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Research ArticleINTERVENTIONAL

Acute and Chronic Swine Rete Arteriovenous Malformation Models: Hemodynamics and Vascular Remodeling

A. K. Wakhloo, B. B. Lieber, R. Siekmann, D. J. Eber and M. J. Gounis
American Journal of Neuroradiology August 2005, 26 (7) 1702-1706;
A. K. Wakhloo
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B. B. Lieber
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R. Siekmann
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D. J. Eber
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M. J. Gounis
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    Fig 1.

    Illustration of the perfusion apparatus used in the chronic swine AVM model.

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    Fig 2.

    A, High-resolution radiograph of a rete in the chronic swine AVM model embolized with a 50/50 + 20 μL acrylate mixture (NBCA/Lipiodol/glacial acetic acid). Red line indicates the area of cross-section for histology.

    B, Corresponding histology (hematoxylin-eosin stain) for vessel measurements shows most of the arteries of the rete network filled with acrylate mixture (arrow).

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    Fig 3.

    Vessel diameters of nontreated swine retia (controls).

    A, Schematic of a rete with section lines demarcating sectors for vessel measurements (AP, ascending pharyngeal artery; CCA, common carotid artery).

    B, Graph shows the corresponding vessel diameters in each region for a 35-kg (diamonds) and 100-kg (squares) swine. Error bars indicate the standard error of mean.

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  • Hemodynamic parameters in an acute and a chronic swine rete AVM model

    Acute ModelChronic ModelP Value
    Age (months)3.9 ± 3.212.4 ± 0.5<.0001
    Weight (kg)46.9 ± 22.7213.7 ± 25.9<.001
    Pressure grandient (mm Hg)15.4 ± 1.423.7 ± 12.0.085
    Rete outflow (mL/min)32.5 ± 17.57139.9 ± 100.29.030
    Rete length (pixel)401.3 ± 65.2593.1 ± 39.9<.001
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American Journal of Neuroradiology: 26 (7)
American Journal of Neuroradiology
Vol. 26, Issue 7
1 Aug 2005
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Cite this article
A. K. Wakhloo, B. B. Lieber, R. Siekmann, D. J. Eber, M. J. Gounis
Acute and Chronic Swine Rete Arteriovenous Malformation Models: Hemodynamics and Vascular Remodeling
American Journal of Neuroradiology Aug 2005, 26 (7) 1702-1706;

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Acute and Chronic Swine Rete Arteriovenous Malformation Models: Hemodynamics and Vascular Remodeling
A. K. Wakhloo, B. B. Lieber, R. Siekmann, D. J. Eber, M. J. Gounis
American Journal of Neuroradiology Aug 2005, 26 (7) 1702-1706;
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