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Research ArticlePEDIATRICS

Myelination as Assessed by Conventional MR Imaging is Normal in Young Children with Idiopathic Developmental Delay

S.M. Maricich, P. Azizi, J.Y. Jones, M.C. Morriss, J.V. Hunter, E.O. Smith and G. Miller
American Journal of Neuroradiology September 2007, 28 (8) 1602-1605; DOI: https://doi.org/10.3174/ajnr.A0602
S.M. Maricich
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P. Azizi
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J.Y. Jones
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M.C. Morriss
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J.V. Hunter
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E.O. Smith
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G. Miller
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Tables

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    Table 1:

    Myelination scoring system of Parazzini et al*

    Frontal LobeTemporal LobeParietal LobePeritrigonal Area
    GradePrerolandicPolarConvolution I-IILateralPolarPostrolandicGyriPosteriorSuperior
    0−−−−−−−−−
    1+−−+−+−+−
    2++−++++++
    3+++
    • * The scoring system is binary (0, not myelinated; 1, myelinated).

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    Table 2:

    Control vs IDD comparisons by region*

    Brain RegionControl vs IDD Mann-WhitneyControl vs IDD t testUnivariate Age AnalysisDQ LanguageDQ Language Age ControlDQ MotorDQ Motor Age Control
    Frontal0.7140.8010.8470.7880.9010.5620.949
    Temporal0.7960.7780.4770.3160.1850.0560.095
    Parietal0.7880.7850.9560.8520.9800.5090.869
    Peritrigonal0.8460.7500.8830.0860.0590.1970.295
    FUF0.9400.9420.2550.3170.3150.5750.187
    TUF0.8670.8500.8580.8460.7460.5320.751
    PUF0.7310.7390.9920.7440.8410.2760.481
    • Note:—IDD indicates idiopathic developmental delay; DQ, developmental quotient; FUF, frontal U-fibers; PUF, parietal U-fibers; TUF, temporal U-fibers.

    • * Numbers in the table are P values corresponding to the indicated tests comparing control and IDD groups by brain region.

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    Table 3:

    Interobserver comparison

    Brain RegionKappaAgreement Rating*
    Frontal0.268Fair
    Temporal0.144Slight
    Parietal0.339Fair
    Peritrigonal−0.047Poor
    FUF0.313Fair
    TUF0.343Fair
    PUF0.300Fair
    • Note:—FUF indicates frontal U-fibers; PUF, parietal U-fibers; TUF, temporal U-fibers.

    • * <0 indicates poor; 0–0.20, slight; 0.21–0.40, fair; 0.41–0.60, moderate; 0.61–0.80, substantial; 0.81–1.0, almost perfect. Adapted from Landis and Koch.17

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American Journal of Neuroradiology: 28 (8)
American Journal of Neuroradiology
Vol. 28, Issue 8
September 2007
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S.M. Maricich, P. Azizi, J.Y. Jones, M.C. Morriss, J.V. Hunter, E.O. Smith, G. Miller
Myelination as Assessed by Conventional MR Imaging is Normal in Young Children with Idiopathic Developmental Delay
American Journal of Neuroradiology Sep 2007, 28 (8) 1602-1605; DOI: 10.3174/ajnr.A0602

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Myelination as Assessed by Conventional MR Imaging is Normal in Young Children with Idiopathic Developmental Delay
S.M. Maricich, P. Azizi, J.Y. Jones, M.C. Morriss, J.V. Hunter, E.O. Smith, G. Miller
American Journal of Neuroradiology Sep 2007, 28 (8) 1602-1605; DOI: 10.3174/ajnr.A0602
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