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Research ArticleINTERVENTIONAL
Open Access

Neurovascular Modeling: Small-Batch Manufacturing of Silicone Vascular Replicas

J.Y. Chueh, A.K. Wakhloo and M.J. Gounis
American Journal of Neuroradiology June 2009, 30 (6) 1159-1164; DOI: https://doi.org/10.3174/ajnr.A1543
J.Y. Chueh
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A.K. Wakhloo
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M.J. Gounis
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    Fig 1.

    Virtual cerebrovascular models show ICA siphons with mild (A), medium (B), and severe (C) curvature.

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    Fig 2.

    The virtual core-shell structure (A) is designed for the preparation of the physical ABS model (B), which contains the CoW (C) as the core. After the silicone is cured, the ABS model (B) is dissolved in xylene, resulting in a transparent CoW silicone replica (D). E, With the same manufacturing process, a representative right ICA siphon is built from patient 18.

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    Fig 3.

    The S-S curves of Sylgard 184, LIM 6030, and a human MCA from postmortem examination are compared. At low stretch, the elastic property of LIM 6030 is close to that of the MCA from postmortem examination. Short solid line indicates the MCA from a postmortem examination; dark dashed line, LIM 0.49 mm in thickness; light dashed line, LIM 0.52 mm in thickness; dotted line, LIM 0.53 mm in thickness; diamond, Sylgard 0.49 mm in thickness; square, Sylgard 0.53 mm in thickness; triangle, 0.61 mm in thickness.

Tables

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  • Static and dynamic COFs of Sylgard 184 and LIM 6030 samples for different numbers of coatings after 25 runs*

    Coating No.Sylgard 184LIM 6030
    Static COFDynamic COFStatic COFDynamic COF
    00.738 ± 0.0930.707 ± 0.0891.346 ± 0.1131.298 ± 0.113
    10.334 ± 0.169 (P = .0016)0.312 ± 0.174 (P = .0019)1.052 ± 0.216 (P = .0273)1.026 ± 0.222 (P = .0435)
    20.366 ± 0.114 (P = .0005)0.312 ± 0.108 (P = .0002)0.815 ± 0.114 (P < .0001)0.765 ± 0.098 (P < .0001)
    30.471 ± 0.091 (P = .0018)0.416 ± 0.090 (P = .0009)0.719 ± 0.121 (P < .0001)0.683 ± 0.120 (P < .0001)
    • Note:—COF indicates coefficient of friction.

    • * The COF is presented as mean ± SD. The Student t test compares the mean COF of the coated and uncoated groups. The 2-tailed P value < .05 indicates a statistically significant difference.

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American Journal of Neuroradiology: 30 (6)
American Journal of Neuroradiology
Vol. 30, Issue 6
June 2009
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J.Y. Chueh, A.K. Wakhloo, M.J. Gounis
Neurovascular Modeling: Small-Batch Manufacturing of Silicone Vascular Replicas
American Journal of Neuroradiology Jun 2009, 30 (6) 1159-1164; DOI: 10.3174/ajnr.A1543

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Neurovascular Modeling: Small-Batch Manufacturing of Silicone Vascular Replicas
J.Y. Chueh, A.K. Wakhloo, M.J. Gounis
American Journal of Neuroradiology Jun 2009, 30 (6) 1159-1164; DOI: 10.3174/ajnr.A1543
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