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Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging

J.J. Pillai
American Journal of Neuroradiology June 2010, 31 (6) 990-996; DOI: https://doi.org/10.3174/ajnr.A1896
J.J. Pillai
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    Fig 1.

    BOLD activation maps (P < .001, 10-voxel clustering) for patient 1, who was scanned 2 weeks preoperatively (top row) and 5.5 (second row) and 15.5 (third row) months postoperatively with performance of an NV task. Both postoperative functional datasets are normalized to the initial preoperative anatomy with overlay of each postoperative BOLD activation map on the preoperative postgadolinium 3D MPRAGE anatomic image set, thus allowing evaluation of interval changes in topography of activation clusters in the same stereotactic space. Note the greater right middle frontal gyrus activation in the second scan compared with the preoperative scan, which is maintained in the third (ie, second postoperative) scan.

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    Fig 2.

    BOLD activation maps (P < .001, 10-voxel clustering) for patient 2, who underwent left frontotemporal anaplastic astrocytoma resection; scans were obtained 2 weeks preoperatively (top row) and 5.5 (second row) and 31 months (last row) postoperatively, with performance of the identical P task. No normalization of data was performed, but instead postoperative functional maps were overlaid on actual corresponding postoperative postgadolinium 3D MPRAGE anatomic images from the same scanning session as the respective BOLD acquisitions. Note the more extensive and robust right inferior and middle frontal gyri activation in the second postoperative scanning session compared with the preoperative and first postoperative sessions.

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American Journal of Neuroradiology: 31 (6)
American Journal of Neuroradiology
Vol. 31, Issue 6
1 Jun 2010
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J.J. Pillai
Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging
American Journal of Neuroradiology Jun 2010, 31 (6) 990-996; DOI: 10.3174/ajnr.A1896

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Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging
J.J. Pillai
American Journal of Neuroradiology Jun 2010, 31 (6) 990-996; DOI: 10.3174/ajnr.A1896
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  • Article
    • Abstract
    • Abbreviations
    • Brief Case Studies Demonstrating Postsurgical Plasticity
    • Significance of These Findings in the Context of the Literature on Postlesional Language Plasticity
    • Epilepsy-Related Language Plasticity
    • Effect of Age of Onset on Cortical Adaptation
    • Extensive Literature Describing Stroke-Related Language Plasticity
    • The Phenomenon of Postsurgical Plasticity
    • Conclusions
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
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