Research ArticleNeurointervention
Monitoring of Clopidogrel-Related Platelet Inhibition: Correlation of Nonresponse with Clinical Outcome in Supra-Aortic Stenting
S. Müller-Schunk, J. Linn, N. Peters, M. Spannagl, M. Deisenberg, H. Brückmann and T.E. Mayer
American Journal of Neuroradiology April 2008, 29 (4) 786-791; DOI: https://doi.org/10.3174/ajnr.A0917
S. Müller-Schunk
J. Linn
N. Peters
M. Spannagl
M. Deisenberg
H. Brückmann

References
- ↵Rocca B, Patrono C. Determinants of the interindividual variability in response to antiplatelet drugs. J Thromb Haemost 2005;3:1597–602
- Jaremo P, Lindahl TL, Fransson SG, et al. Individual variations of platelet inhibition after loading doses of clopidogrel. J Intern Med 2002;252:233–38
- Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003;107:2908–13
- ↵Wiviott SD. Clopidogrel response variability, resistance, or both? Am J Cardiol 2006;98:18N–24N
- ↵Serebruany V, Steinhubl SR, Berger PB, et al. Variability in platelet responsiveness to clopidogrel among 544 individuals. J Am Coll Cardiol 2005;45:246–51
- ↵Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. High clopidogrel loading dose during coronary stenting: Effects on drug response and interindividual variability. Eur Heart J 2004;25:1903–10
- ↵Jernberg T, Payne C, Winters K, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J 2006;27:1166–73
- ↵Gurbel PA, Bliden KP, Hayes KM, et al. The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol 2005;45:1392–96
- ↵Nguyen TA, Diodati JG, Pharand C. Resistance to clopidogrel: A review of the evidence. J Am Coll Cardiol 2005;45:1157–64
- ↵Grossmann R, Sokolova O, Schnurr A, et al. Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost 2004;92:1201–06
- ↵Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Lack of association between the p2y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005;116:491–97
- ↵Cuisset T, Frere C, Quilici J, et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost 2006;4:542–49
- Gurbel PA, Lau WC, Bliden KP, et al. Clopidogrel resistance: Implications for coronary stenting. Curr Pharm Des 2006;12:1261–69
- ↵
- ↵Gurbel PA, Bliden KP, Guyer K, et al. Platelet reactivity in patients and recurrent events post-stenting: Results of the prepare post-stenting study. J Am Coll Cardiol 2005;46:1820–26
- ↵Fiorella D, Levy EI, Turk AS, et al. US multicenter experience with the Wingspan stent system for the treatment of intracranial atheromatous disease: Periprocedural results. Stroke 2007;38:881–87
- ↵Toth O, Calatzis A, Penz S, et al. Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood. Thromb Haemost 2006;96:781–88
- ↵Mueller T, Dieplinger B, Poelz W, et al. Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel multiplate(r) analyzer-comparison with two flow cytometric methods. Thromb Res 2007;121:249–58
- ↵Born GV. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 1962;194:927–29
- ↵Eikelboom J, Hankey G. Aspirin resistance: A new independent predictor of vascular events? J Am Coll Cardiol 2003;41:966–68
- ↵Malinin A, Pokov A, Spergling M, et al. Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: The verify thrombosis risk assessment (veritas) study. Thromb Res 2007;119:277–84
- ↵Mani H, Linnemann B, Luxembourg B, et al. Response to aspirin and clopidogrel monitored with different platelet function methods. Platelets 2006;17:303–10
- Alstrom U, Tyden H, Oldgren J, et al. The platelet inhibiting effect of a clopidogrel bolus dose in patients on long-term acetylsalicylic acid treatment. Thromb Res 2007;120:353–59
- ↵Geiger J, Teichmann L, Grossmann R, et al. Monitoring of clopidogrel action: Comparison of methods. Clin Chem 2005;51:957–65
- ↵Ivandic BT, Schlick P, Staritz P, et al. Determination of clopidogrel resistance by whole blood platelet aggregometry and inhibitors of the p2y12 receptor. Clin Chem 2006;52:383–88
- ↵Ringleb PA, Allenberg J, Bruckmann H, et al. 30 day results from the space trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: A randomised non-inferiority trial. Lancet 2006;368:1239–47
- ↵Mas JL, Chatellier G, Beyssen B, et al. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med 2006;355:1660–71
- ↵Jiang WJ, Wang YJ, Du B, et al. Stenting of symptomatic m1 stenosis of middle cerebral artery: An initial experience of 40 patients. Stroke 2004;35:1375–80
- ↵SSYLVIA Study Investigators. Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries (ssylvia): Study results. Stroke 2004;35:1388–92
- ↵McKevitt FM, Randall MS, Cleveland TJ, et al. The benefits of combined anti-platelet treatment in carotid artery stenting. Eur J Vasc Endovasc Surg 2005;29:522–27
- ↵Serebruany VL, Malinin AI, Ziai W, et al. Effects of clopidogrel and aspirin in combination versus aspirin alone on platelet activation and major receptor expression in patients after recent ischemic stroke: For the Plavix Use for Treatment of Stroke (PLUTO-stroke) trial. Stroke 2005;36:2289–92
- ↵
- ↵Eikelboom JW, Hankey GJ, Thom J, et al. Enhanced antiplatelet effect of clopidogrel in patients whose platelets are least inhibited by aspirin: A randomized crossover trial. J Thromb Haemost 2005;3:2649–55
- ↵Hochholzer W, Trenk D, Bestehorn HP, et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol 2006;48:1742–50
- ↵Geisler T, Langer H, Wydymus M, et al. Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation. Eur Heart J 2006;27:2420–25
- ↵Tanaka KA, Szlam F, Kelly AB, et al. Clopidogrel (Plavix) and cardiac surgical patients: Implications for platelet function monitoring and postoperative bleeding. Platelets 2004;15:325–32
- Vats HS, Hocking WG, Rezkalla SH. Suspected clopidogrel resistance in a patient with acute stent thrombosis. Nat Clin Pract Cardiovasc Med 2006;3:226–30
- Wenaweser P, Dorffler-Melly J, Imboden K, et al. Stent thrombosis is associated with an impaired response to antiplatelet therapy. J Am Coll Cardiol 2005;45:1748–52
- Dziewierz A, Dudek D, Heba G, et al. Inter-individual variability in response to clopidogrel in patients with coronary artery disease. Kardiol Pol 2005;62:108–17; discussion 118
- Aleil B, Ravanat C, Cazenave JP, et al. Flow cytometric analysis of intraplatelet vasp phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. J Thromb Haemost 2005;3:85–92
- Matetzky S, Shenkman B, Guetta V, et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 2004;109:3171–75
- Muller I, Besta F, Schulz C, et al. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost 2003;89:783–87
- Malinin A, Pokov A, Spergling M, et al. Monitoring platelet inhibition after clopidogrel with the Verifynow-p2y12(r) rapid analyzer: The Verify Thrombosis Risk Assessment (VERITAS) study. Thromb Res 2007;119:277–84
- ↵Lev EI, Ramchandani M, Garg R, et al. Response to aspirin and clopidogrel in patients scheduled to undergo cardiovascular surgery. J Thromb Thrombolysis 2007;24:15–21
- ↵Lepantalo A, Virtanen K, Heikkila J, et al. Limited early antiplatelet effect of 300mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions. Eur Heart J 2004;25:467–83
- ↵Gurbel PA, Cummings CC, Bell CR, et al. Onset and extent of platelet inhibition by clopidogrel loading in patients undergoing elective coronary stenting: The Plavix Reduction of New Thrombus Occurrence (PRONTO) trial. Am Heart J 2003;145:239–47
- ↵Muller I, Seyfarth M, Rudiger S, et al. Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart 2001;85:92–93
- ↵von Beckerath N, Kastrati A, Wieczorek A, et al. A double-blind, randomized study on platelet aggregation in patients treated with a daily dose of 150 or 75 mg of clopidogrel for 30 days. Eur Heart J 2007;28:1814–19
- ↵Bilsel T, Akbulut T, Yesilcimen K, et al. Single high-dose bolus tirofiban with high-loading-dose clopidogrel in primary coronary angioplasty. Heart Vessels 2006;21:102–07
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S. Müller-Schunk, J. Linn, N. Peters, M. Spannagl, M. Deisenberg, H. Brückmann, T.E. Mayer
Monitoring of Clopidogrel-Related Platelet Inhibition: Correlation of Nonresponse with Clinical Outcome in Supra-Aortic Stenting
American Journal of Neuroradiology Apr 2008, 29 (4) 786-791; DOI: 10.3174/ajnr.A0917
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Monitoring of Clopidogrel-Related Platelet Inhibition: Correlation of Nonresponse with Clinical Outcome in Supra-Aortic Stenting
S. Müller-Schunk, J. Linn, N. Peters, M. Spannagl, M. Deisenberg, H. Brückmann, T.E. Mayer
American Journal of Neuroradiology Apr 2008, 29 (4) 786-791; DOI: 10.3174/ajnr.A0917
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