Article Figures & Data
Figures
- Fig 1.
Correlation of brain tissue volume (A) and brain tissue/ICV ratio (B) with cognitive status. The black vertical crossbars indicate the timeline when VP shunt was placed.
- Fig 2.
Correlation of LV volume (A) and LV/ICV ratio (B) with cognitive status. The vertical crossbars indicate the timeline when VP shunt was placed.
- Fig 3.
Examples of the automated segmentation of brain and semi-automated segmentation of lateral ventricles. A, Original axial T1 image; B, aligned and registered T1 image; C, segmented image, where green voxels represent gray matter, pink voxels represent white matter, and dark blue voxels represent CSF; D, registered T1 axial image; E, 2D view of the segmented lateral ventricles in red; F, 3D view of the lateral ventricles (enlarged).
Tables
Volumetric analysis of brain MR Imaging in MPS II Patients
Variables All Patients MR Imaging Studies (N = 33), Mean (SD) Patients with Cognitive Impairment MR Imaging Studies (N = 22), Mean (SD) Patients with Normal Cognition MR Imaging Studies (N = 11), Mean (SD) P Valuea Age (years) 9.0 (5.0) 9.9 (6.2) 7.5 (2.37) .296 ICV (mL) 1443 (189) 1464 (201) 1407 (176) .96 Brain tissue (mL) 1242 (173) 1234 (195) 1254 (143) .25 LV (mL) 54 (48) 73 (52) 21 (13) .046b Brain tissue/ICV 0.86 (0.012) 0.84 (0.03) 0.89 (0.01) <.001b LV/ICV 0.04 (0.015) 0.05 (0.03) 0.01 (0.01) .029b a P values were comparisons between patients with cognitive impairment and those with normal cognition.
b P values reached statistical significance.
