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Research ArticleBRAIN

Analysis of 11C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

T. Kato, J. Shinoda, N. Oka, K. Miwa, N. Nakayama, H. Yano, T. Maruyama, Y. Muragaki and T. Iwama
American Journal of Neuroradiology November 2008, 29 (10) 1867-1871; DOI: https://doi.org/10.3174/ajnr.A1242
T. Kato
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J. Shinoda
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N. Oka
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K. Miwa
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N. Nakayama
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H. Yano
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T. Maruyama
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Y. Muragaki
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T. Iwama
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    Fig 1.

    Standard ROI placement. Co-registration of PET and MR imaging was attempted in all cases. The tumor maximal SUV was selected as the highest accumulation in the entire tumor. Also, the mean SUV of the contralateral normal frontal cortex was drawn in 3 circular ROIs with a diameter of 10 mm on each of the 3 axial planes. Left: MET PET. Right: FLAIR image.

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    Fig 2.

    Box plots comparing MET T/N ratio in grade II gliomas. Circles above bars represent outliers (1.5 × the interquartile range). Asterisks represent the mean value. There was a significant difference between the MET T/N ratios of DA and OD (P < .005).

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    Fig 3.

    Left upper: contrast-enhanced T1WI. Right upper: FLAIR image. Left lower: MET PET. Right lower: MET PET is superimposed on contrast-enhanced T1WI. A, A 31-year-old man presented with diffuse astrocytoma that had a lower MET uptake and proliferative activity (MET T/N ratio, 1.00; Mib-1 LI, 1.1%). B, A 37-year-old man presented with diffuse astrocytoma with a higher MET uptake and proliferative activity (MET T/N ratio, 3.25; Mib-1, LI, 5.6%). C, A 35-year-old man presented with oligodendroglioma with a higher MET uptake and lower proliferative activity (MET T/N ratio, 4.71; Mib-1 LI, 3.0%).

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    Fig 4.

    Graph showing the correlation between MET T/N ratio and Mib-1 LI. A significant correlation was shown in diffuse astrocytoma (A; r = 0.63; P < .005). A correlation could not be demonstrated in oligodendroglioma (B) and oligoastrocytoma (C).

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  • Clinical data and histopathologic results*

    Histologic DiagnosisNumber of Patients (M/F)AgeLocation
    FPTI
    Diffuse astrocytoma21 (14/7)40.9 ± 15.28346
    Oligodendroglioma12 (8/4)38.0 ± 13.510200
    Oligoastrocytoma16 (10/6)39.3 ± 13.88323
    Total49 (32/17)39.6 ± 14.126869
    • Note:—F indicates frontal; P, parietal; T, temporal; I, insular.

    • * Data are expressed as mean ± SD.

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American Journal of Neuroradiology: 29 (10)
American Journal of Neuroradiology
Vol. 29, Issue 10
November 2008
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Cite this article
T. Kato, J. Shinoda, N. Oka, K. Miwa, N. Nakayama, H. Yano, T. Maruyama, Y. Muragaki, T. Iwama
Analysis of 11C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity
American Journal of Neuroradiology Nov 2008, 29 (10) 1867-1871; DOI: 10.3174/ajnr.A1242

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Analysis of 11C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity
T. Kato, J. Shinoda, N. Oka, K. Miwa, N. Nakayama, H. Yano, T. Maruyama, Y. Muragaki, T. Iwama
American Journal of Neuroradiology Nov 2008, 29 (10) 1867-1871; DOI: 10.3174/ajnr.A1242
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  • Evaluation of the Accumulation of 11C-Methionine with Standardized Uptake Value in the Normal Brain
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  • Prognostic value of volume-based measurements on 11C-methionine PET in glioma patients
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  • 11C-Methionine Uptake Correlates with Combined 1p and 19q Loss of Heterozygosity in Oligodendroglial Tumors
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