Article Figures & Data
Figures
- Fig 1.
T2-weighted MR, selected spectra, and metabolic images of Cho, Cr, NAA, and lactate (Lac) in a typical case of hypomyelination (Pelizaeus-Merzbacher disease). Spectral patterns from both white and gray matter show near-normal profiles, with a large NAA signal intensity and near-equal Cho and Cr. Bright signal at the corners of the metabolic images arises from residual lipid signals from the scalp. PPM indicates parts per million.
- Fig 2.
T2-weighted MR, selected spectra, and metabolic images of Cho, Cr, NAA, and lactate (Lac) in a case of rarefaction of white matter (LVWM). Metabolic images clearly show decreased Cr and NAA in T2-hyperintense white matter regions, whereas Cho is largely unchanged. In white matter voxels, the NAA/Cho ratio is approximately 1:1. This patient was diagnosed with LVWM at a very early stage and is 1 of the 2 patients with LVWM misclassified in group 1. PPM indicates parts per million.
- Fig 3.
T2-weighted MR, selected spectra, and metabolic images of Cho, Cr, NAA, and lactate (Lac) in a typical demyelination case (metachromatic leukodystrophy). T2-hyperintense white matter regions are characterized by increased Cho and decreased NAA. The gray matter spectrum (voxel 4) also shows a somewhat decreased NAA/Cho ratio. PPM indicates parts per million.
- Fig 4.
T2-weighted MR, selected spectra, and metabolic images of Cho, Cr, NAA, and lactate (Lac) in a typical patient with Canavan disease. NAA is higher than normal in both white and gray matter regions. Note lower (ie, more normal) NAA levels, as seen in voxel 2 and in the NAA metabolic image, in the deeper white matter where there is less signal-intensity abnormality on the T2-weighted MR image. PPM indicates parts per million.
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