Research ArticlePEDIATRICS
A Quantitative MR Imaging Assessment of Leukoencephalopathy in Children Treated for Acute Lymphoblastic Leukemia without Irradiation
Wilburn E. Reddick, John O. Glass, Kathleen J. Helton, James W. Langston, Chin-Shang Li and Ching-Hon Pui
American Journal of Neuroradiology October 2005, 26 (9) 2371-2377;
Wilburn E. Reddick
John O. Glass
Kathleen J. Helton
James W. Langston
Chin-Shang Li

References
- ↵Pui C-H, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004;350:1535–1548
- ↵Shuper A, Stark B, Kornreich L, et al. Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoglastic leukemia. Isr Med Assoc J 2002;4:1050–1053
- ↵Asato R, Akiyama Y, Ito M, et al. Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 1992;70:1997–2004
- ↵Paakko E, Harila-Saari A, Vanionpaa L, et al. White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings. Med Pediatr Oncol 2000;35:456–461
- ↵Chu WCW, Chik KW, Chan YL, et al. White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy. Radiology 2003;229:659–669
- ↵Wilson DA, Nitschke R, Bowman ME, et al. Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficencies. Radiology 1991;180:205–209
- ↵Kingma A, Mooyaart EL, Kamps WA, et al. Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age. Am J Pediatr Hematol Oncol 1993;15:231–238
- ↵Kingma A, van Dommelen RI, Mooyaart EL, et al. Slight cognitive impairment and magnetic resonance imaging abnormalities but normal school levels in children treated for acute lymphoblastic leukemia with chemotherapy only. J Pediatr 2001;139:413–420
- ↵Reddick WE, Glass JO, Helton KJ, et al. Prevalence of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate. AJNR Am J Neuroradiol 2004;26:1263–1269
- ↵Evans WE, Relling MV, Rodman JH, et al. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 1998;338:499–505
- ↵
- ↵
- Steen RG, Gronemeyer SA, Taylor JS. Age-related changes in proton T1 values of normal brain. J Magn Reson Imaging 1995;5:43–48
- ↵Cho S, Jones D, Reddick WE, Ogg RJ, Steen RG. Establishing norms for age-related changes in proton T1 of human brain tissue in vivo. Magn Reson Imaging 1997;15:1133–1143
- ↵Ostuni JL, Levin RL, Frank JA, DeCarli C. Correspondence of closest gradient voxels: a robust registration algorithm. J Magn Reson Imaging 1997;7:410–415
- ↵Ji Q, Reddick WE, Glass JO, Krynetskiy E. Quantitative study of renormalization transformation method to correct the inhomogeneity in MR images. SPIE Medical Imaging Symposium; February2002; San Diego, CA
- ↵Reddick WE, Glass JO, Cook EN, et al. Automated segmentation and classification of multispectral magnetic resonance images of brain using artifical neural networks. IEEE Trans Med Imaging 1997;16:911–918
- ↵Reddick WE, Glass JO, Langston JW, Helton KJ. Quantitative MRI assessment of leukoencephalopathy. Magn Reson Med 2002;47:912–920
- ↵
- ↵Reddick WE, Glass JO, Pui C-H. Differentiating therapy-indued leukoencephalopathy from unmyelinated white matter in children treated for acute lymphoblastic leukemia (ALL). Presented at: 11th scientific meeting of the International Society of Magnetic Resonance in Medicine, Toronto, Ontario, Canada, July10–16,2003
- ↵Rolllins N, Winick N, Bash R, Booth T. Acute methotrexate neurotoxicity: findings on diffusion-weighted imaging and correlation with clinical outcome. AJNR Am J Neuroradiol 2004;25:1688–1695
- ↵Kishi S, Griener JC, Cheng C, et al. Homocysteine, pharmacogenetics, and neurotoxicity in children with leukemia. J Clin Oncol 2003;21:3084–3091
- ↵Montour-Proulx I, Kuehn SM, Keene DL, et al. Cognitive changes in children treated for acute lymphoblastic leukemia with chemotherapy only according to the pediatric oncology group 9605 protocol. J Child Neurol 2005;20:129–133
- ↵Desmond DM. Cognition and white matter lesions. Cerebrovasc Dis 2002;13:53–57
- ↵Steen RG, Gronemeyer SA, Kingsley PB, et al. Precise and accurate measurement of proton T1 in human brain in vivo: validation and preliminary clinical application. J Magn Reson Imaging 1994;4:681–691
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Wilburn E. Reddick, John O. Glass, Kathleen J. Helton, James W. Langston, Chin-Shang Li, Ching-Hon Pui
A Quantitative MR Imaging Assessment of Leukoencephalopathy in Children Treated for Acute Lymphoblastic Leukemia without Irradiation
American Journal of Neuroradiology Oct 2005, 26 (9) 2371-2377;
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