Article Figures & Data
Figures
- Fig 1.
Melanoma brain metastases were detected principally on T2*-weighted sequences in 7% of 120 lesions. T1 isointense, nonenhancing lesions are seen in the right cerebellar hemisphere lesion (top row) and left frontal lobe (bottom row). A subtle abnormality can be seen on the FLAIR image (G), but the lesion is markedly more conspicuous on T2*-weighted image (H). T1-weighted sequences before (A, E) and after (B, F) administration of gadolinium, FLAIR sequences (C, G), and T2*-weighted sequences (D, H) are shown.
- Fig 2.
Combined susceptibility effect and T1-weighted hyperintensity were seen in only one quarter of lesions, but this combination was 16 times more likely with melanoma than with lung cancer metastases. Intrinsic T1-weighted hyperintensity (A), minimal enhancement (B), minimal surrounding edema on a FLAIR image (C), and susceptibility effect (D) are shown in metastatic melanoma in the right frontal lobe.
Tables
Melanoma Lung Patients 31 23 Average age (y) 59.6 (SD 14.0) 62.5 (SD 10.2) (P = .40) Sex (M:F) 23:8 9:14 (P < .01) Systemic metastasis* 94% (29/31) 35% (8/23) (P < .01) Primary Skin 27 Ocular 1 Unknown 3 NSCLC 20 SCLC 3 Notes:—NSCLC indicated non-small cell lung carcioma; SCLC, small cell lung carcioma.
* Present at time of brain metastasis diagosis.
Melanoma Lung Total lesions examined 120 120 Average lesions per patient 3.9 5.2 (P = .36) Single lesion 12 patients 7 patients Average diameter (mm) 9 8 (P = .18) Supratentorial 106 98 (P = .25) Melanoma Lung Total lesion number 120 120 Susceptibility effect 42% (50/120) 8% (10/120) (P < .01) Amelanotic/slightly 49% (17/35)* Heavily melanotic 33% (10/30)† (P = .4) Hyperintense T1WI 55% (66/120) 12% (15/120) (P < .01) Amelanotic/slightly 49% (17/35) Heavily melanotic 83% (25/30) (P < .01) Enhancement 78% (94/120) 98% (118/120) (P = .02) Edema 68% (82/120) 66% (80/120) (P = .56) * Total of 35 lesions in 20 patients with biopsy material.
† Total of 30 lesions in 20 patients with biopsy material.
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