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Research ArticleBRAIN

Quantitative Analysis of the Effects of Physiologic Brain Motion on Point-Resolved Spectroscopy

P.M. Pattany, M.G. Massand, B.C. Bowen and R.M. Quencer
American Journal of Neuroradiology May 2006, 27 (5) 1070-1073;
P.M. Pattany
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M.G. Massand
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B.C. Bowen
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R.M. Quencer
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    Fig 1.

    Schematic representation of the PRESS sequence used to acquire spectral data. The unshaded gradients pulsed are applied in the x, y, and z axes for voxel selection. The shaded gradient pulses are dephase-rephase gradients, which remove the spurious signal intensity generated by RF inhomogeneities. The 90° and 180° RF pulses are indicated. The time window for data sampling is also indicated.

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    Fig 2.

    T2-weighted axial image demonstrating voxel placement in the region of the left basal ganglia.

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    Fig 3.

    Global phase difference for PRESS (solid line) as a function of gating delay from the R wave. Note that the global phase change of the water signal intensity is minimal throughout the cardiac cycle. The STEAM (dashed line) data are from previously published work.9

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    Fig 4.

    PRESS spectra obtained from one subject, illustrating the spectral quality of gated (A) and nongated (B) acquisitions. This figure demonstrates that there is no difference in spectral quality between the 2 methods.

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  • Peak area measurements for individual metabolites, from gated and nongated point-resolved spectroscopy acquisitions

    MetabolitePeak Area (au)P-value
    GatedNongated
    NAA1225.9 ± 121.51152.8 ± 85.5.137
    Cr967.3 ± 107.01007.5 ± 89.6.375
    Cho754.0 ± 60.8752.0 ± 107.1.959
    • Note:—NAA indicates N-acetylaspartate; Cr, total creatine; Cho, choline-containing compounds. For comparisons between gated and nongated acquisitions, P > .05 is nonsignificant. Arbitrary units, as defined in Methods.

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American Journal of Neuroradiology: 27 (5)
American Journal of Neuroradiology
Vol. 27, Issue 5
May 2006
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Cite this article
P.M. Pattany, M.G. Massand, B.C. Bowen, R.M. Quencer
Quantitative Analysis of the Effects of Physiologic Brain Motion on Point-Resolved Spectroscopy
American Journal of Neuroradiology May 2006, 27 (5) 1070-1073;

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Quantitative Analysis of the Effects of Physiologic Brain Motion on Point-Resolved Spectroscopy
P.M. Pattany, M.G. Massand, B.C. Bowen, R.M. Quencer
American Journal of Neuroradiology May 2006, 27 (5) 1070-1073;
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