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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSPINE

Pain Response in the First Trimester after Percutaneous Vertebroplasty in Patients with Osteoporotic Vertebral Compression Fractures with or without Bone Marrow Edema

M.H.J. Voormolen, W.J. van Rooij, M. Sluzewski, Y. van der Graaf, L.E.H. Lampmann, P.N.M. Lohle and J.R. Juttmann
American Journal of Neuroradiology August 2006, 27 (7) 1579-1585;
M.H.J. Voormolen
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W.J. van Rooij
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M. Sluzewski
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Y. van der Graaf
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L.E.H. Lampmann
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P.N.M. Lohle
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J.R. Juttmann
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    Fig 1.

    Lateral STIR and T1-weighted MR images of various osteoporotic vertebral compression fractures with absent, partial, and full bone marrow edema (BME) before percutaneous vertebroplasty (PV) and lateral radiographic images after PV.

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    Fig 2.

    Osteoporotic vertebral compression fracture of L2 with absent bone marrow edema (BME) treated by percutaneous vertebroplasty (PV). Lateral STIR and T1-weighted MR images of the lumbar spine before and after PV. In the middle, lateral and anteroposterior radiographic images after PV.

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    Fig 3.

    Osteoporotic vertebral compression fractures of L1 and L3 with partial bone marrow edema (BME) treated by percutaneous vertebroplasty (PV). Lateral STIR and T1-weighted MR images of the lumbar spine before and after PV. In the middle are lateral and anteroposterior radiographic images after PV.

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    Fig 4.

    Osteoporotic vertebral compression fracture of L1 with full bone marrow edema (BME) treated by percutaneous vertebroplasty (PV). Lateral STIR and T1-weighted MR images of the lumbar spine before and after PV. In the middle, lateral and anteroposterior radiographic images after PV.

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    Fig 5.

    Visual analog score (VAS) for pain both preprocedure (0 months) and at follow-up periods after percutaneous vertebroplasty (PV) in patients with absent bone marrow edema (no BME) in treated vertebral compression fractures and patients with full BME in treated VCF.

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    Fig 6.

    Analgesic use both before percutaneous vertebroplasty (PV) (0 months) and at follow-up periods after PV in patients with absent bone marrow edema (no BME) in treated vertebral compression fractures (VCF) and patients with full BME in treated VCF. NSAID indicates nonsteroidal anti-inflammatory drug.

Tables

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    Table 1:

    Characteristics of patients with absent bone marrow edema (no BME) in treated osteoporotic vertebral compression fractures (VCF) (group I) and patients with full BME (full BME) in treated VCF (group II) prior to percutaneous vertebroplasty (PV)

    Group I, No BMEGroup II, Full BMEP value
    Total no. of study patients1431
    Mean age, y (range)71 (47–88)75 (51–88).5
        Median6970
    Women (%)12 (86)27 (87).9
    No. of VCF treated by PV2238.01
    Patients with multiple treated VCF (%)7 (50)7 (23).1
    Mean age treated VCF, (no) (range)8.3 (3–36)4.7 (2–24).07
        Median5.53.0
    Extent bone marrow edema in treated VCF
        Absent (0%)22
        Full (100%)38
    Shape of treated VCF
        Wedge (%)17 (77)28 (74).7
        Biconcave (%)5 (23)9 (24)
        Crush (%)1 (2)
    Grade of treated VCF
        Mild (%)14 (64)8 (21)<.01
        Moderate (%)8 (36)14 (37)
        Severe (%)16 (42)
    Mean injected cement volume, mm3 (range)3.5 (1.2–5.5)2.7 (1.0–4.5)<.01
        Median4.02.5
    Mean initial VAS (range)8.6 (7–10)8.6 (6–10).9
        Median8.09.0
    Initial analgesic use
        No (%)140.2
        Paracetamol (%)1416
        NSAID (%)2929
        Opiate derivative (%)4355
    • Note:—VAS indicates visual analogue score; NSAID, nonsteroidal anti-inflammatory drug.

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    Table 2:

    Decrease in mean visual analogue score (VAS) for pain and analgesics used at 1 and 3 months after percutaneous vertebroplasty (PV) in patients with vertebral compression fractures (VCF) with absent bone marrow edema (no BME) prior to PV and patients with full BME (full BME) in treated VCF

    Follow-up Period after PV
    1 Month3 Months
    Mean Decrease VASMean Decrease AnalgesicsMean Decrease VASMean Decrease Analgesics
    No BME5.143%0.40%
    Full BME5.884%0.513%
    Regression coefficient.7.9.09.07
    99% Confidence interval−1–2.40.1–1.7−0.7–0.9−0.4–0.5
    • View popup
    Table 3:

    Pain response at both follow-up intervals after percutaneous vertebroplasty (PV) in patients without bone marrow edema (BME) in treated vertebral compression fractures (VCF) prior to PV and patients with severe BME in treated VCF prior to PV

    Follow-up Period after PV
    1 Month3 Months
    No BMESevere BMEP ValueNo BMESevere BMEP Value
    Pain unchanged at treated level(s)4 (29%)2 (6%).044 (29%)1 (3%).01
    Pain decrease at treated level(s)10 (71%)29 (94%).0410 (71%)30 (97%).01
    Back pain decrease in general9 (64%)27 (87%).089 (64%)23 (74%).4
    Pain at untreated other level with no diagnostic substrate1 (7%)2 (6%).91 (7%)6 (19%).3
    Symptomatic new VCF01 (3%).5
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American Journal of Neuroradiology: 27 (7)
American Journal of Neuroradiology
Vol. 27, Issue 7
August 2006
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Cite this article
M.H.J. Voormolen, W.J. van Rooij, M. Sluzewski, Y. van der Graaf, L.E.H. Lampmann, P.N.M. Lohle, J.R. Juttmann
Pain Response in the First Trimester after Percutaneous Vertebroplasty in Patients with Osteoporotic Vertebral Compression Fractures with or without Bone Marrow Edema
American Journal of Neuroradiology Aug 2006, 27 (7) 1579-1585;

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Pain Response in the First Trimester after Percutaneous Vertebroplasty in Patients with Osteoporotic Vertebral Compression Fractures with or without Bone Marrow Edema
M.H.J. Voormolen, W.J. van Rooij, M. Sluzewski, Y. van der Graaf, L.E.H. Lampmann, P.N.M. Lohle, J.R. Juttmann
American Journal of Neuroradiology Aug 2006, 27 (7) 1579-1585;
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