Article Figures & Data
Figures
- Fig 1.
Graph of neurologic scores (mean ± SD) for the moderate-severe VSPdelayed group, mild VSPdelayed group, and sham group. Animals with moderate-severe VSPdelayed had greater neurologic deficit than animals with mild VSPdelayed (asterisk, P < .01) and sham animals (number sign, P < .01).
- Fig 2.
Brain stem sections. After SAH, eosinophilic neurons are evident at 24 hours (A), and by 16 days, there are astrocytes and scattered macrophages (B). There is no damage at 24 hours (C) or 16 days (D) after the sham procedure (H&E, ×20).
- Fig 3.
Basilar artery diameter (mean ± SD) before SAH (baseline) and after SAH for animals with mild and moderate-severe VSPdelayed. In the mild VSPdelayed group, arterial diameter was significantly less than baseline on days 2 and 4 (number sign, P < .01 compared with baseline). In the moderate-severe VSPdelayed group, arterial diameter was significantly less than baseline 2, 4, and 7 days after SAH (asterisk, P < .01 compared with baseline).
- Fig 4.
CT perfusion measurements of MTT in the brain stem, cerebellum, parieto-occipital cerebrum, and deep gray matter. In the moderate-severe VSPdelayed group, MTT was significantly greater than both the mild VSPdelayed and sham groups (asterisk, P < .01 compared with sham; double asterisks, P < .01 compared with both mild and sham).
- Fig 5.
CT perfusion maps of MTT. MTT in an animal with mild delayed vasospasm (<24%) does not change in the brain stem (BS) or the cerebellum (CB) between baseline (A) and day 4 (B). In moderate-severe delayed vasospasm (≥24%), MTT increases from baseline (C) to day 4 (D) in the BS and CB. The white arrows show areas of increased MTT.
- Fig 6.
Scatterplot of basilar artery diameter (millimeters) versus MTT (seconds) in the brain stem. There is a significant negative correlation between MTT and basilar artery diameter (P < .05).
Tables
Acute and delayed vasospasm results
Vasospasm Group Day of VSPdelayed Severity of VSPdelayed* Severity of VSPacute* Moderate-severe 2 27 58 Moderate-severe 4 24 40 Moderate-severe 2 41 29 Moderate-severe 4 59 55 Moderate-severe 4 30 0 Moderate-severe 4 49 0 Moderate-severe 4 46 28 Moderate-severe 4 24 35 Average (moderate-severe) 3.5 ± 0.9 37.5 ± 13.1% 30.6 ± 21.8% Mild 2 17 0 Mild 7 15 30 Mild 2 16 0 Mild 4 16 0 Mild 2 17 22 Mild 4 13 50 Mild 4 19 35 Average (Mild) 3.6 ± 2.0 16.1 ± 1.5% 19.6 ± 20.1% * Percentage decrease of basilar artery diameter from baseline.
