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Research ArticleINTERVENTIONAL

Outcome of Acute Vertebrobasilar Occlusions Treated with Intra-Arterial Fibrinolysis in 180 Patients

G. Schulte-Altedorneburg, G.F. Hamann, M. Mull, D. Kühne, M. Liebetrau, W. Weber, H. Brückmann and T.E. Mayer
American Journal of Neuroradiology November 2006, 27 (10) 2042-2047;
G. Schulte-Altedorneburg
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G.F. Hamann
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M. Mull
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D. Kühne
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M. Liebetrau
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W. Weber
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H. Brückmann
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T.E. Mayer
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    Fig. 1.

    Case of a 30-year-old woman comatous for 2 hours upon arrival at the hospital and during the angiography.

    A, The anteroposterior view of the angiogram demonstrates the complete caudal occlusion of the BA. A microcatheter was placed in both VAS, and 140 mg of rtPA was administered.

    B, An interim result showing partial recanalization.

    C, The final result showing complete recanalization of the vertebrobasilar system. The patient was asymptomatic at first but developed a palsy of the right VI and VII cranial nerves 1 day later.

    D, Follow-up MR imaging (T1-weighted, contrast-enhanced) confirms the subacute ischemic infarction in the right PICA territory and at the pontomedullary junction, where the nuclei of the VI and VII cranial nerves are located.

Tables

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    Table 1:

    Relationship between thrombus volume, etiology, site of occlusion, and recanialization

    No Recanalization (%)Partial Recanalization (%)Complete Recanalization (%)n
    Thrombus volume (P < .001)
        <100 μl1098157
        100-300 μl26225281
        >300 μl45292642
    Etiology (not significant)
        Cardioembolism27205299
        Embolism from VA2157419
        Atherothrombotic24235362
    Site of occlusion (not significant)
        Midbasilar & rostral22176193
        Caudal24235362
        Cervical40204025
    • Note:—VA indicates vertebral artery.

    • View popup
    Table 2:

    Relationship between recanalization, etiology, VBO, site of occlusion, and posttreatment score

    Posttreatment Scoresn
    mRS 0-2 (%)mRS 3-4 (%)mRS 5-6 (%)
    Recanalization (P < .001)
        None2128644
        Partial34234335
        Complete29383397
    Etiology (not significant)
        Cardioembolism22304898
        Embolism from VA22393918
        Atherothrombotic25235260
    Pretreatment score (P < .001)
        mRS 37129014
        mRS 428304260
        mRS 5142759102
    • Note:—VBO indicates vertebrobasilar occlusion; mRS, modified Rankin Scale; VA, vertebral artery.

    • View popup
    Table 3:

    Relationship between duration of brain stem symptoms, coma duration, patient age, and posttreatment score

    Posttreatment Scoresn
    mRS 0–2 (%)mRS 3–4 (%)mRS 5–6 (%)
    Duration of brain stem symptoms (P < .020*)
        0–4 hours31284151
        4.5–8 hours22294963
        8.5–12 hours16226232
        >12 hours11335618
    Coma duration (P < .001*)
        0.5–4 hours22245345
        4.5–8 hours10266531
        8.5–12 hours0208010
    Patient’s age (P < .020)
        22–39 years42253324
        40–69 years223147118
        >70 years15216534
    • Note:—*indicates univariable testing; mRS, modified Rankin scale.

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American Journal of Neuroradiology: 27 (10)
American Journal of Neuroradiology
Vol. 27, Issue 10
November 2006
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Cite this article
G. Schulte-Altedorneburg, G.F. Hamann, M. Mull, D. Kühne, M. Liebetrau, W. Weber, H. Brückmann, T.E. Mayer
Outcome of Acute Vertebrobasilar Occlusions Treated with Intra-Arterial Fibrinolysis in 180 Patients
American Journal of Neuroradiology Nov 2006, 27 (10) 2042-2047;

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Outcome of Acute Vertebrobasilar Occlusions Treated with Intra-Arterial Fibrinolysis in 180 Patients
G. Schulte-Altedorneburg, G.F. Hamann, M. Mull, D. Kühne, M. Liebetrau, W. Weber, H. Brückmann, T.E. Mayer
American Journal of Neuroradiology Nov 2006, 27 (10) 2042-2047;
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  • Developing practice recommendations for endovascular revascularization for acute ischemic stroke
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  • Staged Escalation Therapy in Acute Basilar Artery Occlusion: Intravenous Thrombolysis and On-Demand Consecutive Endovascular Mechanical Thrombectomy: Preliminary Experience in 16 Patients
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