A Prospective Study of Fetuses with Isolated Ventriculomegaly Investigated by Antenatal Sonography and In Utero MR Imaging

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Fig 1.
In utero MR imaging (iuMR) scans of a fetus at 23 weeks’ gestational age thought to have isolated ventriculomegaly (VM) on sonography. A and B, Axial (A) and a montage of 4 consecutive coronal single-shot fast spin-echo images (B) show agenesis of the corpus callosum with colpocephaly.
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Fig 2.
A fetus depicted on iuMR at 30 weeks’ gestational age because of VM. A and B, Axial (A) and a montage of 4 consecutive coronal single-shot fast spin-echo images (B) show agenesis of the corpus callosum with colpocephaly.
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Fig 3.
iuMR images of a fetus at 31 weeks’ gestational age thought to have isolated VM on sonography. Axial (A) and a montage of 4 consecutive coronal single-shot fast spin-echo images (B) show agenesis of the corpus callosum and an associated interhemispheric cyst. The cortex adjacent to the cyst was interpreted as abnormal, but no formal confirmation of that finding is now available.

Risk of detecting brain abnormalities on iuMR relative to the degree of VM of the fetus^a

	Mild VM	Moderate VM	Severe VM
Overall risk of another brain abnormality	6% (2%–12%)	14% (4%–2%)	57% (37%–76%)
	5/90	4/29	16/28
Overall relative risk compared with mild VM	1	2.5 (0.7–8.6)	10.3 (4.1–25.6)^b
Risk of another brain abnormality in 20–24 w group	6% (2%–14%)	17% (4%–41%)	22% (3%–60%)
	4/72	3/18	2/9
Relative risk compared with mild VM (20–24 w)	1	3.0 (0.7–12.2)	4.0 (0.8–18.8)
Risk of another brain abnormality in 25 w+ group	6% (0%–27%)	9% (0%–41%)	74% (49%–91%)
	1/18	1/11	14/19
Relative risk compared with mild VM (25 w+)	1	1.6 (0.1–23.6)	13.3 (1.9–90.8)^b