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Research ArticleHead and Neck Imaging

Can Quantitative Diffusion-Weighted MR Imaging Differentiate Benign and Malignant Cold Thyroid Nodules? Initial Results in 25 Patients

C. Schueller-Weidekamm, K. Kaserer, G. Schueller, C. Scheuba, H. Ringl, M. Weber, C. Czerny and A.M. Herneth
American Journal of Neuroradiology February 2009, 30 (2) 417-422; DOI: https://doi.org/10.3174/ajnr.A1338
C. Schueller-Weidekamm
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K. Kaserer
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G. Schueller
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C. Scheuba
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H. Ringl
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M. Weber
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C. Czerny
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A.M. Herneth
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    Fig 1.

    A patient with follicular thyroid carcinoma in the right thyroid lobe (T2, N0, M0; tumor size, 842 mm2). A, On sagittal DWI EPI MR image (b-value = 0 s/mm2), the tumor appears homogeneously hyperintense (arrow). B, The corresponding ADC map shows high values of the carcinoma (arrow) as a result of unhindered diffusion capability. The diagnosis was confirmed at histology.

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    Fig 2.

    A patient with histologically confirmed adenoma in the lower pole and follicular thyroid carcinoma in the upper pole of the left thyroid lobe (size, 130 mm2; 125 mm2). A, On sagittal DWI EPI MR image (b-value = 0 s/mm2), the adenoma (arrow) and the thyroid carcinoma (open arrow) appear slightly hyperintense. B, The corresponding ADC map shows low ADC values for adenoma (arrow) as a result of restricted diffusion capability. The ADC values for carcinoma (open arrow) are high as a result of unhindered diffusion capability.

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    Fig 3.

    Boxplot of ADC values in thyroid cancer, adenoma, and normal thyroid parenchyma. The horizontal lines are median values, the boxes show minimum and maximum values, and the whiskers indicate 2 SDs. Median ADC values for cancer and adenoma are significantly different, and there is no overlap of absolute values.

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  • Mean ADC values and 95% CI of carcinoma, adenoma, and normal parenchyma*

    DiagnosisADC of Lesions†ADC of Normal Parenchyma*
    Carcinoma (n = 20)2.73 ± 0.65 (2.43–3.04)1.439 ± 0.648 (1.25–1.60)
    Adenoma (n = 5)1.93 ± 0.25 (1.63–2.23)1.341 ± 0.245 (1.18–1.57)
    • Note:—ADC indicates apparent diffusion coefficient.

    • * Data are mean ± SD. Data in parentheses are the ranges of the 95% CI.

    • † ADC values are expressed as the (mean ± SD) × 10−3 mm2/s (P < .05).

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American Journal of Neuroradiology: 30 (2)
American Journal of Neuroradiology
Vol. 30, Issue 2
February 2009
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C. Schueller-Weidekamm, K. Kaserer, G. Schueller, C. Scheuba, H. Ringl, M. Weber, C. Czerny, A.M. Herneth
Can Quantitative Diffusion-Weighted MR Imaging Differentiate Benign and Malignant Cold Thyroid Nodules? Initial Results in 25 Patients
American Journal of Neuroradiology Feb 2009, 30 (2) 417-422; DOI: 10.3174/ajnr.A1338

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Can Quantitative Diffusion-Weighted MR Imaging Differentiate Benign and Malignant Cold Thyroid Nodules? Initial Results in 25 Patients
C. Schueller-Weidekamm, K. Kaserer, G. Schueller, C. Scheuba, H. Ringl, M. Weber, C. Czerny, A.M. Herneth
American Journal of Neuroradiology Feb 2009, 30 (2) 417-422; DOI: 10.3174/ajnr.A1338
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