corresponds to increasing MTT.
- Fig 3.
Patient 12 with primary gingival squamous cell cancer.
A, Contrast-enhanced neck CT scan shows a mass on both sides of the left mandibular body (arrows).
B, Lesion is more conspicuous on the CTP functional map, which reveals a high blood flow of 96–144 mL/100 g/min. Scale from red to blue corresponds to decreasing flow.
C, CTP functional map shows that the lesion has a short MTT of 2.1–5.4 seconds. Scale from red to blue corresponds to increasing MTT. The ROIs were placed within the lesion (8 and 9), paraspinal muscles (10), and left parotid gland (11).
- Fig 4.
Patient 13 with recurrent laryngeal squamous cell cancer previously treated with radiation.
A, Contrast-enhanced neck CT scan shows thickening and diffuse enhancement of supralaryngeal structures. ROIs 1 and 2 are placed bilaterally in the abnormality. Both sampled sites were positive for recurrence on histology. ROI 4 is in the left sternocleidomastoid muscle.
B, CTP functional map reveals areas of increased perfusion with blood flows of 67 and 77 mL/100 g/min. Scale from red to blue corresponds to decreasing flow.
C, CTP functional map shows short MTTs of 2.5 and 3.4 seconds in the abnormality. Scale from red to blue corresponds to decreasing MTT.
Tables
Patient/Age (y)/Sex Pathology History 1/74/M Retromolar trigone squamous cell cancer Not applicable 2/28/M Fat necrosis Surgically treated parotid gland acinic cell cancer 3/43/M Floor-of-the-mouth squamous cell cancer Not applicable 4/56/M Granulation tissue, chronic inflammation Oropharyngeal squamous cell cancer treated with chemoirradiation 5/17/F Parotid pleomorphic adenoma Not applicable 6/63/M Chronic inflammation Diffuse large cell B lymphoma treated with chemotherapy 7/40/M Vocal cord, atypical vascular proliferation Not applicable 8/74/F Goiter Not applicable 9/68/M Orbital alveolar rhabdomyosarcoma Not applicable 10/56/F Active chronic inflammation of hypopharynx Not applicable 11/58/M Gingival squamous cell cancer Not applicable 12/80/F Recurrent larynegeal squamous cell cancer Previously treated with chemoirradiation ROI Intrareader Interreader Ipsilateral vs Contralateral ICA ICA vs ECA Between Subjects Primary site .87 .35 .91 .57 .002 Salivary glands* .80 .58 .89 .56 .13 Masseter muscle .87 .60 .93 .82 .09 Sternocleidomastoid .51 .37 .88 .79 <.0001 Paraspinal muscles .98 .81 .99 .81 <.0001 * Parotid and submandibular glands.
ROI Perfusion Parameters Blood Flow (mL/100g/min) Blood volume (mL/100g) MTT (sec) CP (mL/100g/min) Muscles of mastication 14.7 ± 14.4* 1.5 ± 0.4* 16.1 ± 8.8* 9.0 ± 4.7* Paraspinous muscles 4.7 ± 2.7* 1.1 ± 0.6* 20.8 ± 6.9* 6.5 ± 5.3* Sternocleidomastoid muscle 16.4 ± 10.1* 1.4 ± 0.7‡ 10.6 ± 5.1* 5.4 ± 4.0* Thyroid gland 154.5 ± 41.8 14.0 ± 2.0* 6.3 ± 0.6* 29.7 ± 8.8 Salivary glands† 51.7 ± 39.7 4.2 ± 1.9 8.2 ± 4.1‡ 37.9 ± 12.6‡ Malignant lesions 94.9 ± 47.9 4.4 ± 2.2 3.3 ± 0.9 23.2 ± 4.6 Benigh lesions 38.5 ± 16.8‡ 3.8 ± 1.2 11.8 ± 4.5* 24.3 ± 9.2 Note.—Data are the mean ± standard deviation. CP = capillary permeability surface product.
* P < .001, malignant lesions vs other structures.
† Parotid and submandibular glands.
‡ P < .05, malignant lesions vs other structures.
Study Method Cases Perfusion Parameters Blood Flow (mL/100g/min) Blood Volume (mL/100g) MTT (sec) CP (mL/100g/min) Present Deconvolution 4 101.9 ± 34.6 5.6 ± 1.6 3.2 ± 1.2 24.1 ± 4.8 Gandhi et al, 200314 Deconvolution 14 126.2 ± 78.4 5.8 ± 3.8 3.9 ± 2.0 40.6 ± 22.5 Hermans et al, 200315 Compartmental 105 88.5 ± 46.5 NA NA NA Hermans et al, 199916 Compartmental 41 86.4 ± 43 NA NA NA Hermans et al, 199717 Compartmental 18 75.7 ± 27.7 NA NA NA Note.—Data are the mean ± standard deviation. CP = capillary permeability surface product, NA = not applicable.
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