Article Figures & Data
Figures
- Fig 1.
Scatterplot of the global-cortical-to-pons FDG ratio versus patient age for CN (A) and aMCI (B) subjects. The lines indicate the estimated mean as a function of age by using a nonparametric Loess scatterplot smoother. The shaded regions represent approximate pointwise 95% confidence intervals.
- Fig 2.
Boxplots with individual data points for the global-cortical-to-pons FDG summary measure by age and diagnosis for study subjects from the Mayo community (ADPR and ADRC) samples (A) and an independent population-based validation sample from the Mayo Clinic Study of Aging (B). The global cortical FDG-uptake summary measure was formed by combining the left and right parietal lobe (including the posterior cingulate gyrus and precuneus) and temporal lobe ratio values for each subject.
- Fig 3.
Voxel-based analysis of the FDG-PET uptake-to-pons ratio in aMCI-young patients compared with age- and sex-matched CN-young subjects (P < .005 uncorrected).
- Fig 4.
Voxel-based analysis of the FDG-PET uptake-to-pons ratio in aMCI-old patients compared with age- and sex-matched CN-old subjects (P < .005 uncorrected).
- Fig 5.
Pattern of gray matter reduction in aMCI-young patients compared with age- and sex-matched CN-young subjects demonstrated in red and yellow (P < .005 uncorrected).
- Fig 6.
Pattern of gray matter reduction in aMCI-old patients compared with age- and sex-matched CN-old subjects demonstrated in red and yellow (P < .005 uncorrected).
Tables
Study Sample Validation Sample Age≤73 Age > 73 Age > 73 CN (n = 13) aMCI (n = 13) Pa CN (n = 12) aMCI (n = 12) Pa CN (n = 13) aMCI (n = 10) Pa Sex Female 7 (54) 6 (46) .69 6 (50) 6 (50) >.99 5 (38) 2 (20) .34 Male 6 (46) 7 (54) 6 (50) 6 (50) 8 (62) 8 (80) Age at PET scan Median (IQR) 68 (66–71) 70 (63–70) .90 80 (78–82) 78 (77–82) .66 77 (76–82) 82 (78–84) .22 Range 57–73 55–72 75–85 74–86 74–90 76–87 Education Median (IQR) 16 (12–17) 14 (12–17) .86 12 (12–14) 14.5 (12–18.5) .20 14 (13–16) 12 (12–16) .16 Range 10–20 12–20 8–20 8–20 12–19 11–19 MMSE score Median (IQR) 30 (29–30) 27 (26–28) .002 29 (27–29) 27 (27–28) .08 28 (26–28) 27 (26–27) .17 Range 27–30 25–30 26–30 24–29 24–30 21–28 CDR sum of boxes Median (IQR) 0 (0–0) 0.5 (0.5–1.5) <.001 0 (0–0) 1.0 (0.5–2.0) <.001 0 (0–0.5) 1.3 (1.0–1.9) <.001 Range 0–0 0.5–2.5 0–0 0.5–3.0 0–0.5 0–3.0 a Wilcoxon rank sum test.
Age≤73 years Age > 73 years Pa CN (n = 13) MCI (n = 13) CN (n = 12) MCI (n = 12) WMH volume, (cm3)a Median (IQR) 6 (4–8) 10 (6–25) 14 (8–18) 15 (12–25) .01 Range 1–14 4–45 6 to 25 4–65 Subcortical infarctions, no. (%) Present 1 (8) 1 (8) 2 (17) 2 (17) .74 Absent 12 (92) 12 (92) 10 (83) 10 (83) Cortical infarctions (<1-cm diameter) Present 0 1 (8) 0 2 (17) 0.31 Absent 13 (100) 12 (92) 12 (100) 10 (83) a Differences across all 4 groups were tested with the Kruskal-Wallis test. Differences in rates of infarctions across all 4 groups were tested with the Fisher exact test.
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