[¹¹C]Methionine PET, Histopathology, and Survival in Primary Brain Tumors and Recurrence

[¹¹C]Methionine maximum uptake index as a function of grading. Grading values are regrouped as indicated in the text. Grade 0′ (benign) and grade I′ (WHO grade I and intermediate grade I–II) show significantly reduced uptake compared with grade II′–IV′ lesions. Box plots show the mean value, and whiskers show the 95% confidence interval limits. Boxes show 1 SE; whiskers show the 95% confidence interval limits.

Example of [¹¹C]methionine PET of a patient with a grade I–II tumor (woman, 31 years old, oligodendroglioma in follow-up) (A) and a patient with a grade IV tumor (woman, 33 years old, glioblastoma multiforme in follow-up), showing comparable tracer uptake (B).