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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Patients with Osteoporosis on Steroid Medication Tend to Sustain Subsequent Fractures

A. Hiwatashi and P.L. Westesson
American Journal of Neuroradiology June 2007, 28 (6) 1055-1057; DOI: https://doi.org/10.3174/ajnr.A0519
A. Hiwatashi
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P.L. Westesson
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    Fig 1.

    MR images of vertebrae in a 58-year-old woman with a history of long-term steroid use for treatment of a brain tumor. The patient was treated with multiple sessions of vertebroplasty.

    A, Initial sagittal T1-weighted image 16 days before treatment shows an acute compression fracture of the L3 vertebral body.

    B, Sagittal T1-weighted image 7 days after the initial treatment shows a new compression fracture of the L2 vertebral body. Bone cement is noted in the L3 vertebral body (arrow).

    C, Sagittal T1-weighted image 22 days after the second treatment shows a new compression fracture of the L1 vertebral body. Bone cement is noted in the L3 and L2 vertebral bodies (arrows).

    D, Sagittal T1-weighted image 27 days after the third treatment shows a new compression fracture of the T11 vertebral body. Bone cement is noted in the L3, L2, and L1 vertebral bodies (arrows).

    E, Sagittal T1-weighted image 11 days after the fourth treatment shows a new compression fracture of the T10 vertebral body. Bone cement is noted in the L3, L2, L1, and T11 vertebral bodies (arrows).

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    Table 1:

    Locations and numbers of treated and untreated vertebral compression fractures

    LocationTreatedUntreated
    T201
    T300
    T411
    T523
    T641
    T756
    T855
    T926
    T1081
    T1187
    T1266
    L1176
    L284
    L356
    L463
    L520
    Total7956
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    Table 2:

    Relationship between use of steroid medication and presence of subsequent fractures (no. of patients)

    Steroid UseNo Steroid UseTotal
    Fractures11920
    No fractures53035
    Total163955
    • View popup
    Table 3:

    Association between variables and refracture (logistic regression analysis)

    VariableRegression CoefficientSEWald Statistic95% CI
    Steroid1.7960.7915.1511.278–28.421
    Treatment for osteoporosis−0.7090.7011.0240.125–1.943
    Age−0.2800.0340.6650.909–1.040
    Male sex0.1750.7350.0570.282–5.032
    • Note:—CI indicates confidence interval.

    • View popup
    Table 4:

    Relationship between use of steroid medication and location of subsequent fractures (no. of patients)

    LocationSteroid UseNo Steroid UseTotal
    Adjacent vertebrae61016
    Remote vertebrae10212
    Total161228
    • Note:—Remote vertebrae indicate the fractured vertebrae that had at least 1 nonfractured vertebra between the treated vertebrae.

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American Journal of Neuroradiology: 28 (6)
American Journal of Neuroradiology
Vol. 28, Issue 6
June 2007
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Cite this article
A. Hiwatashi, P.L. Westesson
Patients with Osteoporosis on Steroid Medication Tend to Sustain Subsequent Fractures
American Journal of Neuroradiology Jun 2007, 28 (6) 1055-1057; DOI: 10.3174/ajnr.A0519

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Patients with Osteoporosis on Steroid Medication Tend to Sustain Subsequent Fractures
A. Hiwatashi, P.L. Westesson
American Journal of Neuroradiology Jun 2007, 28 (6) 1055-1057; DOI: 10.3174/ajnr.A0519
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  • Teriparatide and Raloxifene Reduce the Risk of New Adjacent Vertebral Fractures in Postmenopausal Women with Osteoporosis: Results from Two Randomized Controlled Trials
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