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Research ArticleSpine

T2 Relaxation Times Correlated with Stage of Lumbar Intervertebral Disk Degeneration and Patient Age

N.L. Marinelli, V.M. Haughton and P.A. Anderson
American Journal of Neuroradiology August 2010, 31 (7) 1278-1282; DOI: https://doi.org/10.3174/ajnr.A2080
N.L. Marinelli
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V.M. Haughton
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P.A. Anderson
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  • Fig 1.
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    Fig 1.

    Color image of a T2 relaxation time map. The color scale ranges from 25 to 146 ms. The image shows 5 lumbar disks. A grade II disk is illustrated at L1–2; grade III, at L3–4 and L4–5; grade IV, at L2–3; and grade V, at L5–S1. Areas with T2 relaxation times that are off the scale are black, for example, as shown by the CSF in the central spinal canal. The color scale shows relaxation times from 25 ms (red end of scale) to 146 ms (blue end of scale).

  • Fig 2.
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    Fig 2.

    Region-of-interest placement for the whole disk (A and D), nucleus pulposus region (B and E), and annulus fibrosus (C and F) for a Pfirrmann grade II disk (A–C) and a Pfirrmann grade IV disk (D–F).

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    Fig 3.

    T2-weighted images illustrating 4 Pfirrmann disk grades. Midsagittal images show a grade II disk (A) with high signal intensity in the central region and lower signal intensity in the peripheral region, clearly distinguishing the nucleus pulposus region from the annulus fibrosus; a grade III disk (B) with lower signal intensity in the central region and less clear distinction between the nucleus pulposus region and annulus; a grade IV disk (C) with homogeneously low signal intensity and with no distinction of the nucleus pulposus region and annulus; and a grade V disk (D), which is collapsed.

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    Fig 4.

    T2-weighted image of a disk initially interpreted by 1 reader as Pfirrmann grade III and by the other reader as grade IV. By consensus, it was classified as grade IV.

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    Fig 5.

    Mean T2 relaxation times versus Pfirrmann grade for whole disks (A) and the nucleus pulposus region (B). The means (±SDs) for all disks of each grade are illustrated. The vertical bars represent the SD from the mean.

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    Fig 6.

    Mean T2 relaxation times for the nucleus pulposus region of Pfirrmann grade II disks for each decade of life. Mean T2 relaxation times are calculated as the averages for those in their 20s, 30s, 40s, 50s, and 60s. The vertical bars represent the SD from the mean.

Tables

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  • Demographic, clinical, and L1–2 through L5–S1 imaging data for the 20 patients

    Patient No.Age (yr)SexClinical Indication for ImagingImaging Findings
    154MLow back pain, leg painL4–5 stenosis
    269FDegenerative spondylolisthesis L4/L5
    364FSevere leg painL5–S1 herniated disk
    445FLow back painL3–4 disk collapse
    551FLow back painL5–S1 spondylolisthesis and disk bulge
    634MBack painL5–S1 herniated disk, sacral metastasis from male breast cancer
    760MLow back pain3-Level disk degeneration
    821FSciaticaNormal MRI findings
    930FLow back pain2-Level disk degeneration
    1036MLow back painPostop L4–5 laminectomy, small L5–S1 protrusion
    1144FLow back painFacet joint disease 2 levels
    1235MLow back pain, saddle paresthesiasL3–4 herniated disk, L4–5 microdiskectomy, L5–S1 high-intensity zone
    1349FRight buttock painPostop L3–4 and L4–5 laminectomy
    1427FLow back painL5–S1 disk degeneration
    1569MLow back painHematoma at L2, bulging disks at L2–3 and L3–4
    1665FLow back painPostop L4–5 laminectomy, bulging annulus, 5 levels
    17a36FLow back painNormal MRI findings
    1840FLow back painBreast metastasis S1
    1965MLow back painFacet degeneration, stenosis, and spondylolisthesis at L4–5, disk degeneration at L5–S1
    2062MParesthesiasMildly degenerated disks L3–4, L4–5
    • a Patient No. 17 was excluded due to motion artifacts.

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American Journal of Neuroradiology: 31 (7)
American Journal of Neuroradiology
Vol. 31, Issue 7
1 Aug 2010
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Cite this article
N.L. Marinelli, V.M. Haughton, P.A. Anderson
T2 Relaxation Times Correlated with Stage of Lumbar Intervertebral Disk Degeneration and Patient Age
American Journal of Neuroradiology Aug 2010, 31 (7) 1278-1282; DOI: 10.3174/ajnr.A2080

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T2 Relaxation Times Correlated with Stage of Lumbar Intervertebral Disk Degeneration and Patient Age
N.L. Marinelli, V.M. Haughton, P.A. Anderson
American Journal of Neuroradiology Aug 2010, 31 (7) 1278-1282; DOI: 10.3174/ajnr.A2080
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