Article Figures & Data
Figures
- Fig 1.
Axial FLAIR (TR = 9800 ms, TE = 110 ms, NEX = 2) image of a patient with stage 2 disease reveals normal findings.
- Fig 2.
Statistical parametric maps demonstrating the structural difference in gray matter volumes. Significant gray matter volume decrease (P < .05, corrected) is overlaid in color on the normalized T1-weighted images of a healthy control subject. Only clusters of voxels consisting of at least 20 voxels are displayed. The color scale shows the range of Z values. It shows the reduced gray matter volumes in bilateral medial temporal regions, including the amygdala, cingulate gyri, and right inferior frontal gyrus.
Tables
Patient No. Age Sex Duration of Symptoms (weeks) Stage NDI Score IgG Index Symptoms 1 10 M 8 1 10 37 ALP, DSP 2 12 F 3 1 15 37 DSP, DSI, EI 3 7 F 16 2 20 99 Moderate depression, DSI, INS 4 14 F 8 1 10 73 ALP, DSP 5 9 F 5 1 10 113 DSI, EI 6 7 F 24 2 25 108 ALP, DSP, DSI, INS 7 8 F 12 2 15 433 DSP, INS 8 13 F 8 1 15 17 IPE, EI, DSP 9 10 M 6 1 10 13 ALP, DSI 10 9 F 6 1 15 105 EI, IPE 11 10 F 4 1 15 31 ALP, DSP, DSI, EI 12 7 M 5 1 15 709 DSI, IPE 13 13 F 18 2 25 22 ALP, DSP, DSI, INS 14 7 M 8 1 20 161 DSP, EI, IPE 15 9 M 12 2 25 47 DSP, INS 16 9 F 4 1 15 1370 ALP, DSP, DSI, IPE 17 9 M 5 1 10 126 DSP, IPE Note:—ALP indicates altered personality/behavior; DSP, decreased scholastic performance; DSI, decreased social interactions; EI, emotional instability; IPE, inappropriate emotions; INS, involuntary spasms; NDI, neurologic disability index; IgG, immunoglobulin G.
- Table 2:
Cortical regions with decreased gray matter volume in patients compared with control subjects
Anatomic Regions (BA) Talairach Coordinates: Patients vs Control Subjects Max. Z Values X Y Z Left amygdala −32 −1 −12 5.49 Left uncus (BA 38) −27 3 −33 5.24 Left cingulate gyrus (BA 31) −10 −23 38 5.15 Left cingulate gyrus (BA 24) −7 −15 41 5.32 Left superior temporal gyrus (BA 38) −30 4 −11 5.24 Left middle temporal gyrus (BA 37) −46 −59 −1 3.51 Right cingulate gyrus (BA 24) 6 0 35 5.68 Right inferior frontal gyrus (BA 44) 52 3 13 5.16 Right superior temporal gyrus (BA 38) 33 3 −9 5.10 Right fusiform gyrus (BA 20) 52 −35 −19 4.98 Right amygdala 30 −3 −10 5.13 Note:—Max indicates maximum; BA, Brodmann area.
