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Case ReportBrain

Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation

J.R. Gaughen, T.D. Bourne, D. Aregawi, L.M. Shah and D. Schiff
American Journal of Neuroradiology November 2009, 30 (10) 1933-1935; DOI: https://doi.org/10.3174/ajnr.A1671
J.R. Gaughen
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T.D. Bourne
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D. Aregawi
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L.M. Shah
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D. Schiff
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    Fig 1.

    Comparison study. A and B, Axial postcontrast T1-weighted (A) and T2-weighted (B) images obtained at the completion of final chemotherapy treatment demonstrate no enhancement along the resection margins but faint gyriform contrast enhancement (white arrows) and underlying gliosis (black arrows) in the adjacent frontal lobe.

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    Fig 2.

    At presentation. A and B, Axial postcontrast T1-weighted (A) and T2-weighted (B) images show marked enlargement and nodular enhancement of the right frontal lobe cortex and juxtacortical white matter (white arrows) adjacent to the resection cavity (not shown), with extensive white matter T2 hyperintensity throughout the right frontal white matter (black arrows). The degree of cortical thickening and nodular enhancement have progressed dramatically from that of the previous study.

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    Fig 3.

    Gross and microscopic photographs of the recent resection specimen. A, Gross specimen shows subtle cortical thickening and focal blurring of the gray-white matter interface. B, Enlarged cortical neurons show haphazard polarity (red arrows) (hematoxylin-eosin, original magnification ×400). C, Abnormal giant neurons show loss of normal cortical lamination (black arrows) (neurofilament protein [SMI-33] immunostain, original magnification ×200).

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American Journal of Neuroradiology: 30 (10)
American Journal of Neuroradiology
Vol. 30, Issue 10
1 Nov 2009
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J.R. Gaughen, T.D. Bourne, D. Aregawi, L.M. Shah, D. Schiff
Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation
American Journal of Neuroradiology Nov 2009, 30 (10) 1933-1935; DOI: 10.3174/ajnr.A1671

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Focal Neuronal Gigantism: A Rare Complication of Therapeutic Radiation
J.R. Gaughen, T.D. Bourne, D. Aregawi, L.M. Shah, D. Schiff
American Journal of Neuroradiology Nov 2009, 30 (10) 1933-1935; DOI: 10.3174/ajnr.A1671
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