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Research ArticleBRAIN

Brain Stem Diffusion-Weighted Imaging Lesion Score: A Potential Marker of Outcome in Acute Basilar Artery Occlusion

T.-H. Cho, N. Nighoghossian, F. Tahon, C. Némoz, M. Hermier, F. Salkine, L. Derex, P. Trouillas, J.-C. Froment and F. Turjman
American Journal of Neuroradiology January 2009, 30 (1) 194-198; DOI: https://doi.org/10.3174/ajnr.A1278
T.-H. Cho
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N. Nighoghossian
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F. Tahon
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C. Némoz
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M. Hermier
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F. Salkine
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L. Derex
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P. Trouillas
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J.-C. Froment
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F. Turjman
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  • Fig 1.
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    Fig 1.

    Brain stem DWI lesion score. A, Medulla. B, Pons. C, Midbrain. Arterial segmentation according to Tatu et al22: 1 indicates anteromedial; 2, anterolateral; 3, lateral; and 4, posterior territories. The total number of brain stem arterial territories with abnormal DWI defines the brain stem DWI lesion score, between 0 and 22.

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    Fig 2.

    Pretreatment DWI (A–C) and ADC maps (E–G) of a 70-year-old woman with right hemiparesis, dysarthria, diplopia, and reduced consciousness. DWI shows limited lesions in the midbrain (arrows, C and G; brain stem DWI lesion score, 1) and in the left cerebellar hemisphere. DSA shows a distal basilar clot (arrow, D) successfully recanalized after intra-arterial tPA (H). Time from symptom onset to treatment was 13 hours 30 minutes. Outcome was favorable at 3 months (mRS, 2).

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    Fig 3.

    Pretreatment DWI (A–C) and ADC maps (E–G) of a comatose 45-year-old man with areactive tetraplegia. DWI shows extensive brain stem lesions (arrows, B and C; brain stem DWI lesion score, 10) and bilateral lesions in the posterior inferior cerebellar arteries and left posterior cerebral artery territories. DSA shows occlusion of the V4 segment of the right vertebral artery and of the lower basilar artery (arrow, D). A TIMI 2 recanalization was achieved after intra-arterial tPA and balloon angioplasty of a 70% proximal basilar stenosis (H). Time from symptom onset to treatment was 14 hours 20 minutes. The patient was in a locked-in syndrome at 3 months (mRS, 5).

Tables

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    Table 1:

    Univariate regression analysis

    Prognostic VariablesOdds Ratio (95% CI)P Value
    NIHSS score1.12 (1.02–1.24).02
    Brain stem DWI score1.94 (1.08–3.48).03
    GCS0.80 (0.64–0.99).04
    Presence of coma9.33 (0.97–90.0).05
    • Note:—CI indicates confidence interval; GCS, Glasgow Coma Scale Score.

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    Table 2:

    Multivariate regression analysis

    VariableP ValueOdds Ratio (95% CI)
    Brain stem DWI score.0261.942 (1.084–3.481)
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American Journal of Neuroradiology: 30 (1)
American Journal of Neuroradiology
Vol. 30, Issue 1
January 2009
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Cite this article
T.-H. Cho, N. Nighoghossian, F. Tahon, C. Némoz, M. Hermier, F. Salkine, L. Derex, P. Trouillas, J.-C. Froment, F. Turjman
Brain Stem Diffusion-Weighted Imaging Lesion Score: A Potential Marker of Outcome in Acute Basilar Artery Occlusion
American Journal of Neuroradiology Jan 2009, 30 (1) 194-198; DOI: 10.3174/ajnr.A1278

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Brain Stem Diffusion-Weighted Imaging Lesion Score: A Potential Marker of Outcome in Acute Basilar Artery Occlusion
T.-H. Cho, N. Nighoghossian, F. Tahon, C. Némoz, M. Hermier, F. Salkine, L. Derex, P. Trouillas, J.-C. Froment, F. Turjman
American Journal of Neuroradiology Jan 2009, 30 (1) 194-198; DOI: 10.3174/ajnr.A1278
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