Article Figures & Data
Figures
- Fig 1.
CTP in a patient with T2N2a carcinoma of the left valeculla before and after one cycle of neoadjuvant chemotherapy.
Axial CT image (A) through the level of the tumor, color maps of BF (B), and BV (C) were acquired before the start of therapy (baseline). Note a large tumor in the valeculla (arrows) before the start of therapy and a metastatic left cervical node (arrowhead). This tumor showed a high level of BF (131.5 mL/100 g/min) and BV (5.12 mL/100 g). Postinduction chemotherapy CT image through the level of the tumor (D), color maps of BF (E) and BV (F) at approximately similar anatomical level are also shown. A marked reduction in tumor size was noted after the chemotherapy (arrows). Also the perfusion maps demonstrate decrease in BF and BV. Quantitatively, there was 96% reduction in BF and 63% reduction in BV. Direct laryngoscopy showed nearly complete resolution of the tumor (patient 2).
- Fig 2.
Graph showing the distribution of percent tumor response as a function of pretreatment BV. The pretherapy BVs ranged between 2.23 and 8.16 mL/100 g and endoscopic tumor response ranged between 0% and 100%.
Tables
- Table 1:
Comparison of percentage change in CT perfusion parameters with endoscopic reduction in tumor volume
Patient No. Primary Site CTP Parameters % Change Endoscopic Tumor Volume Reduction (%) BF BV CP MTT 1 Tongue base −0.8 −54 −6 −48 70 2 Valeculla −96 −69 −64 69 100 3 Tonsil −64 −20 −41 49 50 4 Tonsil −66 24 −28 69 90 5 Tongue base −20 −24 10 18 50 6 Tongue base −43 −8 −3.6 30 0 7 Tongue base 40 37 3.4 −11 20 8 Tongue base −23 −29 −2 15 90 9 Glossotonsillar sulcus −82 −66 −56 72 70 Note:—Negative sign indicates reduction and positive values indicates interval increase in the parameter value on follow-up study. Nonresponders are presented in bold italics.
- Table 2:
Comparison of pretherapy and posttherapy values of BF (ml/100 g/min), BV (ml/100 g), CP (ml/100 g/min), and MTT (s)
Patient No. BF Pretherapy BF Post BV Pretherapy BV Post CP Pretherapy CP Post MTT Pretherapy MTT Post 1 59.72 59.23 8.16 3.75 20.52 19.21 10.85 5.55 2 131.05 4.34 5.12 1.54 22.94 8.11 4.19 13.89 3 97.11 34.27 4.32 3.44 30.44 18.04 4.2 8.23 4 118.15 40.62 3.87 5.07 35.44 25.63 3.52 11.2 5 92.71 73.97 3.4 2.57 19.27 21.44 4.1 3.37 6 55.46 31.76 3.2 2.94 21.93 21.14 5.48 7.93 7 58.4 96.36 2.23 3.54 26.34 26.43 3.12 2.76 8 86.03 66.67 4.5 3.16 24.26 23.77 5.5 6.54 9 214.8 36.56 6.46 2.2 26.62 11.77 2.14 7.81 Note:—Post refers to posttherapy values. Nonresponders are presented in bold italics.
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