Effects of Age and Symptom Status on Silent Ischemic Lesions after Carotid Stenting with and without the Use of Distal Filter Devices

Article Figures & Data

Table 1:

Baseline characteristics of study population

Variable	Data
Mean age ± SD, y	68 ± 9
≥75 y, n (%)	190 (78)
>75 y, n (%)	53 (22)
Male gender, n (%)	181 (74)
Symptomatic stenosis, n (%)	134 (55)
Hypertension, n (%)	184 (76)
Hyperlipidemia, n (%)	139 (57)
Current tobacco use, n (%)	79 (33)
Diabetes, n (%)	67 (28)
Coronary artery disease, n (%)	54 (22)
Degree of stenosis, mean ± SD, %	88 ± 8
Contralateral ICA occlusion, n (%)	42 (17)

Table 2:

New DWI lesions after CAS according to age or presenting event and treatment

Variable	Unprotected	Protected	P
Age ≤75 y
No. of lesions	52	138
Median (interquartile range)	1 (0–4)	0 (0–2)	<.01
No. of procedures with any new ipsilateral DWI lesion, n/N (%)	35/52 (67)	64/138 (46)	<.05
Age >75 y
No. of lesions	16	37
Median (interquartile range)	1.5 (0–5.75)	1 (0–4)	.6
No. of procedures with any new ipsilateral DWI lesion, n/N (%)	11/16 (69)	27/10 (73)	.7
Symptomatic patients
No. of lesions	47	87
Median (interquartile range)	2 (0–6)	1 (0–3)	<.05
No. of procedures with any new ipsilateral DWI lesion, n/N (%)	35/47 (74)	49/87 (56)	<.05
Asymptomatic patients
No. of lesions	21	88
Median (interquartile range)	1 (0–2.5)	0 (0–2)	.6
No. of procedures with any new ipsilateral DWI lesion, n/N (%)	11/21 (52)	42/88 (48)	.8

Note:—DWI indicates diffusion-weighted imaging; CAS, carotid angioplasty and stent placement.

Table 3:

Periprocedural complications within 30 days after CAS according to age or presenting event and treatment

Variable	Unprotected CAS	Protected CAS	P^*
Age ≤75 y
No.	52	138
Minor stroke, n/N (%)	4/52 (7.7)	5/138 (3.6)	.3
Major stroke, n/N (%)	0/52 (0)	0/138 (0)	NA
Death, n/N (%)	0/52 (0)	0/138 (0)	NA
Any stroke or death, n/N (%)	4/52 (7.7)	5/138 (3.6)	.3
Age >75 y
No.	16	37
Minor stroke, n/N (%)	2/16 (12.5)	2/37 (5.4)	.6
Major stroke, n/N (%)	0/16 (0)	1/37 (2.7)	1.0
Death, n/N (%)^†	0/16 (0)	1/37 (2.7)	1.0
Any stroke or death, n/N (%)	2/16 (12.5)	4/37 (10.8)	1.0
Symptomatic patients
No.	47	87
Minor stroke, n/N (%)	5/47 (10.6)	5/87 (5.7)	.3
Major stroke, n/N (%)	0/47 (0)	0/87 (0)	NA
Death, n/N (%)^†	0/47 (0)	1/87 (1.1)	1.0
Any stroke or death, n/N (%)	5/47 (10.6)	6/87 (6.9)	0.5
Asymptomatic patients
No.	21	88
Minor stroke, n/N (%)	1/21 (4.8)	2/88 (2.2)	.5
Major stroke, n/N (%)	0/21 (0)	1/88 (1.1)	1.0
Death, n/N (%)	0/21 (0)	0/88 (0)	NA
Any stroke or death, n/N (%)	1/21 (4.8)	3/88 (3.4)	.6

Note:—CAS indicates carotid angioplasty and stent placement; NA, not applicable.
* P values are from χ² analysis.
† In the group of patients treated with cerebral protection devices, there was 1 nonstroke-related death secondary to pneumonia 3 weeks after the procedure.