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Research ArticlePEDIATRICS

How Depth of Anesthesia Influences the Blood Oxygenation Level–Dependent Signal from the Visual Cortex of Children

V.L. Marcar, U. Schwarz, E. Martin and T. Loenneker
American Journal of Neuroradiology April 2006, 27 (4) 799-805;
V.L. Marcar
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U. Schwarz
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E. Martin
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T. Loenneker
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    Fig 1.

    The figure shows the cortical site of the positive BOLD response (red) and the negative BOLD response (blue) in a single child at the 3 levels of sevoflurane anesthesia. The extent of activation of the positive BOLD response is clearly largest, at 0.75 MAC. The extent of activation of the negative BOLD response can be seen to decline with increasing sevoflurane level.

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    Fig 2.

    A, The mean number of activated voxels with a positive BOLD response. B, The mean number of activated voxels with a negative BOLD response at the 3 levels of sevoflurane anesthesia. C, The mean, peak ΔR2* from the positive BOLD. D, The mean, peak ΔR2* from the negative BOLD response at the 3 levels of sevoflurane anesthesia. The error bars indicate the standard error of the mean.

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    Fig 3.

    The 2 panels show the frequency distribution of the peak ΔR2* at the 3 levels of sevoflurane anesthesia. Left, the frequency distribution for the positive BOLD response. Right, the frequency distribution of the negative BOLD response. We selected to show the absolute values for each bin, rather than the relative values, to convey to the reader the difference in the number of activated voxels upon which the distribution is based.

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American Journal of Neuroradiology: 27 (4)
American Journal of Neuroradiology
Vol. 27, Issue 4
April 2006
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V.L. Marcar, U. Schwarz, E. Martin, T. Loenneker
How Depth of Anesthesia Influences the Blood Oxygenation Level–Dependent Signal from the Visual Cortex of Children
American Journal of Neuroradiology Apr 2006, 27 (4) 799-805;

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How Depth of Anesthesia Influences the Blood Oxygenation Level–Dependent Signal from the Visual Cortex of Children
V.L. Marcar, U. Schwarz, E. Martin, T. Loenneker
American Journal of Neuroradiology Apr 2006, 27 (4) 799-805;
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