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Research ArticleHead and Neck Imaging

Magnetic Resonance Imaging for the Detection of Nasopharyngeal Carcinoma

A.D. King, A.C. Vlantis, R.K.Y. Tsang, T.M.K. Gary, A.K.Y. Au, C.Y. Chan, S.Y. Kok, W.T. Kwok, H.K. Lui and A.T. Ahuja
American Journal of Neuroradiology June 2006, 27 (6) 1288-1291;
A.D. King
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A.C. Vlantis
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R.K.Y. Tsang
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T.M.K. Gary
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A.K.Y. Au
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C.Y. Chan
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S.Y. Kok
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W.T. Kwok
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H.K. Lui
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A.T. Ahuja
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    Fig 1.

    Axial T1-weighted MR image postcontrast of the nasopharynx of a patient with proved NPC (group 1) undergoing staging with a small cancer confined to the left side of the nasopharynx (arrows) (stage T1).

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    Fig 2.

    Axial T1-weighted contrast-enhanced MR image of a patient with suspected NPC (group 2) with a normal nasopharynx (arrows show normal enhancing mucosa).

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    Fig 3.

    Axial T1-weighted contrast-enhanced MR image of the nasopharynx in 2 patients with suspected NPC (group 2) where cancer was initially missed by endoscopy and biopsy but identified by MR imaging. Patient with a small cancer in the left fossa of Rosenmuller (arrows) (stage T1) (A) and patient with a small cancer over the torus tubarius (arrows) (stage T1) (B).

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    Fig 4.

    Axial T1-weighted contrast-enhanced MR image of the nasopharynx in a patient with suspected NPC (group 2) where MR imaging incorrectly diagnosed cancer that was later shown by biopsy to be lymphoid hyperplasia. A, Section at the level of the fossa of Rosenmuller shows mucosal abnormality in the fossa bilaterally (arrows), giving the false-positive result on MR imaging for cancer.

    B, Section at the level of the roof shows the “striped” appearance of normal lymphoid tissue in the adenoids (arrows).

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    Table 1:

    T-stages as established by American Joint Committee on Cancer

    Stage of Primary TumorExtent of Tumor
    T1Tumor confined to the nasopharynx
    T2aTumor extends to the oropharynx and/or nasal fossa without parapharyngeal extension
    T2bTumor extends to the oropharynx and/or nasal fossa with parapharyngeal extension
    T3Tumor invades bony structures and/or paranasal sinuses
    T4Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, or orbit
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    Table 2:

    MRI scoring system and MRI results for 77 patients with suspected NPC (group 2)

    ScoreMRI FindingsNo. of Patients% of Patients
    1Normal nasopharynx4660
    2Normal nasopharynx with lymphoid tissue in the adenoids1519
    3Mild diffuse mucosal thickening with the signal intensity of mucosa912
    4Focal mucosal thickening with the signal intensity of NPC23
    5Definite NPC56
    • Note:—NPC indicates nasopharyngeal carcinoma.

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    Table 3:

    T-stage of 456 patients with proved nasopharyngeal carcinoma (group 1)

    T-stageNo. of Patients% of Patients
    T111826
    T26514
    T316336
    T411024
    T1–T4456100
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    Table 4:

    Results of MRI in 77 patients with suspected NPC (group 2)

    Biopsy Positive for NPCBiopsy Negative for NPC
    MRI positive for NPC34
    MRI negative for NPC070
    • Note:—NPC indicates nasopharyngeal carcinoma.

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American Journal of Neuroradiology: 27 (6)
American Journal of Neuroradiology
Vol. 27, Issue 6
June 2006
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Cite this article
A.D. King, A.C. Vlantis, R.K.Y. Tsang, T.M.K. Gary, A.K.Y. Au, C.Y. Chan, S.Y. Kok, W.T. Kwok, H.K. Lui, A.T. Ahuja
Magnetic Resonance Imaging for the Detection of Nasopharyngeal Carcinoma
American Journal of Neuroradiology Jun 2006, 27 (6) 1288-1291;

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Magnetic Resonance Imaging for the Detection of Nasopharyngeal Carcinoma
A.D. King, A.C. Vlantis, R.K.Y. Tsang, T.M.K. Gary, A.K.Y. Au, C.Y. Chan, S.Y. Kok, W.T. Kwok, H.K. Lui, A.T. Ahuja
American Journal of Neuroradiology Jun 2006, 27 (6) 1288-1291;
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