Preprocedural C-Reactive Protein Levels Predict Stroke and Death in Patients Undergoing Carotid Stenting

Article Figures & Data

Table 1:

Baseline characteristics of patients with and without available CRP values

	With CRP (n = 130)	Without CRP (n = 148)	P Values
Mean age (years)	68.5 (±10.1)	69.1 (±8.9)	.583
Age >80 years	10 (13%)	18 (12.2%)	.237
Male	97 (74.6%)	96 (64.9%)	.116
Hypertension	102 (78.5%)	123 (83.1%)	.279
Hyperlipidemia	68 (52.3%)	79 (53.4%)	.904
Current tobacco use	41 (31.5%)	36 (24.3%)	.282
Diabetes mellitus	35 (26.9%)	38 (25.7%)	1.0
Coronary artery disease	29 (22.3%)	46 (31.1%)	.170
Contralateral ICA occlusion	14 (10.8%)	11 (7.4%)	.211
Contralateral ICA stenosis	25 (19.2%)	28 (18.9%)	1.0
(≥50%)

Table 2:

Patient characteristics according to preprocedural CRP levels*

	Normal CRP	Elevated CRP^†	P Value
Demographic
n	94 (72.3%)	36 (27.7%)
Mean age (years)	67.9 (±10.3)	69.9 (±9.7)	.330
Age >80 years	5 (5.3%)	5 (13.9%)	.139
Male	65 (69.1%)	32 (88.9%)	.024
Presentation
Stroke	43 (45.7%)	18 (50.0%)	.698
Hemispherical TIA	37 (39.4%)	15 (41.7%)	.843
Retinal TIA	14 (14.9%)	3 (8.3%)	.396
Symptom onset to CAS (days)	21.7 (±18.4)	25.3 (±28.3)	.529
Medical conditions
Hypertension	72 (76.6%)	30 (83.3%)	.481
Hyperlipidemia	50 (53.2%)	18 (50.0%)	.845
Current tobacco use	31 (32.0%)	10 (27.8%)	.675
Diabetes mellitus	22 (23.4%)	13 (36.1%)	.185
Coronary artery disease	21 (22.3%)	8 (22.2%)	1.0
Radiological conditions
Carotid artery stenosis right	41 (43.6%)	20 (55.6%)	.331
Degree of stenosis (%)	89.3 (±6.2)	87.8 (±8.9)	.297
Contralateral ICA occlusion	8 (8.5%)	6 (16.7%)	.210
Contralateral ICA stenosis (≥50%)	20 (21.3%)	5 (13.9%)	.458
Carotid protection	24 (27.0%)	8 (25%)	1.0
Current medication
Statins	30 (31.9%)	14 (38.9%)	.535
Angiotensin-converting enzyme inhibitors	39 (41.9%)	18 (50.0%)	.432
β-Adrenergic receptor blockers	25 (26.6%)	8 (22.2%)	.660
Diuretics	23 (24.5%)	14 (38.9%)	.129
Serum parameters
Cholesterol (mg/dL)	205 (±49.5)	195.2 (±44.6)	.292
Triglyceride (mg/dL)	179.9 (±134.6)	189.7 (±106.2)	.726
LDL (mg/dL)	138.0 (±39.9)	132.6 (±32.5)	.649
HDL (mg/dL)	47.8 (±13.6)	43.2 (±8.2)	.254
CRP (mg/L)	0.7 (±1.5)	12.9 (±11.6)	.001

Note:—CAS indicates carotid artery stent; CRP, C-reactive protein, HDL, high-density lipoprotein; ICA, internal carotid artery; LDL, low-density lipoprotein; TIA, transient ischemic attack.
* Data are mean values ± SD or n (%).
† Elevated CRP values refer to >5 mg/L.