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Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

J.B. Brewer, S. Magda, C. Airriess and M.E. Smith
American Journal of Neuroradiology March 2009, 30 (3) 578-580; DOI: https://doi.org/10.3174/ajnr.A1402
J.B. Brewer
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S. Magda
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C. Airriess
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M.E. Smith
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    Fig 1.

    Example coronal sections from automatically segmented MR images from a healthy brain (left) and a patient with AD (right). Arrows indicate medial temporal lobe structures. Colors indicate segmented structures as listed in the Table.

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  • Manual vs automated segmentation

    Brain RegionICCPearson r
    Cerebral white matter0.98*0.98*
    Cerebral gray matter0.92*0.93*
    Cerebellum0.96*0.93†
    Third ventricle0.93*0.92*
    Fourth ventricle0.93*0.90*
    Lateral ventricle0.99*0.99*
    Inferior lateral ventricle0.92*0.89*
    Hippocampus0.93*0.88*
    Amygdala0.77*0.77*
    Thalamus0.9*0.87*
    Caudate0.82*0.75*
    Putamen0.89*0.85*
    Pallidum0.76*0.69*
    Ventral diencephalon0.86*0.80*
    Nucleus accumbens0.61†0.69*
    Brain stem0.93*0.94*
    • Note:—ICC indicates intraclass correlation coefficient.

    • * P < .001.

    • † P < .002.

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American Journal of Neuroradiology: 30 (3)
American Journal of Neuroradiology
Vol. 30, Issue 3
March 2009
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J.B. Brewer, S. Magda, C. Airriess, M.E. Smith
Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease
American Journal of Neuroradiology Mar 2009, 30 (3) 578-580; DOI: 10.3174/ajnr.A1402

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Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease
J.B. Brewer, S. Magda, C. Airriess, M.E. Smith
American Journal of Neuroradiology Mar 2009, 30 (3) 578-580; DOI: 10.3174/ajnr.A1402
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