Endovascular Treatment of Experimental Aneurysms with Use of Fibroblast Transfected with Replication-Deficient Adenovirus Containing Bone Morphogenetic Protein-13 Gene

Photomicrographs of aneurysmal necks at 3 months. A, From the PA group, a thin neointima completely transverses the neck. The tissue appears to be concave to the aneurysm cavity (H&E, original magnification 40×). B, From the FBC group, there is a thin collagenous tissue that completely covers the neck (H&E, original magnification 60×). C, From the Ad-BMP-13 group, there is moderately thick collagenous tissue completely across the neck. (H&E, original magnification 60×). All of the tissue traversing the necks is lined with a monolayer of cells contiguous with the endothelium of the parent arteries.

Photomicrographs of collagen formation. A, From the PA group, there is scant collagen within the aneurysm dome at 1 month (Masson trichrome, original magnification 100×). B, from the FBC group, there is local collagen deposition at 3 months (Masson trichrome, original magnification 100×). C–D, Both from the Ad-BMP-13 group, C shows diffuse, collagenous fibers within the dome at 1 month (Masson trichrome, original magnification 100×), and D shows a denser, more mature collagen within the dome at 6 months (Masson trichrome, original magnification 150×)..