Article Figures & Data
Figures
- Fig 1.
CECT (A) and PCT parametric maps (B-E) of a male patient with SCCA carcinoma in the oropharynx and oral cavity (arrows) as well as enlarged lymph nodes (arrowheads) in Levels I and II on both sides. B, BF map. C, BV map. D, MTT. E, PS map.
- Fig 2.
Kaplan-Meier survival analysis showing the predictive value of tumor volume (A) and BF (B) values for progression-free survival.
- Fig 3.
ROC analysis of BF measurements vs recurrence (A) and induction chemotherapy response (B).
Tables
Pt No. Age (y)/Sex TNM Staging Tumor Response PFS 1 40/M T3N2aM0 PR 6 2 34/M T4N2cM0 PR 14 3 57/M T4N1M0 SD 6 4 59/M T4N2cM0 SD 12 5 45/M T4N3M0 PR 11 6 55/F T4N2bM0 PR 24 7 59/M T4N3M0 SD 4 8 62/M T4N2cM0 SD 24 9 61/M T4N3M0 SD 14 10 47/M T4N2cM0 PR 15 11 72/M T4N3M0 PR 6 12 49/M T4N2cM0 SD 8 13 57/M T4N2cM0 PR 8 14 64/M T4N1M0 PR 4 15 53/M T4N2cM0 SD 11 16 56/M T4N3M0 SD 5 17 62/F T4N2cM0 PR 10 18 65/M T4N3M0 PR 13 19 59/M T4N2cM0 PR 12 Note:—TNM indicates tumors, nodes, and metastasis; PR indicates partial response; SD, stable disease; PFS, progression-free survival (in months).
- Table 2:
ROC curve analysis results for the prediction of response to induction chemotherapy based on the pretreatment tumor volume and the perfusion-associated parameters*
Response Cutoff Value Sensitivity (%) Specificity (%) AUC P Value Pretreatment tumor volume (mL) ≤15.3 100 (99.1–100) 33.3 (26.5–40.7) 0.50 .84 Blood flow (mL/100 g/min) ≤66.2 84.2 (79.8–89.7) 66.7 (59.3–73.5) 0.63 .0001 Blood volume (mL/100 g) >7.4 100 (98.9–100) 30.6 (23.9–37.8) 0.59 .0005 Mean transit time (s) <8.5 43.7 (38.4–49.1) 100 (98–100) 0.62 .0001 Permeability (mL/100 g/min) >8.6 65.4 (60.1–70.4) 100 (98–100) 0.78 .0001 Note:—AUC indicates area under the curve.
* The values (95% CI) represent thresholds above or below of which the patients will show a response.
