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Research ArticleNeurointervention

Protective Effect of Agmatine on a Reperfusion Model After Transient Cerebral Ischemia: Temporal Evolution on Perfusion MR Imaging and Histopathologic Findings

D.J. Kim, D.I. Kim, S.K. Lee, S.H. Suh, Y.J. Lee, J. Kim, T.S. Chung and J.E. Lee
American Journal of Neuroradiology April 2006, 27 (4) 780-785;
D.J. Kim
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D.I. Kim
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S.K. Lee
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S.H. Suh
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Y.J. Lee
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J. Kim
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T.S. Chung
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J.E. Lee
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    Fig 1.

    Agmatine-treated cat with type I and II reperfusion.

    A, Persistent hyperperfusion is noted in the left frontal lobe (type I reperfusion, arrow). Initial hyperemia in the left striatum shows hypoperfusion on the last follow-up image (type II reperfusion, arrowhead). Notice the lack of signal-intensity changes on T2-weighted (T2WI) or diffusion-weighted images (DWI.). (B) A few red-stained TUNEL-positive cells are seen in all regions of the left hemisphere. ADC indicates apparent diffusion coefficient.

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  • Incidence of reperfusion types in the respective brain regions

    SFIFSTITStriatumTotal (n=125)
    I9 (5/4)12 (6/6)10 (4/6)14 (4/10)9 (4/5)54 (23/31)
    II2 (0/2)4 (1/3)6 (4/2)2 (1/1)4 (1/3)18 (7/11)
    III3 (0/3)1 (0/1)4 (1/3)5 (3/2)9 (4/5)22 (8/14)
    N11 (5/6)8 (3/5)5 (1/4)4 (2/2)3 (1/2)31 (12/19)
    • Note:—SF indicates superior frontal lobe; IF, inferior frontal lobe; ST, superior temporal lobe; IT, inferior temporal lobe; I, initial reperfusion hyperemia with late continuous hyperperfusion or late normal perfusion; II, initial reperfusion hyperemia and gradual depletion of rCBV; III, persistent hypoperfusion; N, normal perfusion. Numbers in parentheses are related as follows: (Control ischemia group/agmatine-treated group).

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American Journal of Neuroradiology: 27 (4)
American Journal of Neuroradiology
Vol. 27, Issue 4
April 2006
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D.J. Kim, D.I. Kim, S.K. Lee, S.H. Suh, Y.J. Lee, J. Kim, T.S. Chung, J.E. Lee
Protective Effect of Agmatine on a Reperfusion Model After Transient Cerebral Ischemia: Temporal Evolution on Perfusion MR Imaging and Histopathologic Findings
American Journal of Neuroradiology Apr 2006, 27 (4) 780-785;

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Protective Effect of Agmatine on a Reperfusion Model After Transient Cerebral Ischemia: Temporal Evolution on Perfusion MR Imaging and Histopathologic Findings
D.J. Kim, D.I. Kim, S.K. Lee, S.H. Suh, Y.J. Lee, J. Kim, T.S. Chung, J.E. Lee
American Journal of Neuroradiology Apr 2006, 27 (4) 780-785;
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