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Research ArticleBrain

Reliability of MR Perfusion-Weighted and Diffusion-Weighted Imaging Mismatch Measurement Methods

M. Luby and S. Warach
American Journal of Neuroradiology October 2007, 28 (9) 1674-1678; DOI: https://doi.org/10.3174/ajnr.A0643
M. Luby
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S. Warach
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    Fig 1.

    Mismatch Method 2. DWI sequence (A) is contrasted to maximize the lesion conspicuity (B) and its intensity values are inverted (C) and then blended with the registered MTT sequence (D). Mismatch Method 1 (E): separate lesion measurements on DWI and MTT sequences compared with Mismatch Method 2 (F): single measurement of the blended difference. Mismatch Method 1 (G): separate lesion measurements on DWI and MTT sequences compared with Mismatch Method 2 (H): single measurement of the blended difference with an arrow indicating the larger MTT lesion seen on the blended map.

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    Fig 2.

    A, Mismatch Method 1, acute time point plot of mean volume vs volume difference between 2 sets of measurements (raw numbers) where the thick black lines represent the upper and lower boundaries using ±2 SDs from the mean. B, Mismatch Method 2, acute time point plot of mean volume vs volume difference between 2 sets of measurements (raw numbers) where the thick black lines represent the upper and lower boundaries using ±2 SDs from the mean. C, Mismatch Method 1, acute time point plot of mean percentage vs percentage difference between 2 sets of measurements (mismatch/MTT percentage) where the thick black lines represent the upper and lower boundaries using ±2 SDs from the mean. D, Mismatch Method 2, acute time point plot of mean percentage vs percentage difference between 2 sets of measurements (mismatch/MTT percentage) where the thick black lines represent the upper and lower boundaries using ±2 SDs from the mean.

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    Table 1:

    Mismatch volume reliability and comparison

    Mismatch VolumeRead 1 Average Acute (n = 64)Read 2 Average Acute (n = 64)Spearman Correlation CoefficientAbsolute Volume Difference, Mean ± SD, Median% Deviation, Mean ± SD, Median
    Method 190.4584.650.96113.83 ± 23.85, 4.8524.68 ± 90.35, 7.67
    Method 283.1582.160.97513.23 ± 13.76, 7.5722.79 ± 37.22, 14.49
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    Table 2:

    Mismatch percentage reliability and comparison

    Mismatch VolumeRead 1 Average % (Mismatch Volume/ MTT Volume) Acute (n = 64)Read 2 Average % (Mismatch Volume/ MTT Volume) Acute (n = 64)Spearman Correlation Coefficient (Mismatch Volume/ MTT Volume)Cases with 20% or More Mismatch (Mismatch Volume/ MTT Volume), Read 1Cases with 20% or More Mismatch (Mismatch Volume/ MTT Volume), Read 2
    Method 159.3351.920.9665252
    Method 271.1173.710.6455557
    • Note:—MTT indicates mean transit time.

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American Journal of Neuroradiology: 28 (9)
American Journal of Neuroradiology
Vol. 28, Issue 9
October 2007
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Cite this article
M. Luby, S. Warach
Reliability of MR Perfusion-Weighted and Diffusion-Weighted Imaging Mismatch Measurement Methods
American Journal of Neuroradiology Oct 2007, 28 (9) 1674-1678; DOI: 10.3174/ajnr.A0643

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Reliability of MR Perfusion-Weighted and Diffusion-Weighted Imaging Mismatch Measurement Methods
M. Luby, S. Warach
American Journal of Neuroradiology Oct 2007, 28 (9) 1674-1678; DOI: 10.3174/ajnr.A0643
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