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Research ArticleNeurointervention

Outcomes of Ruptured Intracranial Aneurysms Treated by Microsurgical Clipping and Endovascular Coiling in a High-Volume Center

S.K. Natarajan, L.N. Sekhar, B. Ghodke, G.W. Britz, D. Bhagawati and N. Temkin
American Journal of Neuroradiology April 2008, 29 (4) 753-759; DOI: https://doi.org/10.3174/ajnr.A0895
S.K. Natarajan
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L.N. Sekhar
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B. Ghodke
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G.W. Britz
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D. Bhagawati
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N. Temkin
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    Fig 1.

    Pie chart showing the outcomes in the entire group of patients with SAH (DALY indicates daily activities of living).

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    Fig 2.

    Graph showing the outcomes and disabilities of patients according to their admission HH (A) and the presence or absence of ICH (B) in the entire group of patients with SAH.

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    Fig 3.

    A, Graph showing a comparison of the admission WFNS grades in our patients to that of patients in the ISAT study. B, Graph showing a comparison of the outcome in our patients (3 month mRS) to that of patients in the ISAT study (1 year mRS).

Tables

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    Table 1:

    Transcranial Doppler criteria for vasospasms after SAH

    VasospasmMCA VasospasmBA VasospasmACA VasospasmVA VasospasmPCA Vasospasm
    MCA Velocity (cm/s) & MCA/ICA RatioBA Velocity (cm/s) & BA/VA RatioACA Velocity (cm/s)VA Velocity (cm/s)PCA Velocity (cm/s)
    Mild≥120 & ≥3≥70 & ≥2
    Moderate>150 & ≥3≥85 & ≥2.5≥130≥80≥110
    Severe≥200 & ≥6≥85 & ≥3
    • Note:—SAH indicates subarachnoid hemorrhage; MCA, middle cerebral artery, ICA, internal carotid artery; BA, basilar artery; VA, vertebral artery; ACA, anterior cerebral artery; PCA, posterior cerebral artery.

    • View popup
    Table 2:

    Distribution of aneurysm groups and their location

    LocationTotal (%)Clip (%)Coil (%)
    Anterior communicating artery72 (37.50)34 (32.38)38 (43.68)
    Vertebrobasilar system31 (16.15)17 (16.19)14 (16.09)
    Internal carotid artery21 (10.94)15 (14.29)6 (6.90)
    Middle cerebral artery25 (13.02)21 (20.00)4 (4.60)
    Posterior communicating artery27 (14.06)14 (13.33)13 (14.94)
    Pericallosal11 (5.73)1 (0.95)10 (11.49)
    Multiple5 (2.60)3 (2.86)2 (2.30)
    Total192105 (54.69)87 (45.31)
    • View popup
    Table 3:

    Statistical P values of pretreatment variables as predictors of three-month mRS outcomes considered simultaneously

    VariablesAll Aneurysms
    Age.150
    Sex.927
    Comorbidity.095*
    Admission HH.001†
    Admission Fisher.102
    Admission WFNS.626
    Location.316
    Size >1 cm.986
    Multiple aneurysms.302
    Family history.507
    ICH.013†
    • Note:—mRS indicates modified Rankin Scale; HH, Hunt and Hess; WFNS, World Federation of Neurosurgical Societies; ICH, intracerebral hemorrhage.

    • * Value shows a trend toward statistical significance.

    • † Values are statistically significant.

    • View popup
    Table 4:

    Pretreatment variables in patients with SAH

    VariablesClip (%)Coil (%)
    Age >50 y65 (61.90)58 (66.67)
    Male:female1:1.841:2
    Comorbidity74 (70.48)64 (73.56)
    Average admission HH2.51 ± 1.532.85 ± 1.65
    Average admission Fisher3.18 ± 0.933.27 ± 0.90
    Average admission WFNS2.32 ± 1.662.64 ± 1.72
    Size >1 cm19 (18.10)18 (20.69)
    ICH29 (27.62)22 (25.29)
    Family history4 (3.81)1 (1.15)
    • Note:—SAH indicates subarachnoid hemorrhage; HH, Hunt and Hess; WFNS, World Federation of Neurosurgical Societies; ICH, intracerebral hemorrhage.

    • View popup
    Table 5:

    Differences in vasospasm rates, ICU stays, discharge destination, and outcomes between clipping and coiling before and after controlling for pretreatment variables

    VariablesClipCoilP Value
    Average ICU stay (days)*15.312.8.153
    No. TCD vasospasm (%)65.7†51.7†.022†
    No. papaverine/nicardipine (%)1610.165
    No. angioplasties (%)1811.126
    Discharge destination
    Home‡ (%)43.8†49.4†.022†
    Rehabilitation‡ (%)35.2†23.0†.034†
    Skilled nursing facility‡ (%)12.411.5.709
    Outcomes
    In-hospital mortality (%)8.6†16.1†.220
    3-month mortality (%)8.6†20.7†.116
    Average 3-month mRS1.73†2.28†.613
    • Note:—ICU indicates intensive care unit; TCD, transcranial Doppler studies; mRS, modified Rankin Scale.

    • * Analyzed by linear regression analysis.

    • † Values are statistically significant.

    • ‡ Analysis after excluding patients who died in the hospital.

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American Journal of Neuroradiology: 29 (4)
American Journal of Neuroradiology
Vol. 29, Issue 4
April 2008
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S.K. Natarajan, L.N. Sekhar, B. Ghodke, G.W. Britz, D. Bhagawati, N. Temkin
Outcomes of Ruptured Intracranial Aneurysms Treated by Microsurgical Clipping and Endovascular Coiling in a High-Volume Center
American Journal of Neuroradiology Apr 2008, 29 (4) 753-759; DOI: 10.3174/ajnr.A0895

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Outcomes of Ruptured Intracranial Aneurysms Treated by Microsurgical Clipping and Endovascular Coiling in a High-Volume Center
S.K. Natarajan, L.N. Sekhar, B. Ghodke, G.W. Britz, D. Bhagawati, N. Temkin
American Journal of Neuroradiology Apr 2008, 29 (4) 753-759; DOI: 10.3174/ajnr.A0895
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Cited By...

  • Clinical outcome after surgical clipping or endovascular coiling for cerebral aneurysms: a pragmatic meta-analysis of randomized and non-randomized trials with short- and long-term follow-up
  • Endovascular Management of Distal ACA Aneurysms: Single-Institution Clinical Experience in 22 Consecutive Patients and Literature Review
  • Clipping Versus Coiling for Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis
  • Clinical predictors of delayed cerebral ischemia after subarachnoid hemorrhage: first experience with coil embolization in the management of ruptured cerebral aneurysms
  • Endovascular Treatment or Neurosurgical Clipping of Ruptured Intracranial Aneurysms: Effect on Angiographic Vasospasm, Delayed Ischemic Neurological Deficit, Cerebral Infarction, and Clinical Outcome
  • Does treatment modality affect vasospasm distribution in aneurysmal subarachnoid hemorrhage: differential use of intra-arterial interventions for cerebral vasospasm in surgical clipping and endovascular coiling populations
  • Coiling of Intracranial Aneurysms: A Systematic Review on Initial Occlusion and Reopening and Retreatment Rates
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