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Research ArticleBRAIN

Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model

E.S. Rosenthal, L.H. Schwamm, L. Roccatagliata, S.B. Coutts, A.M. Demchuk, P.W. Schaefer, R.G. Gonzalez, M.D. Hill, E.F. Halpern and M.H. Lev
American Journal of Neuroradiology September 2008, 29 (8) 1471-1475; DOI: https://doi.org/10.3174/ajnr.A1153
E.S. Rosenthal
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L.H. Schwamm
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L. Roccatagliata
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S.B. Coutts
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A.M. Demchuk
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P.W. Schaefer
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R.G. Gonzalez
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M.D. Hill
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E.F. Halpern
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M.H. Lev
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References

  1. ↵
    Del Zoppo GJ, Poeck K, Pessin MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 1992;32:78–86
    CrossRefPubMedWeb of Science
  2. ↵
    Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11
    CrossRefPubMedWeb of Science
  3. Hacke W, Kaste M, Fieschi C, et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274:1017–25
    CrossRefPubMedWeb of Science
  4. Madden KP, Karanjia PN, Adams HP Jr, et al. Accuracy of initial stroke subtype diagnosis in the TOAST study. Trial of ORG 10172 in Acute Stroke Treatment. Neurology 1995;45:1975–79
    Abstract/FREE Full Text
  5. Ezzeddine MA, Lev MH, McDonald CT, et al. CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke 2002;33:959–66
    Abstract/FREE Full Text
  6. Dubey N, Bakshi R, Wasay M, et al. Early computed tomography hypodensity predicts hemorrhage after intravenous tissue plasminogen activator in acute ischemic stroke. J Neuroimaging 2001;11:184–88
    PubMedWeb of Science
  7. Lev M, Nichols S. Computed tomographic angiography and computed tomographic perfusion imaging of hyperacute stroke. Top Magn Reson Imaging 2000;11:273–87
    CrossRefPubMed
  8. ↵
    Wardlaw J, Dorman P, Lewis S, et al. Can stroke physicians and neuroradiologists identify signs of early cerebral infarction on CT? J Neurol Neursosurg Psychiatry 1999;67:651–53
  9. ↵
    Suarez J, Sunshine J, Tarr R, et al. Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thromblysis for acute ischemic stroke. Stroke 1999;30:2094–100
    Abstract/FREE Full Text
  10. Baird AE, Dambrosia J, Janket S, et al. A three-item scale for the early prediction of stroke recovery. Lancet 2001;357:2095–99
    CrossRefPubMedWeb of Science
  11. Jovin TG, Yonas H, Gebel JM, et al. The cortical ischemic core and not the consistently present penumbra is a determinant of clinical outcome in acute middle cerebral artery occlusion. Stroke 2003;34:2426–33
    Abstract/FREE Full Text
  12. Lev MH, Roccatagliata L, Murphy EK, et al. A CTA based, multivariable, “benefit of recanalization” model for acute stroke triage: core infarct size on CTA source images independently predicts outcome. Proceedings of the 42nd Annual Meeting of the American Society of Neuroradiology. Seattle, Wash;2004
  13. Nighoghossian N, Hermier M, Adeleine P, et al. Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator. Stroke 2003;34:458–63
    Abstract/FREE Full Text
  14. ↵
    Molina CA, Alexandrov AV, Demchuk AM, et al. Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 2004;35:151–56
    Abstract/FREE Full Text
  15. ↵
    Koroshetz WJ, Gonzales RG. Imaging stroke in progress: magnetic resonance advances but computed tomography is poised for counterattack. Ann Neurol 1999;46:556–58
    CrossRefPubMed
  16. Koroshetz WJ, Lev MH. Contrast computed tomography scan in acute stroke: “you can't always get what you want but you get what you need.” Ann Neurol 2002;51:415–16
    CrossRefPubMed
  17. Lev MH. CT versus MR for acute stroke imaging: is the “obvious” choice necessarily the correct one? AJNR Am J Neuroradiol 2003;24:1930–31
    FREE Full Text
  18. ↵
    Lev MH, Koroshetz WJ, Schwamm LH, et al. CT or MRI for imaging patients with acute stroke: visualization of “tissue at risk”? Stroke 2002;33:2736–37
    FREE Full Text
  19. ↵
    Axel L. Cerebral blood flow determination by rapid-sequence computed tomography. Radiology 1980;137:679–86
    PubMedWeb of Science
  20. ↵
    Hunter GJ, Hamberg LM, Ponzo JA, et al. Assessment of cerebral perfusion and arterial anatomy in hyperacute stroke with three-dimensional functional CT: early clinical results. AJNR Am J Neuroradiol 1998;19:29–37
    Abstract
  21. ↵
    Hamberg LM, Hunter GJ, Kierstead D, et al. Measurement of cerebral blood volume with subtraction three-dimensional functional CT. AJNR Am J Neuroradiol 1996;17:1861–69
    Abstract
  22. ↵
    Lev MH, Segal AZ, Farkas J, et al. Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: prediction of final infarct volume and clinical outcome. Stroke 2001;32:2021–28
    Abstract/FREE Full Text
  23. ↵
    Khatri P, Neff J, Broderick JP, et al. Revascularization end points in stroke interventional trials: recanalization versus reperfusion in IMS-I. Stroke 2005;36:2400–03
    Abstract/FREE Full Text
  24. ↵
    Tomsick T. TIMI, TIBI, TICI: I came, I saw, I got confused. AJNR Am J Neuroradiol. 2007;28:382–84
    FREE Full Text
  25. ↵
    Budzik R, Pergolizzi R, Putman C. Intraarterial thrombolysis for acute ischemic stroke. Semin Neurosurg 2000;11:107–32
  26. ↵
    Schwamm LH, Rosenthal ES, Swap CJ, et al. Hypoattenuation on CT angiographic source images predicts risk of intracerebral hemorrhage and outcome after intra-arterial reperfusion therapy. AJNR Am J Neuroradiol 2005;26:1798–803
    Abstract/FREE Full Text
  27. ↵
    Lev M, Farkas J, Gemmete J, et al. Acute stroke: improved nonenhanced CT detection—benefits of soft-copy interpretation by using variable window width and center level settings. Radiology 1999;213:150–55
    PubMedWeb of Science
  28. ↵
    Barber PA, Demchuk AM, Zhang J, et al. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. Lancet 2000;355:1670–74
    CrossRefPubMedWeb of Science
  29. ↵
    Camargo EC, Furie KL, Singhal AB, et al. Acute brain infarct: detection and delineation with CT angiographic source images versus nonenhanced CT scans. Radiology 2007;244:541–48
    CrossRefPubMedWeb of Science
  30. Coutts SB, Lev MH, Eliasziw M, et al. ASPECTS on CTA source images versus unenhanced CT: added value in predicting final infarct extent and clinical outcome. Stroke 2004;35:2472–76
    Abstract/FREE Full Text
  31. ↵
    Parsons MW, Pepper EM, Chan V, et al. Perfusion computed tomography: prediction of final infarct extent and stroke outcome. Ann Neurol 2005;58:672–79
    CrossRefPubMedWeb of Science
  32. ↵
    Kent DM, Hill MD, Ruthazer R, et al. “Clinical-CT mismatch” and the response to systemic thrombolytic therapy in acute ischemic stroke. Stroke 2005;36:1695–99
    Abstract/FREE Full Text
  33. ↵
    Messe SR, Kasner SE, Chalela JA, et al. CT and NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch. Stroke 2007;38:2079–84
    Abstract/FREE Full Text
  34. ↵
    Tei H, Uchiyama S, Usui T. Predictors of good prognosis in total anterior circulation infarction within 6 h after onset under conventional therapy. Acta Neurol Scand 2006;113:301–06
    PubMed
  35. ↵
    Schramm P, Schellinger PD, Klotz E, et al. Comparison of perfusion computed tomography and computed tomography angiography source images with perfusion-weighted imaging and diffusion-weighted imaging in patients with acute stroke of less than 6 hours’ duration. Stroke 2004;35:1652–58
    Abstract/FREE Full Text
  36. ↵
    Thijs VN, Adami A, Neumann-Haefelin T, et al. Relationship between severity of MR perfusion deficit and DWI lesion evolution. Neurology 2001;57:1205–11
    Abstract/FREE Full Text
  37. Grotta J. NIHSS/EIC mismatch explains the >1/3 MCA conundrum. Stroke 2003;34:e148–49; author reply e148–49
    CrossRefPubMed
  38. Wintermark M, Reichhart M, Thiran JP, et al. Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002;51:417–32
    CrossRefPubMedWeb of Science
  39. ↵
    Mehta N, Lev MH, Mullins ME, et al. Prediction of final infarct size in acute stroke using cerebral blood flow/cerebral blood volume mismatch: added value of quantitative first pass CT perfusion imaging in successfully treated versus unsuccessfully treated/untreated patients. Proceedings of the 41st Annual Meeting of the American Society of Neuroradiology [abstract]. Washington, DC; April 28–May 2,2003
  40. ↵
    Molina CA, Montaner J, Abilleira S, et al. Time course of tissue plasminogen activator-induced recanalization in acute cardioembolic stroke: a case-control study. Stroke 2001;32:2821–27
    Abstract/FREE Full Text
  41. ↵
    Wechsler LR, Roberts R, Furlan AJ, et al. Factors influencing outcome and treatment effect in PROACT II. Stroke 2003;34:1224–29
    Abstract/FREE Full Text
  42. Smith WS, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432–38
    Abstract/FREE Full Text
  43. ↵
    Flint AC, Duckwiler GR, Budzik RF, et al. Mechanical thrombectomy of intracranial internal carotid occlusion: pooled results of the MERCI and Multi MERCI Part I trials. Stroke 2007;38:1274–80
    Abstract/FREE Full Text
  44. ↵
    Derex L, Nighoghossian N, Hermier M, et al. Early detection of cerebral arterial occlusion on magnetic resonance angiography: predictive value of the baseline NIHSS score and impact on neurological outcome. Cerebrovasc Dis 2002;13:225–29
    PubMed
  45. Nabavi DG, Kloska SP, Nam EM, et al. MOSAIC: Multimodal Stroke Assessment Using Computed Tomography: novel diagnostic approach for the prediction of infarction size and clinical outcome. Stroke 2002;33:2819–26
    Abstract/FREE Full Text
  46. Sims JR, Rordorf G, Smith EE, et al. Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV tPA treatment. AJNR Am J Neuroradiol 2005;26:246–51
    Abstract/FREE Full Text
  47. ↵
    Smith WS, Tsao JW, Billings ME, et al. Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care 2006;4:14–17
    CrossRefPubMedWeb of Science
  48. ↵
    Heiss WD. Ischemic penumbra: evidence from functional imaging in man. J Cereb Blood Flow Metab 2000;20:1276–93
    CrossRefPubMedWeb of Science
  49. ↵
    Koennecke HC. Editorial comment–challenging the concept of a dynamic penumbra in acute ischemic stroke. Stroke 2003;34:2434–35
    FREE Full Text
  50. ↵
    Albers GW, Thijs VN, Wechsler L, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006;60:508–17
    CrossRefPubMedWeb of Science
  51. ↵
    Schaefer PW, Roccatagliata L, Ledezma C, et al. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy. AJNR Am J Neuroradiol 2006;27:20–25
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 29 (8)
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E.S. Rosenthal, L.H. Schwamm, L. Roccatagliata, S.B. Coutts, A.M. Demchuk, P.W. Schaefer, R.G. Gonzalez, M.D. Hill, E.F. Halpern, M.H. Lev
Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model
American Journal of Neuroradiology Sep 2008, 29 (8) 1471-1475; DOI: 10.3174/ajnr.A1153

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Role of Recanalization in Acute Stroke Outcome: Rationale for a CT Angiogram-Based “Benefit of Recanalization” Model
E.S. Rosenthal, L.H. Schwamm, L. Roccatagliata, S.B. Coutts, A.M. Demchuk, P.W. Schaefer, R.G. Gonzalez, M.D. Hill, E.F. Halpern, M.H. Lev
American Journal of Neuroradiology Sep 2008, 29 (8) 1471-1475; DOI: 10.3174/ajnr.A1153
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  • Impact of collaterals on the efficacy and safety of endovascular treatment in acute ischaemic stroke: a systematic review and meta-analysis
  • Comparing Vessel Imaging: Noncontrast Computed Tomography/Computed Tomographic Angiography Should Be the New Minimum Standard in Acute Disabling Stroke
  • Assessment of Intracranial Collaterals on CT Angiography in Anterior Circulation Acute Ischemic Stroke
  • Relative Filling Time Delay Based on CT Perfusion Source Imaging: A Simple Method to Predict Outcome in Acute Ischemic Stroke
  • The Impact of Arterial Collateralization on Outcome after Intra-Arterial Therapy for Acute Ischemic Stroke
  • Prognostic Evaluation Based on Cortical Vein Score Difference in Stroke
  • Clot Burden Score on Admission T2*-MRI Predicts Recanalization in Acute Stroke
  • Computed Tomography Angiography in Hyperacute Ischemic Stroke: Prognostic Implications and Role in Decision-Making
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