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Research ArticleSpine Imaging and Spine Image-Guided Interventions

Which MR Imaging Sequences Are Necessary in Determining the Need for Radiation Therapy for Cord Compression? A Prospective Study

A.J. Johnson, J. Ying, T. El Gammal, R.D. Timmerman, R.Y. Kim and B. Littenberg
American Journal of Neuroradiology January 2007, 28 (1) 32-37;
A.J. Johnson
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J. Ying
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T. El Gammal
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R.D. Timmerman
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R.Y. Kim
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B. Littenberg
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Article Figures & Data

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  • Fig 1.
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    Fig 1.

    Scatterplots show the positive linear relationships between median spinal level (ML) and total number of spinal levels (NL) of radiation therapy planned by using reference MR imaging protocol 4 compared with the more limited MR imaging protocols 1, 2, and 3. The Pearson correlation coefficient, r, and intraclass correlation (ICC) are both indicated for each comparison.

Tables

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    Table 1:

    Subjects

    Patient No./Age (y)/SexPrimary NeoplasmOther Metastatic Disease
    1/58/FBreastNo
    2/52/FChronic myelogenous leukemiaNo (after stem cell transplant)
    3/76/FBreastNo
    4/70/FLungBrain
    5/62/MColonLiver, omentum
    6/75/MMelanomaNo
    7/70/FMerkel cell, lipLiver
    8/56/MNon-Hodgkin lymphomaBrain, cranial nerve
    9/65/FMultiple myeloma
    10/59/FBreastAxillary nodes
    11/60/FBreastLiver, brain
    12/31/FBreastBrain
    13/28/FBreastNo
    14/49/FBreastLung, brachial plexus
    15/65/MMelanomaLiver, neck
    16/42/MMelanomaQuestionable adrenal
    17/71/MProstateNo
    18/69/FLungBrain
    19/62/MPancreasLiver, rib
    20/33/MNon-Hodgkin lymphomaCranial nerves
    21/50/FBreastNo
    22/52/MFloor of mouthNo
    23/54/FBreastNo
    24/64/MLungMediastinum
    25/56/MMultiple myeloma
    26/85/MProstateLiver, retroperitoneum
    27/68/FLungBrain
    28/46/FNon-Hodgkin lymphomaKidney
    29/71/MMultiple myeloma
    30/80/FLungBrain
    31/64/MUreterMediastinum
    • View popup
    Table 2:

    Association of radiation therapy being planned with other factors (logistic regression model)

    FactorP Value*
    MRI protocol type0.873
    Neuroradiologist0.761
    MRI protocol type × neuroradiologist0.724
    • * Note:—* indicates that P values are from the logistic regression model.

    • View popup
    Table 3:

    Comparing frequencies of radiation therapy planned among MRI protocol types (logistic regression model)

    MRI ProtocolFrequency % (SE)
    145 (7)
    246 (6)
    349 (7)
    449 (7)
    • View popup
    Table 4:

    Agreement in plan for radiation therapy between the reference MRI protocol type and the other MRI protocols

    MRI Protocol Typesκ (SE)
    1 vs 40.76 (0.05)
    2 vs 40.73 (0.05)
    3 vs 40.76 (0.05)
    • View popup
    Table 5:

    Significance of factor effects on radiation therapy recommendations

    EffectMLNL
    MRI protocol type0.7800.686
    Neuroradiologist0.1260.877
    MRI protocol type × neuroradiologist0.5250.992
    • Note:—ML indicates median spinal level; NL, total number of spinal levels.

    • Values are P values are from mixed models.

    • View popup
    Table 6:

    Summary of median levels (ML) and total number of levels (NL) of recommended spinal radiation by MRI protocol type

    MRI Protocol TypeMLNL
    117.10 (0.97)7.63 (1.05)
    217.18 (0.96)8.71 (1.02)
    317.58 (0.97)8.75 (1.04)
    417.04 (0.96)8.74 (1.00)
    • Note:—Values are presented as mean (SE). Differences in means of ML and NL were not statistically significant at pairwise comparisons of any 2 protocol types.

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American Journal of Neuroradiology: 28 (1)
American Journal of Neuroradiology
Vol. 28, Issue 1
January 2007
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Cite this article
A.J. Johnson, J. Ying, T. El Gammal, R.D. Timmerman, R.Y. Kim, B. Littenberg
Which MR Imaging Sequences Are Necessary in Determining the Need for Radiation Therapy for Cord Compression? A Prospective Study
American Journal of Neuroradiology Jan 2007, 28 (1) 32-37;

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Which MR Imaging Sequences Are Necessary in Determining the Need for Radiation Therapy for Cord Compression? A Prospective Study
A.J. Johnson, J. Ying, T. El Gammal, R.D. Timmerman, R.Y. Kim, B. Littenberg
American Journal of Neuroradiology Jan 2007, 28 (1) 32-37;
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