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Research ArticleBRAIN

Multiphase CT Angiography versus Single-Phase CT Angiography: Comparison of Image Quality and Radiation Dose

C.-Y. Yang, Y.-F. Chen, C.-W. Lee, A. Huang, Y. Shen, C. Wei and H.-M. Liu
American Journal of Neuroradiology August 2008, 29 (7) 1288-1295; DOI: https://doi.org/10.3174/ajnr.A1073
C.-Y. Yang
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Y.-F. Chen
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C.-W. Lee
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A. Huang
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Y. Shen
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C. Wei
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H.-M. Liu
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    Fig 1.

    Sequential images of MP-CTA are displayed to show the flow dynamics of a patient with suggested stroke. The right MCA is not initially enhanced in the early arterial phase, and opacification of the distal branches of the right MCA via the collaterals can be appreciated later. The temporal sequence of enhancement also helps differentiate arteries and veins (window/level = 1000/100).

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    Fig 2.

    Sequential images of MP-CTA are displayed to show flow dynamics of a case of DAVF. Increased early draining veins around the left Sylvian fissure, as well as the mildly engorged deep venous drainage, could be observed on the left side (window/level = 1000/100).

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    Fig 3.

    Graph shows CT number as a function of iodine concentration. A, The linear relationships for 2 tube-voltage settings are as follows: at 80 kVp/180 mAs, y = 43.25x + 48.05 (r = 0.997); and at 120 kVp/350 mAs, y = 27.55x + 24.00 (r = 0.996). B, The relationship between iodine concentration and SNR is as follows: for SP-CTA, SNR = 8.577 × iodine concentration +12.864 (r = 0.985); for MP-CTA, SNR = 9.704 × iodine concentration + 13.573 (r = 0.973).

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    Fig 4.

    Boxplot of arterial attenuation in 50 patients scanned with both SP-CTA and MP-CTA protocols. Error bars indicate the range of values of arterial attenuation. Boxes contain all values within the 25th–75th percentiles (interquartile range), and thick black lines represent the median. The arterial enhancement peak phase of the MP-CTA is shown for comparison. A, Boxplot of attenuation of the exact same region of the largest artery in the scanning range, representing enhancement in the large vessel. The 3 circles are outliers measured in 1 patient. B, Boxplot of attenuation of the exact same region of the M2 segment in the scanning range, representing enhancement in the small vessel.

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    Fig 5.

    Comparison of image quality between MP-CTA and SP-CTA. A single section of MP-CTA (A), SP-CTA (B), and MIP reconstruction of MP-CTA (C) and SP-CTA (D) is demonstrated. The MP-CTA images were acquired 10–15 minutes after the SP-CTA; therefore, we could find images at almost the same level for comparison. The phase of maximal arterial enhancement of MP-CTA was selected. Higher attenuation of the vascular opacification is easily appreciated in the MP-CTA. Note that venous contamination in the SP-CTA is greater than that in the MP-CTA, which is more obvious in MIP images; and it may interfere with the differentiation of the arteries and veins. The occlusion of right MCA can be detected in both methods. The MP-CTA is noisier, and the contour of the vessels appears coarser than that in SP-CTA. All images were presented with the same window setting (window/level = 1000/100).

Tables

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    Table 1:

    Parameters of SP-CTA, PCT, and MP-CTA protocol

    ParameterSP-CTAPCTMP-CTA
    Detector number646464
    Scanning modeHelicalCineCine
    Coverage length40.0 mm40.0 mm40.0 mm
    Reconstructed section thickness0.625 mm5.0 mm0.625 mm
    Pitch0.516:1––
    Speed20.62 (mm/rot)––
    Rotation time0.4 second1.0 second1.0 second
    Coverage speed51.55 mm/s––
    No. of images per rotation–8i64i
    Cine time interval–0.5 second0.5 second
    kVp1208080
    mA350180180
    Contrast volume60 mL30 mL30 mL
    CTDI51.72623.31623.31
    Scanning rangeNo limitation40 mm40 mm
    Phase selectionNoYesYes
    • Note:—rot indicates rotation; –, not applicable; CTDI, CT dose index; SP-CTA, single-phase CT angiography; PCT, perfusion CT; MP-CTA, multiphase CT angiography.

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    Table 2:

    Comparison of subjective scoring by observers A and B, expressed on a 5-point scale

    SP-CTAMP-CTA
    Observer AObserver BObserver AObserver B
    Arterial enhancement3.4 ± 0.73.2 ± 0.73.8 ± 0.63.6 ± 0.7
    Detail visibility3.1 ± 0.33.4 ± 0.62.8 ± 0.53.3 ± 0.7
    Noise3.0 ± 0.63.0 ± 0.62.0 ± 0.22.5 ± 0.5
    Venous contamination2.9 ± 0.82.7 ± 0.63.1 ± 0.82.4 ± 0.7
    • View popup
    Table 3:

    Subjective scoring of pooled data from both observers for all patients, expressed on a 5-point scale

    CharacteristicsSP-CTAMP-CTAP value
    Arterial enhancement3.3 ± .73.7 ± .6<.001
    Detail visibility3.2 ± .53.1 ± .6.05
    Noise3.0 ± .62.3 ± .4<.001
    Venous contamination2.8 ± .73.2 ± .8.005
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American Journal of Neuroradiology: 29 (7)
American Journal of Neuroradiology
Vol. 29, Issue 7
August 2008
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Cite this article
C.-Y. Yang, Y.-F. Chen, C.-W. Lee, A. Huang, Y. Shen, C. Wei, H.-M. Liu
Multiphase CT Angiography versus Single-Phase CT Angiography: Comparison of Image Quality and Radiation Dose
American Journal of Neuroradiology Aug 2008, 29 (7) 1288-1295; DOI: 10.3174/ajnr.A1073

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Multiphase CT Angiography versus Single-Phase CT Angiography: Comparison of Image Quality and Radiation Dose
C.-Y. Yang, Y.-F. Chen, C.-W. Lee, A. Huang, Y. Shen, C. Wei, H.-M. Liu
American Journal of Neuroradiology Aug 2008, 29 (7) 1288-1295; DOI: 10.3174/ajnr.A1073
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  • Antegrade Flow Across Incomplete Vessel Occlusions Can Be Distinguished From Retrograde Collateral Flow Using 4-Dimensional Computed Tomographic Angiography
  • Angiographic Reconstructions From Whole-Brain Perfusion CT for the Detection of Large Vessel Occlusion in Acute Stroke
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