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Research ArticleBRAIN
Open Access

The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst

C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts and A.R. Mayes
American Journal of Neuroradiology April 2009, 30 (4) 736-743; DOI: https://doi.org/10.3174/ajnr.A1424
C.E. Denby
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S.D. Vann
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D. Tsivilis
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J.P. Aggleton
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D. Montaldi
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N. Roberts
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A.R. Mayes
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  • Fig 1.
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    Fig 1.

    The stereologic procedure for measuring the mammillary bodies. A and B, Mammillary body location and detailed structure. C, Placement of the stereologic grid. D, Method of stereologic point counting. The mammillary body volume estimate is contained within the area indicated by the white arrows.

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    Fig 2.

    Comparison of the resolution of the 1 × 1 × 1 mm isotropic volume scan (A) with the 0.8-mm thin-section volume scan (B) in a patient with relatively normal mammillary body volumes. The 2 sections are taken from neighboring sections around the central region of the patient's mammillary bodies and show the higher resolution of the 0.8-mm scan and the resultant benefit for the identification of the mammillary body landmarks.

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    Fig 3.

    Distribution of intracranial normalized control and patient mammillary body volumes.

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    Fig 4.

    Cumulative classification of intracranial normalized patient mammillary body volumes according to the percentage of cases with atrophy below the control mean by using z-scores (1-sample t tests, 1-tailed).

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    Fig 5.

    The range of atrophy across our study population. A, Healthy mammillary bodies from a control subject. B, Mild asymmetry in a patient with a colloid cyst. C and D, Severe mammillary body atrophy in the patient group. R indicates right; L, left.

Tables

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    Table 1:

    Mean absolute volume estimates, SDs, and volume ranges for the right and left mammillary bodies in the patients with colloid cysts and control subjects

    CystPatients (n = 38)Controls (n = 20)
    Mean (SD) (mm3)RangeMean (SD) (mm3)Range
    0.8 mm
        Right38 (20)4–6769 (11)44–86
        Left39 (22)3–7367 (10)44–80
    1.0 mm
        Right38 (16)5–7256 (9)41–83
        Left42 (19)7–7255 (16)38–75
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    Table 2:

    Mean intracranial-volume normalized ratios, SDs, and volume ranges for the right and left mammillary bodies in patients with colloid cysts and controls

    CystPatients (n = 38)Controls (n = 20)
    Mean (SD)RangeMean (SD)Range
    .08 mm
        Right0.030 (0.015)0.038–0.0530.060 (0.014)0.034–0.098
        Left0.031 (0.018)0.020–0.0570.057 (0.013)0.042–0.09
    1.0 mm
        Right0.032 (0.016)0.007–0.0480.047 (0.080)0.037–0.064
        Left0.035 (0.015)0.007–0.0590.047 (0.050)0.038–0.054
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    Table 3:

    Number of patients and SDs below the control mean for the normalized mammillary body

    SD below the Control MeanNormalized Mammillary Body Volume
    RightLeft
    0 to −1710
    −1 to −21411
    −2 to −397
    −3 to −484
    −4 to −506
    Total3838
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American Journal of Neuroradiology: 30 (4)
American Journal of Neuroradiology
Vol. 30, Issue 4
April 2009
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Cite this article
C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts, A.R. Mayes
The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst
American Journal of Neuroradiology Apr 2009, 30 (4) 736-743; DOI: 10.3174/ajnr.A1424

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The Frequency and Extent of Mammillary Body Atrophy Associated with Surgical Removal of a Colloid Cyst
C.E. Denby, S.D. Vann, D. Tsivilis, J.P. Aggleton, D. Montaldi, N. Roberts, A.R. Mayes
American Journal of Neuroradiology Apr 2009, 30 (4) 736-743; DOI: 10.3174/ajnr.A1424
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