Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBrain
Open Access

Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study

A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver and D.J. Mikulis
American Journal of Neuroradiology November 2009, 30 (10) 1864-1869; DOI: https://doi.org/10.3174/ajnr.A1774
A. Kassner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.P.L. Roberts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Moran
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F.L. Silver
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.J. Mikulis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. del Zoppo G,
    2. von Kummer R,
    3. Hamann GF
    . Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psychiatry 1998;65:1–9
    FREE Full Text
  2. 2.↵
    1. Smith W,
    2. Sung G,
    3. Starkman S,
    4. et al
    . Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke 2005;36:1432–38
    Abstract/FREE Full Text
  3. 3.↵
    1. Lyden P,
    2. Zivin JA
    . Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence. Cerebrovasc Brain Met Rev 1993;5:1–16
  4. 4.↵
    Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke: The NINDS tPA Stroke Study Group. Stroke 1997;28:2109–18
    Abstract/FREE Full Text
  5. 5.↵
    1. Larrue V,
    2. von Kummer R,
    3. del Zoppo G,
    4. et al
    . Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997;28:957–60
    Abstract/FREE Full Text
  6. 6.↵
    1. Toni D,
    2. Fiorelli M,
    3. Bastianello S,
    4. et al
    . Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on clinical outcome. Neurology 1996;46:41–45
    Abstract/FREE Full Text
  7. 7.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C,
    4. et al
    . Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: The European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274:1017–25
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C,
    4. et al
    . Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Lancet 1998;352:1245–51
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Jaillard A,
    2. Cornu C,
    3. Durieux A,
    4. et al
    . Hemorrhagic transformation in acute ischemic stroke: The MAST-E study. Stroke 1999;30:1326–32
    Abstract/FREE Full Text
  10. 10.↵
    Thrombolytic therapy with streptokinase in acute ischemic stroke: The Multicenter Acute Stroke Trial Europe Study Group. N Engl J Med 1996;335:145–50
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Hacke W,
    2. Kaste M,
    3. Bluhmki E,
    4. et al
    . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Baron J,
    2. von Kummer R,
    3. del Zoppo GJ
    . Treatment of acute ischemic stroke: challenging the concept of a rigid and universal time window. Stroke 1999;30:180–82
    Abstract/FREE Full Text
  13. 13.↵
    1. Furlan A,
    2. Higashida R,
    3. Wechsler L,
    4. et al
    . Intra-arterial prourokinase for acute ischemic stroke: The PROACT II study—A randomized clinical trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Hacke W,
    2. Albers G,
    3. Al-Rawi Y,
    4. et al
    . The desmoteplase in acute ischemic stroke trial (DIAS): a phase II MRI-based 9-hour window acute thrombolysis trial with intravenous desmoteplase. Stroke 2006;36:66–73
    CrossRef
  15. 15.↵
    1. Rowley H
    . Successful patient selection with DWPW-MRI for IV treatment with desmoteplase at 3–9 hours: DIAS and DEDAS trial results. In: Proceedings of the American Society of Neuroradiology, Toronto, Ontario, Canada, May 21–27, 2005
  16. 16.↵
    1. Kassner A,
    2. Roberts T,
    3. Taylor K,
    4. et al
    . Prediction of hemorrhage in acute ischemic stroke using permeability MR imaging. AJNR Am J Neuroradiol 2005;26:2213–17
    Abstract/FREE Full Text
  17. 17.↵
    1. Periaswamy S
    . General-Purpose Medical Image Registration [PhD dissertation]. Hanover, NH: Dartmouth College; 2003
  18. 18.↵
    1. Roberts H,
    2. Roberts TPL,
    3. Brasch RC,
    4. et al
    . Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000;21:891–99
    Abstract/FREE Full Text
  19. 19.↵
    1. Ewing JR,
    2. Knight RA,
    3. Nagaraja TN,
    4. et al
    . Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003;50:283–92
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Stejskal E
    . Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288–92
    CrossRefWeb of Science
  21. 21.↵
    R Development Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2007
  22. 22.↵
    1. Cao Y,
    2. Brown SL,
    3. Knight RA,
    4. et al
    . Effect of intravascular-to-extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging. Magn Reson Med 2005;53:282–93
    CrossRefPubMed
  23. 23.↵
    1. Lin K,
    2. Kazmi KS,
    3. Law M,
    4. et al
    . Measuring elevated microvascular permeability and predicting hemorrhagic transformation in acute ischemic stroke using first-pass dynamic perfusion CT imaging. AJNR Am J Neuroradiol 2007;28:1292–98
    Abstract/FREE Full Text
  24. 24.↵
    1. Bisdas S,
    2. Hartel M,
    3. Cheong LH,
    4. et al
    . Prediction of subsequent hemorrhage in acute ischemic stroke using permeability CT imaging and a distributed parameter tracer kinetic model. J Neuroradiol 2007;34:101–08
    PubMed
  25. 25.↵
    1. Dankbaar JW,
    2. Hom J,
    3. Schneider T,
    4. et al
    . Dynamic perfusion CT assessment of the blood-brain barrier permeability: first pass versus delayed acquisition. AJNR Am J Neuroradiol 2008;29:1671–76
    Abstract/FREE Full Text
  26. 26.↵
    1. Rosell A,
    2. Ortega-Aznar A,
    3. Alvarez-Sabin J,
    4. et al
    . Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 2006;37:1399–406
    Abstract/FREE Full Text
  27. 27.↵
    1. Castellanos M,
    2. Leira R,
    3. Serena J,
    4. et al
    . Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003;34:40–46
    Abstract/FREE Full Text
  28. 28.↵
    1. Montaner J,
    2. Molina CA,
    3. Monasterio J,
    4. et al
    . Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 2003;107:598–603
    Abstract/FREE Full Text
  29. 29.↵
    1. Kastrup A,
    2. Gröschel K,
    3. Ringer TM,
    4. et al
    . Early disruption of the blood–brain barrier after thrombolytic therapy predicts hemorrhage in patients with acute stroke. Stroke 2008;39:2385–87
    Abstract/FREE Full Text
  30. 30.↵
    1. Nyormoi O,
    2. Mills L,
    3. Bar-Eli M
    . An MMP-2/MMP-9 inhibitor, 5a, enhances apoptosis induced by ligands of the TNF receptor superfamily in cancer cells. Cell Death Differ 2003;10:558–69
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 30 (10)
American Journal of Neuroradiology
Vol. 30, Issue 10
1 Nov 2009
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, D.J. Mikulis
Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
American Journal of Neuroradiology Nov 2009, 30 (10) 1864-1869; DOI: 10.3174/ajnr.A1774

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, D.J. Mikulis
American Journal of Neuroradiology Nov 2009, 30 (10) 1864-1869; DOI: 10.3174/ajnr.A1774
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway
  • Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke
  • Impact of Alcohol Consumption on the Outcome of Ischemic Stroke and Thrombolysis: Role of the Hepatic Clearance of Tissue-Type Plasminogen Activator
  • Understanding the Functions of Endogenous and Exogenous Tissue-Type Plasminogen Activator During Stroke
  • Magnetic Resonance Imaging Profile of Blood-Brain Barrier Injury in Patients With Acute Intracerebral Hemorrhage
  • t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes
  • Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage
  • Contrast-Enhanced MR Imaging in Acute Ischemic Stroke: T2* Measures of Blood-Brain Barrier Permeability and Their Relationship to T1 Estimates and Hemorrhagic Transformation
  • Texture Analysis: A Review of Neurologic MR Imaging Applications
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire