Research ArticleBrain
Normal-Appearing White Matter Changes Vary with Distance to Lesions in Multiple Sclerosis
H. Vrenken, J.J.G. Geurts, D.L. Knol, C.H. Polman, J.A. Castelijns, P.J.W. Pouwels and F. Barkhof
American Journal of Neuroradiology October 2006, 27 (9) 2005-2011;
H. Vrenken
J.J.G. Geurts
D.L. Knol
C.H. Polman
J.A. Castelijns
P.J.W. Pouwels

References
- ↵Vaithianathar L, Tench CR, Morgan PS, et al. White matter T(1) relaxation time histograms and cerebral atrophy in multiple sclerosis. J Neurol Sci 2002;197:45–50
- ↵van Walderveen MA, van Schijndel RA, Pouwels PJ, et al. Multislice T1 relaxation time measurements in the brain using IR-EPI: reproducibility, normal values, and histogram analysis in patients with multiple sclerosis. J Magn Reson Imaging 2003;18:656–64
- ↵Griffin CM, Chard DT, Parker GJ, et al. The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis. J Neurol 2002;249:193–99
- ↵Stevenson VL, Parker GJ, Barker GJ, et al. Variations in T1 and T2 relaxation times of normal appearing white matter and lesions in multiple sclerosis. J Neurol Sci 2000;178:81–87
- ↵Schmierer K, Scaravilli F, Altmann DR, et al. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol 2004;56:407–15
- ↵Filippi M, Campi A, Dousset V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995;45:478–82
- ↵Loevner LA, Grossman RI, Cohen JA, et al. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. Radiology 1995;196:511–15
- ↵Catalaa I, Grossman RI, Kolson DL, et al. Multiple sclerosis: magnetization transfer histogram analysis of segmented normal-appearing white matter. Radiology 2000;216:351–55
- Cercignani M, Bozzali M, Iannucci G, et al. Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:311–17
- Dehmeshki J, Chard DT, Leary SM, et al. The normal appearing grey matter in primary progressive multiple sclerosis: a magnetisation transfer imaging study. J Neurol 2003;250:67–74
- ↵Ge Y, Grossman RI, Udupa JK, et al. Magnetization transfer ratio histogram analysis of normal-appearing gray matter and normal-appearing white matter in multiple sclerosis. J Comput Assist Tomogr 2002;26:62–68
- ↵van Waesberghe JH, Kamphorst W, De Groot CJ, et al. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability. Ann Neurol 1999;46:747–54
- ↵Parry A, Clare S, Jenkinson M, et al. White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis. J Neurol 2002;249:1279–86
- Santos AC, Narayanan S, de Stefano N, et al. Magnetization transfer can predict clinical evolution in patients with multiple sclerosis. J Neurol 2002;249:662–68
- ↵van Buchem MA, Grossman RI, Armstrong C, et al. Correlation of volumetric magnetization transfer imaging with clinical data in MS. Neurology 1998;50:1609–17
- ↵Mainero C, de Stefano N, Iannucci G, et al. Correlates of MS disability assessed in vivo using aggregates of MR quantities. Neurology 2001;56:1331–34
- ↵Iannucci G, Rovaris M, Giacomotti L, et al. Correlation of multiple sclerosis measures derived from T2-weighted, T1-weighted, magnetization transfer, and diffusion tensor MR imaging. AJNR Am J Neuroradiol 2001;22:1462–67
- ↵Phillips MD, Grossman RI, Miki Y, et al. Comparison of T2 lesion volume and magnetization transfer ratio histogram analysis and of atrophy and measures of lesion burden in patients with multiple sclerosis. AJNR Am J Neuroradiol 1998;19:1055–60
- ↵Miller DH, Thompson AJ, Filippi M. Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis. J Neurol 2003;250:1407–19
- ↵Castriota-Scanderbeg A, Fasano F, Filippi M, et al. T1 relaxation maps allow differentiation between pathologic tissue subsets in relapsing-remitting and secondary progressive multiple sclerosis. Mult Scler 2004;10:556–61
- ↵Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227–31
- ↵Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444–52
- ↵Cutter GR, Baier ML, Rudick RA, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999;122:871–82
- ↵Venkatesan R, Lin W, Haacke EM. Accurate determination of spin-density and T1 in the presence of RF-field inhomogeneities and flip-angle miscalibration. Magn Reson Med 1998;40:592–602
- ↵Jenkinson M, Bannister P, Brady M, et al. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41
- ↵Ropele S, Filippi M, Valsasina P, et al. Assessment and correction of B1-induced errors in magnetization transfer ratio measurements. Magn Reson Med 2005;53:134–40
- ↵Smith SM. Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–55
- ↵Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57
- ↵Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002;17:479–89
- ↵Allen IV, McQuaid S, Mirakhur M, et al. Pathological abnormalities in the normal-appearing white matter in multiple sclerosis. Neurol Sci 2001;22:141–44
- ↵Bot JC, Blezer EL, Kamphorst W, et al. The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results. Radiology 2004;233:531–40
- ↵Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278–85
- ↵Kornek B, Storch MK, Weissert R, et al. Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 2000;157:267–76
- ↵Evangelou N, Esiri MM, Smith S, et al. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann Neurol 2000;47:391–95
- ↵Helms G, Stawiarz L, Kivisakk P, et al. Regression analysis of metabolite concentrations estimated from localized proton MR spectra of active and chronic multiple sclerosis lesions. Magn Reson Med 2000;43:102–10
- ↵Vrenken H, Barkhof F, Uitdehaag BM, et al. MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter. Magn Reson Med 2005;53:256–66
- ↵Armstrong CL, Traipe E, Hunter JV, et al. Age-related, regional, hemispheric, and medial-lateral differences in myelin integrity in vivo in the normal adult brain. AJNR Am J Neuroradiol 2004;25:977–84
- ↵Mehta RC, Pike GB, Enzmann DR. Magnetization transfer MR of the normal adult brain. AJNR Am J Neuroradiol 1995;16:2085–91
- ↵Griffin CM, Parker GJ, Barker GJ, et al. MTR and T1 provide complementary information in MS NAWM, but not in lesions. Mult Scler 2000;6:327–31
- ↵Allen IV, McKeown SR. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 1979;41:81–91
- ↵Vos CM, Geurts JJ, Montagne L, et al. Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis 2005;20:953–60. Epub 2005 Jul 21
- ↵Laule C, Vavasour IM, Moore GR, et al. Water content and myelin water fraction in multiple sclerosis. A T2 relaxation study. J Neurol 2004;251:284–93
- ↵Lucchinetti C, Bruck W, Parisi J, et al. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 2000;47:707–17
- ↵van der Valk P, De Groot CJ. Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS. Neuropathol Appl Neurobiol 2000;26:2–10
In this issue
Advertisement
H. Vrenken, J.J.G. Geurts, D.L. Knol, C.H. Polman, J.A. Castelijns, P.J.W. Pouwels, F. Barkhof
Normal-Appearing White Matter Changes Vary with Distance to Lesions in Multiple Sclerosis
American Journal of Neuroradiology Oct 2006, 27 (9) 2005-2011;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement