Article Figures & Data
Figures
- Fig 1.
A–H, Example of the FIRST segmentation of the striata and thalami (light blue indicates the caudate; light green, the pallidus; yellow ochre, the putamen; lilac, the thalamus) in HD gene carrier in clinical stage I (A–D), which was manually edited on the basis of the structure contour identified in the subject's heavily T1-weighted images (E–H). A–D, The automatic definition of the cortical GM ribbon performed by the in-house-developed software is also displayed with different colors corresponding to the 4 cerebral lobes (yellow indicates frontal; green, parietal-insular; dark blue, temporal; red, occipital).
- Fig 2.
Plots showing correlation between clinical variables (disease duration, motor UHDRS, Verbal Fluency test, and Symbol Digit test) and MT ratio measurements in the temporal lobe cortex (A,C) and putamen (B,D).
Tables
Mean Range Age (yr) 56 ± 12 34–75 CAG repeat size 44 ± 3 40–50 Sex (M:F) 8:7 Disease duration (yr) 6.9 ± 6.6 0–28 UHDRS motor score 33 ± 18 0–57 Verbal Fluency test 13 ± 11 3–40 Symbol Digit test 19 ± 19 0–66 Stroop Color Word Interference Test 25 ± 34 3–120 - Table 2:
Volumes and MT ratios of the striatal nuclei and thalami in 15 healthy controls and 15 HD carriers
Mean Volume (mm3) Mean MT Ratio Controls HD carriers P Valuea Controls HD Carriers P Valuea Caudate nuclei 6221 ± 806 3048 ± 1834 <.001 55.0 ± 0.9 51.8 ± 3.2 <.01 Putamen 7222 ± 886 4374 ± 1590 <.001 55.4 ± 0.7 54.1 ± 1.6 NS Globi pallidi 3061 ± 321 1513 ± 553 <.001 56.9 ± 0.8 55.4 ± 1.5 .02 Thalami 10551 ± 1197 9802 ± 1908 NS 58.6 ± 0.7 56.8 ± 1.9 <.01 a Mann-Whitney U test with Bonferroni correction.
- Table 3:
Mean normalized volumes and MT ratios of the cerebral cortical GM in 15 healthy controls and 15 HD carriers
Lobes Mean Normalized Volume (mm3) Mean MT Ratio Controls HD Carriers P Valuea Controls HD Carriers P Valuea Frontal 202 ± 16 179 ± 19 <.01 55.1 ± 0.9 50.7 ± 3.5 <.001 Parietal 161 ± 15 135 ± 20 <.01 54.5 ± 0.8 51.4 ± 2.9 <.01 Temporal 143 ± 11 128 ± 13 .02 54.9 ± 0.8 51.7 ± 2.7 <.01 Occipital 91 ± 10 72 ± 10 <.01 53.2 ± 1.3 48.2 ± 3.4 <.01 a Mann-Whitney U test with Bonferroni correction.
- Table 4:
Spearman rank correlation coefficients between the clinical-genetic variables and volumes and MT ratios in 15 HD carriers
No. of Triplets Disease Duration Motor UHDRS Verbal Fluency Symbol Digit Stroop R P R P R P R P R P R P Volumes NWMV 0.46 NS −0.22 NS −0.44 NS 0.44 NS 0.65 <.01 0.54 .04 NGMV −0.16 NS −0.50 NS −0.67 <.01 0.65 <.01 0.41 NS 0.40 NS Frontal cortex −0.40 NS −0.60 .02 −0.59 .02 0.65 <.01 0.33 NS 0.31 NS Parietal cortex −0.38 NS −0.67 <.01 −0.60 .02 0.74 <.01 0.37 NS 0.37 NS Temporal cortex −0.32 NS −0.45 NS −0.62 .01 0.60 .02 0.34 NS 0.45 NS Occipital cortex −0.07 NS −0.36 NS −0.66 <.01 0.77 <.001 0.61 .01 0.68 <.01 Caudate nuclei −0.16 NS −0.55 .03 −0.80 <.001 0.65 <.01 0.53 .04 0.46 NS Putamen −0.24 NS −0.59 .02 −0.78 <.001 0.59 .02 0.50 NS 0.49 NS Globi pallidi −0.14 NS −0.63 .01 −0.79 <.001 0.51 .0496 0.46 NS 0.37 NS Thalami −0.24 NS −0.34 NS −0.71 <.01 0.57 .03 0.51 NS 0.62 .01 MT ratios WM −0.14 NS −0.72 <.01 −0.81 <.001 0.73 <.01 0.64 .01 0.64 .01 GM −0.25 NS −0.68 <.01 −0.81 <.001 0.88 <.0001 0.57 .04 0.58 .03 Frontal cortex −0.34 NS −0.65 <.01 −0.55 .03 0.61 .02 0.26 NS 0.23 NS Parietal cortex −0.26 NS −0.66 <.01 −0.64 .01 0.63 .01 0.34 NS 0.30 NS Temporal cortex −0.05 NS −0.77 <.001 −0.77 <.001 0.83 <.001 0.58 .02 0.49 NS Occipital cortex −0.36 NS −0.61 .02 −0.71 <0.01 0.74 <.01 0.39 NS 0.41 NS Caudate nuclei 0.02 NS −0.60 .02 −0.23 NS 0.35 NS 0.21 NS 0.10 NS Putamen 0.24 NS −0.58 .02 −0.78 <.001 0.72 <.01 0.81 <.001 0.72 <.01 Globi pallidi 0.05 NS −0.29 NS 0.55 .03 0.46 NS 0.51 NS 0.48 NS Thalami 0.12 NS −0.56 .03 −0.30 NS 0.30 NS 0.22 NS 0.09 NS Note:—Bold indicates statistically significant data.
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